Fluorescence-based techniques are essential for the analysis of nucleic acids. Two readily obtainable small cationic dyes with increased fluorescence following non-covalent DNA binding showed selectivity for Gram-negative bacteria and cancer cells.
Vinyl sulfone-NH2 (4d) exhibited an 85-fold increase in fluorescence in a high-viscosity solvent, and the sensor could identify viscosity changes in the microenvironment of cancer cells specifically.
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