B cell modulation strategies in the improvement of transplantation outcomes

Afzali, Shima; Salehi, Saeedeh; Shahi, Abbas; Amirzargar, Aliakbar

doi:10.1016/j.molimm.2020.06.028

Cited by 5 publications

(2 citation statements)

References 151 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD20 is a target of several therapeutic monoclonal antibodies used for the treatment of human (Atallah-Yunes et al, 2020;Cortelazzo et al, 2020;Hou et al, 2020;Lue and O'Connor, 2020) and canine (Jain et al, 2016;Mizuno et al, 2020) B cell lymphomas. More interestingly, anti-CD20 therapeutic antibodies are currently applied to the control of human chronic inflammatory disorders mediated by B cells (Afzali et al, 2020;Florou et al, 2020;Terrier et al, 2020). Thus, CD20 may represent a target molecule for the therapy of recurrent and severe cases of FLPR and other chronic lymphoplasmacytic disorders of cats.…”

Section: Discussionmentioning

confidence: 99%

Feline lymphoplasmacytic rhinitis (FLPCR): Severity of inflammation correlates with reduced mucosal IgA expression

Roccabianca

Turchetto

Ferrari

et al. 2021

Veterinary Immunology and Immunopathology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Feline lymphoplasmacytic rhinitis (FLPCR): Severity of inflammation correlates with reduced mucosal IgA expression

Roccabianca

Turchetto

Ferrari

et al. 2021

Veterinary Immunology and Immunopathology

View full text Add to dashboard Cite

“…B lymphocytes are key players in different pathological situations. With their ability to produce antibodies ( 1 ), pro-inflammatory cytokines ( 2 ) as well as to express MHC and costimulatory molecules ( 3 ), they are able to drive and maintain immune response ( 4 ). However, over the last decade, there are increasing evidences of the existence of B cells with suppressive properties, also known as regulatory B cells (Bregs) ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

Sailliet,

Mai,

Dupuy

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

IntroductionHuman Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. Moreover, these cells may be easily induced in vitro making them interesting for cell therapy.MethodsWe characterized this population of in vitro induced GZMB+Bregs using single cell transcriptomics. To investigate their regulatory properties, Bregs or total B cells were also co-cultured with T cells and scRNAseq was used to identify receptor ligand interactions and to reveal gene expression changes in the T cells.ResultsWe find that Bregs exhibit a unique set of 149 genes differentially expressed and which are implicated in proliferation, apoptosis, metabolism, and altered antigen presentation capacity consistent with their differentiated B cells profile. Notably, Bregs induced a strong inhibition of T cell genes associated to proliferation, activation, inflammation and apoptosis compared to total B cells. We identified and validated 5 receptor/ligand interactions between Bregs and T cells. Functional analysis using specific inhibitors was used to test their suppressive properties and we identified Lymphotoxin alpha (LTA) as a new and potent Breg ligand implicated in Breg suppressive properties.DiscussionWe report for the first time for a role of LTA in GZMB+Bregs as an enhancer of GZMB expression, and involved in the suppressive properties of GZMB+Bregs in human. The exact mechanism of LTA/GZMB function in this specific subset of Bregs remains to be determined.

show abstract

Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes

Chaudhary

Nguyen

Yook

et al. 2023

J. Pharm. Investig.

View full text Add to dashboard Cite

B cell modulation strategies in the improvement of transplantation outcomes

Cited by 5 publications

References 151 publications

Feline lymphoplasmacytic rhinitis (FLPCR): Severity of inflammation correlates with reduced mucosal IgA expression

Feline lymphoplasmacytic rhinitis (FLPCR): Severity of inflammation correlates with reduced mucosal IgA expression

Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

Advances in alginate encapsulation of pancreatic islets for immunoprotection in type 1 diabetes

Contact Info

Product

Resources

About