Colorectal cancer (CRC) screening reduces mortality from this second leading cause of cancer deaths in the United States. 1 However, only 69% of eligible adults in the United States are up to date with CRC screening, with lower rates of screening among racial/ethnic minority groups and individuals with lower socioeconomic status. 1 Therefore, evidence-based interventions to improve CRC screening adherence are needed, especially interventions that address screening disparities.In their systematic review and meta-analysis of randomized clinical trials (RCTs), Facciorusso et al, 2 evaluated the benefit of financial incentives for CRC screening uptake. This study included RCTs of adults who were eligible for CRC screening and received various financial incentives (fixedamount or lottery-based incentives that were unconditional or conditional on screening completion) or no financial incentives (screening reminders or mailed outreach alone). The primary outcome of interest was CRC screening completion using recommended tests within 12 months of receiving the intervention. The authors analyzed 8 RCTs, which represented 110 644 patients (53 444 were offered financial incentives, and 57 200 were not offered financial incentives). These US-based studies, which were published between 2014 and 2020, included screening with fecal occult blood test or fecal immunochemical test (FIT; 4 RCTs), colonoscopy (3 RCTs), or other approved screening tests (1 RCT