Early Detection System of Vascular Disease and Its Application Prospect

Liu, Huan; Wang, Hongyu

doi:10.1155/2016/1723485

Cited by 16 publications

(8 citation statements)

References 98 publications

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“…Furthermore, ankle-brachial index (ABI), carotid intimal medial thickness (CIMT), cardio-ankle vascular index (CAVI), and pulse wave velocity (PWV), which reflex vascular endothelial function have been used as testing techniques to identify subclinical vascular atherosclerotic changes [23].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular risks in Asian HIV-infected patients receiving boosted-protease inhibitor-based antiretroviral treatment

Ounjaijean

Kulprachakarn

Aurpibul

et al. 2021

J Infect Dev Ctries

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Introduction: Increased risk of cardiovascular disease in HIV-infected patients was tought to be the cause of multiple mechanistic factors, which changing the HIV care landscape. Antiretroviral therapy (ART), especially protease inhibitors (PI), is one of common HIV treatments that may have some association with this. The mechanism of PI in comparison to other regimens, however, are not clearly understood. Methodology: Age-and gender-match HIV-infected patients treated with either boosted-PI-based regimen (boosted-PI group, N=30) or NNRTI-based ART (non-PI group, N = 30) were recruited for this cross-sectional study. Parameters determined cardiovascular risks, inflammation, endothelial function, and bone metabolic function were evaluated. Results: Compared with non-PI, patients in the boosted-PI group had more evidence of dyslipidemia. No statistical difference in the prevalence of subclinical atherosclerosis was found between the two groups. Circulating levels of inflammatory markers, C-reactive protein (CRP) (5.4±9.1 vs. 14.9 ± 19.4 mg/L, p = 0.019) and lectin-liked oxidized lipoprotein receptor-1 (LOX-1) (387 ± 299 vs. 554 ± 324 pg/mL, p = 0.042) were lower in boosted-PI group. Contrastingly, Vascular adhesion molecules-1 (VCAM-1) (160.2 ± 80.0 vs. 147.8 ± 66.3 ng/mL, p = 0.010), and osteoprotegerin (OPG) (153.7 ± 57.1 vs. 126.4 ± 35.8, p = 0.031) were higher. After adjustment in the multivariate analysis, PI treatment is the only independent parameter associated with the changes of CRP, LOX-1, VCAM-1, and OPG. Subgroup analysis showed that ARV treatment effects differed among participant having dyslipidemia. Conclusions: The major mechanism in which PI-mediated was triggering atherogenesis could be through alteration of lipid metabolism and endothelial function, but no evidence of accelerated pro-inflammatory response was attested.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular risks in Asian HIV-infected patients receiving boosted-protease inhibitor-based antiretroviral treatment

Ounjaijean

Kulprachakarn

Aurpibul

et al. 2021

J Infect Dev Ctries

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“…Flow-mediated vasodilation is widely accepted as a non-invasive method for vascular endothelial function evaluation and an indicator for early coronary lesions [14]. NO and ET-1 are also considered biomarkers for vascular endothelial function.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

Li¹,

Zhang

Liang

et al. 2018

Cardiol J.

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Background: To improve therapy for slow coronary flow (SCF), the effects of hyperbaric oxygen (HBO) therapy on vascular endothelial function in divided into two groups according to the following treatment: HBO group (n = 48) and the control group (n = 50). Patients in the control group were administrated with conventional treatment, while those in the HBO group were administrated HBO therapy for 4 weeks in addition to conventional treatment. To evaluate the effects of HBO on vascular endothelial functions, plasma levels of nitric oxide (NO), calcitonin gene-related peptide (CGRP), endothelin-1 (ET-1), high sensitivity C-reactive protein (hsCRP) as well as endothelial-dependent flowmediated vasodilation (FMD) of the brachial artery were measured in both groups before and after their respective treatments.Results: There were no significant differences in plasma levels of NO, CGRP, hsCRP (Cardiol J 2018; 25, 1: 106-112)

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“…However, whether the compliance obtained from the radial artery can reflect the compliance of the systemic blood vessels needs to be further confirmed. Similarly, the limited research evidence on C1 and C2 also limits the wide clinical application of these noninvasive vascular parameters [ 49 ].…”

Section: Evaluation Parameters Of Endothelial Functionmentioning

confidence: 99%

Clinical Evaluation Tool for Vascular Health–Endothelial Function and Cardiovascular Disease Management

Wen

Liu

Wang

2022

Cells

Self Cite

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There are 330 million people suffering from cardiovascular diseases (CVD) in China, and two out of every five deaths were due to CVD. CVD has become the main disease burden in China. Vascular health management can detect subclinical vascular diseases such as endothelial dysfunction. Through controlling risk factors, vascular function, such as endothelial function, can be improved and cardiovascular events can be prevented from the upstream. Peking University Shougang hospital is the first practitioner of life-long vascular health management since 2010 in China. The established Beijing Vascular Health Stratification (BVHS) focuses on the comprehensive evaluation of vascular health function and structure and explores the application of information technology and artificial intelligence in vascular health management. The life-long vascular health management and tertiary hospital–primary hospital–family service model guided by BVHS can better realize the prophylaxis of CVD. The prevention and control strategy of CVD based on information technology and vascular health, especially endothelial function management, can help to implement the “healthy China 2030” plan. In this review, we focus on advances in the clinical assessment of vascular endothelial function, including the evaluation of endothelial function, the evaluation of arteriosclerosis, new potential biological markers to provide new possible therapeutic targets, and BVHS, a comprehensive vascular aging assessment system. Strengthening the assessment of cardiovascular health and endothelial function is of great significance for the occurrence of cardiovascular diseases in risk groups and the occurrence of adverse events in patients with cardiovascular diseases.

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Early Detection System of Vascular Disease and Its Application Prospect

Cited by 16 publications

References 98 publications

Cardiovascular risks in Asian HIV-infected patients receiving boosted-protease inhibitor-based antiretroviral treatment

Cardiovascular risks in Asian HIV-infected patients receiving boosted-protease inhibitor-based antiretroviral treatment

Effects of hyperbaric oxygen on vascular endothelial function in patients with slow coronary flow

Clinical Evaluation Tool for Vascular Health–Endothelial Function and Cardiovascular Disease Management

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