Adenine-based small molecule fluorescent probe for imaging mitochondrial nucleic acid

Application of Lab-on-Chip for Detection of Microbial Nucleic Acid in Food and Environment

“…For example, 4′, 6-diamidino-2-phenylindole (DAPI) is a DNA-specific probe that forms fluorescent complexes by attaching to A-T-rich DNA sequences ( Kapuscinski, 1995 ). Wei et al (2020) designed and synthesized a small-molecule fluorescent probe based on adenine-coumarin derivative. The probe showed significant fluorescence enhancement to nucleic acid at 495 nm (DNA) and 487 nm (RNA), and the fluorescence intensity showed a good linear relationship with the concentration of nucleic acid.…”

Unraveling the photophysical characteristics and biological applications of vinyl sulfones as viscosity sensors

“…In this regard, we and others developed small molecule-based uorescent probes for biological applications such as cellular imaging and microorganism targeting. [12][13][14] As a part of our continuing endeavour to develop uorescent probes, we hypothesized that modication of the small molecule vinyl sulfones would affect its photophysical characteristics. Due to the lack of conclusive study on the photophysical and imaging features of vinyl sulfone, we present here the chemical reduction of non-uorescent probes, vinyl sulfone-NO 2 (3), to uorescent probes, vinyl sulfone-NH 2 (4).…”

“…In this regard, we and others developed small molecule-based fluorescent probes for biological applications such as cellular imaging and microorganism targeting. 12–14…”

Magnetically driven helical hydrogel micromotor for tumor DNA detection

“…DNA detection, includes spectroscopic analysis, electrochemical analysis, and biological analysis [ 10 , 11 , 12 , 13 , 14 ]. Among them, the fluorescent probe is one of the most promising and efficient techniques for detecting DNA, with characteristics of simple operation, rapid detection, and high sensitivity [15] . The monomeric cyanine dye, SYBR Green I (SG), has been applied for the fluorescent detection of nucleic acids [16] .…”