Adaptive capacity of the cardiovascular system in children with rheumatic diseases and comorbid conditions

Shevchenko, N.; Bogmat, L.F.; Holovko, Tetiana; Demianenko, M. V.

doi:10.14739/2310-1237.2019.1.166395

Cited by 3 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Як відомо, ураження серцево-судинної системи у дорослих із РЗ -це перш за все розвиток хронічної серцевої недостатності та атеросклеротичних уражень коронарних судин із розвитком інфаркту міокарда, хронічної ішемічної хвороби серця або ішемічних проявів з боку периферичних судин [4,5]. У зв'язку з цим розроблено рекомендації з профілактики кардіоваскулярного ризику у хворих із ревматоїдним артритом [18].…”

Section: результати та обговоренняunclassified

“…Крім того, у дітей із РЗ (СЧВ та ЮІА) поступово, при збільшенні тривалості процесу, знижуються показники ударного та хвилинного об'ємів крові, збільшуються розміри лівого передсердя (2,27 ± 0,09 см та 2,02 ± 0,09 см; р ≤ 0,05) та кінцево-діастолічний розмір лівого шлуночка (3,86 ± 0,14 см та 3,74 ± 0,13 см; р ≤ 0,05), що свідчить про морфофункціональну перебудову серця та формування дисфункції міокарда, як систолічної, так і діастолічної, що значно впливає на їх адаптивні можливості [18].…”

Section: результати та обговоренняunclassified

See 1 more Smart Citation

Comorbidity in children with rheumatic diseases: literature review and 10-year experience of own research

Bogmat

Shevchenko

Holovko

et al. 2023

View full text Add to dashboard Cite

Background. A decrease in the age of onset of rheumatic diseases in children, an increase in the total duration of the disease, the development of persistent functional and organic disorders of organs and systems determine the need to study comorbid conditions already in childhood in order to optimize their diagnosis and comprehensive therapy. The purpose was to study the frequency and main patterns for the formation and further progression of comorbidities in children with rheumatic diseases (juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE)). Materials and methods. An analytical review of the literature on the prevalence and diagnosis of comorbid lesions in adult patients with rheumatic diseases and in children was carried out; 250 children aged 3–18 years with JIA and 67 children with SLE with a juvenile onset were dynamically monitored for the presence of comorbid conditions of the cardiovascular system, kidneys, lungs, eyes, bone tissue, blood lipid disorders. Results. The frequency and nature of comorbidity in children with JIA and SLE have been determined. Preservation of the process activity is the main factor in the progression of comorbid pathology and the formation of irreversible damage to organs and systems with the development of their failure and violations of the quality of life of patients. Conclusions. Based on the presented materials, it is possible to develop programs to prevent the formation and progression of irreversible damage to systems and organs that occur under comorbid conditions in children with rheumatic diseases and to effectively socialize these children.

show abstract

Section: результати та обговоренняunclassified

Comorbidity in children with rheumatic diseases: literature review and 10-year experience of own research

Bogmat

Shevchenko

Holovko

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Taking into account that symptoms of cardiovascular pathology can be hidden due to adaptive mechanisms, heart diseases can develop asymptomatically (Lee, Chandel, & Simon, 2020;Nakamura & Sadoshima, 2018;Shevchenko, Bohmat, Holovko, & Demianenko, 2019). The pathways leading from biomechanical overload to cardiac remodeling are of primary clinical importance, but this process remains not fully defined (Weinberg et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of serum soluble ST2 in professional athletes (Valor pronóstico de ST2 soluble en suero en deportistas profesionales)

