Adding low ankle brachial index to classical risk factors improves the prediction of major cardiovascular events. The REGICOR study

Velescu, Alina; Clarà, Albert Benet i; Peñafiel, Judith; Ramos, Rafael; Martí, Ruth; Grau, María; Dégano, Irene R.; Marrugat, Jaume; Elosúa, Roberto

doi:10.1016/j.atherosclerosis.2015.05.017

Cited by 34 publications

(21 citation statements)

References 40 publications

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“…HR of having a coronary event using pathological ABI and the risk table category as mutually adjusted was 2.55 in case of Framingham and 2.66 in case of REGICOR. It was similar to the previous results of national [ 12 , 18 , 34 ] and international [ 15 , 19 , 20 , 22 ] studies.…”

Section: Discussionsupporting

confidence: 92%

“…While some recommend the addition of the ABI or consider this index to be a modifier of risk, others are not so favorable or do not make any recommendation in this respect [ 35 – 38 ]. Several studies have also analyzed the reclassification capacity of coronary events with the addition of the ABI to risk scales [ 7 , 16 – 18 , 20 , 22 , 23 ]. Some of these studies did not observe any improvement in the reclassification of global risk.…”

Section: Discussionmentioning

confidence: 99%

“…Some of these studies did not observe any improvement in the reclassification of global risk. In the ARIC study [ 16 ] the NRI of men and women together was 0.8%, being 0.6% in the Rotterdam study [ 7 ] and 1% in the Velescu et al study [ 18 ] with the use of this statistic. A modest improvement was described with a NRI of 3.3% in the Rodondi et al study [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort

et al. 2018

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BackgroundThe different cardiovascular risk prediction scales currently available are not sufficiently sensitive.AimThe aim of the present study was to analyze the contribution of the ankle-brachial index (ABI) added to the Framingham and REGICOR risk scales for the reclassification of cardiovascular risk after a 9-year follow up of a Mediterranean population with low cardiovascular risk.Design and settingA population-based prospective cohort study was performed in the province of Barcelona, Spain.MethodA total of 3,786 subjects >49 years were recruited from 2006–2008. Baseline ABI was performed and cardiovascular risk was calculated with the Framingham and REGICOR scales. The participants were followed until November 2016 by telephone and review of the clinical history every 6 months to confirm the possible appearance of cardiovascular events.Results2,716 individuals participated in the study. There were 126 incidental cases of first coronary events (5%) during follow up. The incidence of coronary events in patients with ABI <0.9 was 4-fold greater than that of subjects with a normal ABI (17.2/1,000 persons-year versus 4.8/1,000 persons-year). Improvement in the predictive capacity of REGICOR scale was observed on including ABI in the model, obtaining a net reclassification improvement of 7% (95% confidence interval 0%-13%) for REGICOR+ ABI. Framingham + ABI obtained a NRI of 4% (-2%-11%).ConclusionThe results of the present study support the addition of the ABI as a tool to help in the reclassification of cardiovascular risk and to confirm the greater incidence of coronary events in patients with ABI < 0.9.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort

et al. 2018

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“…The recruitment details have previously been described elsewhere. 3,18,19 In summary, individuals living in the city of Girona and three surrounding villages were randomly selected from the census and invited to participate. At recruitment, participants were aged 35e79 years, had lived in the referral area for at least 6 months, were free of terminal disease, and were not institutionalised.…”

Section: Study Design and Populationmentioning

confidence: 99%

Abnormally High Ankle–Brachial Index is Associated with All-cause and Cardiovascular Mortality: The REGICOR Study

Velescu

Clarà

Martí

et al. 2017

European Journal of Vascular and Endovascular Surgery

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“…In addition, high ABI values (>1.40 or incompressible) were correlated with greater left ventricular mass measured by cardiac magnetic resonance [63]. Furthermore, adding ABI less than or equal to 0.9 to traditional risk factors can improve the prediction value of major cardiovascular events [64]. And another meta-analysis found that ABI was able to improve the accuracy of cardiovascular risk prediction better than the Framingham risk score [65].…”

Section: Measurement Of Limb Artery-ankle Brachial Index (Abi)mentioning

confidence: 99%

Early Detection System of Vascular Disease and Its Application Prospect

Liu

Wang

2016

BioMed Research International

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Markers of imaging, structure, and function reflecting vascular damage, integrating a long time accumulation effect of traditional and unrecognized cardiovascular risk factors, can be regarded as surrogate endpoints of target organ damage before the occurrence of clinical events. Prevention of cardiovascular disease requires risk stratification and treatment of traditional risk factors, such as smoking, hypertension, hyperlipidemia, and diabetes. However, traditional risk stratification is not sufficient to provide accurate assessment of future cardiovascular events. Therefore, vascular injury related parameters obtained by ultrasound or other noninvasive devices, as a surrogate parameter of subclinical cardiovascular disease, can improve cardiovascular risk assessment and optimize the preventive treatment strategy. Thus, we will summarize the research progress and clinical application of early assessment technology of vascular diseases in the present review.

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Adding low ankle brachial index to classical risk factors improves the prediction of major cardiovascular events. The REGICOR study

Cited by 34 publications

References 40 publications

Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort

Contribution of the ankle-brachial index to improve the prediction of coronary risk: The ARTPER cohort

Abnormally High Ankle–Brachial Index is Associated with All-cause and Cardiovascular Mortality: The REGICOR Study

Early Detection System of Vascular Disease and Its Application Prospect

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