Adaptive transfer of B10 cells: A novel therapy for chronic rejection after solid organ transplantation

Bao, Yongzhan; Xiu, Dian Rong

doi:10.1016/j.mehy.2013.03.037

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…Some studies have shown that B10 cells can effectively alleviate the severity of EAE in mice . B10 cell‐mediated therapy has also been studied in the field of transplantation . In allogeneic islet cell transplantation in mice, B10 cells express abundant MHC and costimulatory molecules and secrete various cytokines such as IL‐10 and TGF‐β .…”

Section: Regulatory Functions Of B Cells In Transplantationmentioning

confidence: 99%

“…B10 cell‐mediated therapy has also been studied in the field of transplantation . In allogeneic islet cell transplantation in mice, B10 cells express abundant MHC and costimulatory molecules and secrete various cytokines such as IL‐10 and TGF‐β . Besides, naïve B10 cells in recipients are activated by MHC molecules derived from donors.…”

Section: Regulatory Functions Of B Cells In Transplantationmentioning

confidence: 99%

“…Besides, naïve B10 cells in recipients are activated by MHC molecules derived from donors. B10 cells can suppress T cell‐mediated rejection and exert immunosuppression in the MHC‐mismatched area, thereby prolonging MHC‐mismatched cell survival and Treg expansion during the allograft immune response . Although investigations of the immunosuppressive effect of B10 cells have mostly concentrated on animal experiments, their immunosuppression has evoked the interest of clinicians to explore the unique therapeutic advantages of IL‐10‐mediated treatment in human organ transplant …”

Section: Regulatory Functions Of B Cells In Transplantationmentioning

confidence: 99%

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Regulatory B cells and advances in transplantation

Luo

Wang

et al. 2018

Journal of Leukocyte Biology

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The effects of B cell subsets with regulatory activity on the immune response to an allograft have evoked increasing interest. Here, we summarize the function and signaling of regulatory B cells (Bregs) and their potential effects on transplantation. These cells are able to suppress the immune system directly via ligand–receptor interactions and indirectly by secretion of immunosuppressive cytokines, particularly IL‐10. In experimental animal models, the extensively studied IL‐10‐producing B cells have shown unique therapeutic advantages in the transplant field. In addition, adoptive transfer of B cell subsets with regulatory activity may reveal a new approach to prolonging allograft survival. Recent clinical observations on currently available therapies targeting B cells have revealed that Bregs play an important role in immune tolerance and that these cells are expected to become a new target of immunotherapy for transplant‐related diseases.

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Section: Regulatory Functions Of B Cells In Transplantationmentioning

confidence: 99%

Section: Regulatory Functions Of B Cells In Transplantationmentioning

confidence: 99%

Section: Regulatory Functions Of B Cells In Transplantationmentioning

confidence: 99%

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Regulatory B cells and advances in transplantation

Luo

Wang

et al. 2018

Journal of Leukocyte Biology

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“…It is possible that regulatory fine tuning by B-cells and IL-21 production by T-cells might be a key factor in maintaining immune tolerance (78). Most investigations of B10 cells have concentrated on autoimmune diseases (79), but a few have assessed their role in transplantation (80). A mouse islet T-cell transplantation study has demonstrated that B10 cells control immune responses (81).…”

Section: Regulatory B (B10) Cellsmentioning

confidence: 99%

“…In addition to its actions in B-cell apoptosis and differentiation it also drives regulatory B10 responses. These cells have been shown to suppress T-cell-mediated rejection induced by mismatched MHC molecules and prolong allogeneic islet T-cell survival, suggesting a potential regulatory role for B10 cells in organ transplantation (80, 81). Since IL-21 can promote regulatory B10 cell proliferation, harnessing the anti-inflammatory properties of B10 cells by anti-IL-21 agents could potentially stimulate antibody-mediated rejection and promote a less favorable tolerogeneic environment by modulating the plasma cell/Breg (B10) balance (68) (Figure 7).…”

Section: Il-21 As a Possible Player In Alloreactivity After Transplanmentioning

confidence: 99%

The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation

Besouw

Shi

et al. 2016

Front. Immunol.

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Antibody-mediated rejection has emerged as one of the major issues limiting the success of organ transplantation. It exerts a highly negative impact on graft function and outcome, and effective treatment is lacking. The triggers for antibody development, and the mechanisms leading to graft dysfunction and failure, are incompletely understood. The production of antibodies is dependent on instructions from various immunocytes including CD4 T-helper cells that secrete interleukin (IL)-21 and interact with antigen-specific B-cells via costimulatory molecules. In this article, we discuss the role of IL-21 in the activation and differentiation of B-cells and consider the mechanisms of IL-21 and B-cell interaction. An improved understanding of the biological mechanisms involved in antibody-mediated complications after organ transplantation could lead to the development of novel therapeutic strategies, which control humoral alloreactivity, potentially preventing and treating graft-threatening antibody-mediated rejection.

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