Baurzhan¹,

Berkinbayev²,

Abzaliyev³

et al. 2021

Retos

View full text Add to dashboard Cite

Background: The predictive value of serum soluble ST2 (sST2) biomarker for diagnostics of cardiovascular pathologies is still poorly understood as well as the role of psychological stress on the risk of heart disease. Aim: This study aimed at determining the diagnostic significance of the sST2 level in athletes involved in speed-strength sports. In addition, stress as a risk factor for the development of cardiovascular pathology was assessed and analysed as well. Methods: A prospective study on Greco-Roman wrestlers was carried out at the Centre for Sports Medicine and Rehabilitation (Almaty, Republic of Kazakhstan). All participants (n = 30) were males aged 20 to 34 years. The control group consisted of volunteers (VO) (n = 30). Anthropometric and hemodynamic parameters of athletes were studied along with electrocardiography (ECG) and ECG tests. The sST2 level was determined before (BT) and immediately after (AT) training. The stress level was determined using The Perceived Stress Scale-10 (PSS-10). Results: The average age of the athletes was 26.57 ± 3.6 years. The total training experience was 14.57 ± 4.02 years. According to the ECG data, minor deviations from the norm (13.3%) and an abnormal ECG (33.3%) were identified. Echo-CG data showed "moderate" and "pronounced changes" in 23.3% and 53.3% of cases, respectively. The sST2 level of VO (337.1 ± 61.8 pg / mL) was lower than that of BT (548.1 ± 32.6 pg / mL) (p ≤ 0.001). The sST2 level of AT, it was significantly higher (830.01 ± 71.6 pg / mL) than BT (p ≤ 0.001). The average and high level of stress among athletes was in 43.3% and 56.7% of cases, respectively. Stress increased the likelihood of developing distinctly abnormal ECG (OR = 1.06, 95% CI 1.01–1.08; p = 0.02). The stress level showed a positive correlation with the sST2 level (r = 0.752, p = 0.01). The sST2 concentration and categorical echocardiography data demonstrated a dependent positive correlation (r = 0.6, p = 0.01). Conclusions: Athletes' sST2 levels exceeded thresholds both before and after training. Moreover, the relationship between an increase in sST2 levels and abnormal ECG abnormalities and a high level of stress in athletes was determined. sST2 concentration was associated with cardio-pulmonary stress triggered by the cumulative exercise dose as well as with lifelong psychological stress. Our findings indicate that the elevated sST2 concentrations in athletes could be used as the predictive value. However, clinical relevance and results validity require further intensive studies. Resumen. Antecedentes: El valor predictivo del biomarcador ST2 soluble en suero (sST2) en la enfermedad cardiovascular aún no se conoce bien, así como el papel del estrés psicológico en el riesgo de enfermedad cardiovascular. Objetivos: Este estudio tuvo como objetivo determinar la importancia diagnóstica del nivel de sST2 en atletas involucrados en deportes de velocidad-fuerza. Además, también se evaluó y analizó el estrés como factor de riesgo para el desarrollo de patología cardiovascular. Métodos: Se llevó a cabo un estudio prospectivo sobre luchadores grecorromanos en el Centro de Medicina y Rehabilitación del Deporte (Almaty, República de Kazajstán). Todos los participantes (n = 30) eran hombres de entre 20 y 34 años. El grupo de control estaba formado por voluntarios (VO) (n = 30). Se estudiaron los parámetros antropométricos y hemodinámicos de los atletas junto con las pruebas de electrocardiografía (ECG). El nivel de sST2 se determinó antes (BT) e inmediatamente después (AT) del entrenamiento. El nivel de estrés se determinó utilizando la Escala de Estrés Percibido-10 (PSS-10). Resultados: La edad promedio de los deportistas fue de 26,57 ± 3,6 años. La experiencia de formación total fue de 14,57 ± 4,02 años. Según los datos del ECG, se identificaron desviaciones menores de la norma (13,3%) y un ECG anormal (33,3%). Los datos de Echo-CG mostraron cambios "moderados" y "pronunciados" en el 23,3% y el 53,3% de los casos, respectivamente. El nivel de sST2 del grupo VO (337,1 ± 61,8 pg / mL) fue menor que el de BT (548,1 ± 32,6 pg / mL) (p ≤ 0,001),). El nivel de sST2 en AT fue significativamente mayor (830.01 ± 71.6 pg / mL) que en BT (p ≤ 0.001). El nivel medio y alto de estrés entre los deportistas fue del 43,3% y el 56,7% de los casos, respectivamente. El estrés aumentó la probabilidad de desarrollar un ECG claramente anormal (OR = 1,06; IC del 95%: 1,01-1,08; p = 0,02). El nivel de estrés mostró una correlación positiva con el nivel de sST2 (r = 0,752, p = 0,01). La concentración de sST2 y los datos de la ecocardiografía categórica demostraron una correlación positiva dependiente (r = 0,6, p = 0,01). Conclusión: Los niveles de sST2 de los atletas excedieron los umbrales tanto antes como después del entrenamiento. Además, se determinó la relación entre un aumento en los niveles de sST2 y anomalías anormales del ECG y un alto nivel de estrés en los atletas. La concentración de sST2 se asoció con el estrés cardiopulmonar desencadenado por la dosis acumulativa de ejercicio, así como con el estrés psicológico de por vida. Nuestros hallazgos indican que las concentraciones elevadas de sST2 en los atletas pueden usarse como valor predictivo. Sin embargo, se requieren más estudios.

show abstract

“…Вихідні вимірювання проводилися після трихвилинного відпочинку пацієнта у положенні сидячи. Після проби підрахунок ЧСС та вимірювання АТ проводилися на першій відновлювальній хвилині [5,10,11].…”

unclassified

Adaptive capabilities of the cardiovascular system, taking into account regulation systems, in adolescents with juvenile idiopathic arthritis

Holovko

Bogmat

Shevchenko

et al. 2023

View full text Add to dashboard Cite

Background. Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood (1 : 1,000 children), which involves many organs and systems, primarily cardiovascular, with the gradual development of chronic heart failure. As you know, when the functional capacity of the heart decreases, a cascade of reactions of the neurohumoral regulation system is triggered and, first of all, the sympathoadrenal system is activated with an increase in the catecholamine production, the development of tachycardia. Due to this, the level of brain natriuretic peptide in the blood is increased. In children, chronic heart failure is asymptomatic. Therefore, determining tolerance to physical exertion plays an important role in its diagnosis. The purpose was to determine the functional state of the cardiovascular system and the tolerance to physical exertion in adolescents with JIA, taking into account the level of catecholamine excretion in the daily urine and the level of natriuretic peptide in the blood. Materials and methods. Fifty-six patients with JIA aged 12–17 years (13.28 ± 0.38 years) were examined. The control group consisted of 46 apparently healthy peers of the corresponding age. A heart ultrasound was performed to establish the functional state of the myocardium. To study tolerance to physical exertion, a six-minute walk test was performed with calculation of Kerdo index before and after the test. The level of catecholamine excretion in the urine and the level of natriuretic peptide in the blood were studied. Results. Patients with juvenile idiopathic arthritis had early signs of right ventricular myocardial systolic dysfunction (a decrease in the right ventricular ejection fraction). At the same time, we detected a decrease in the catecholamine level and an increase in the content of natriuretic peptide, which has a neuromodulatory effect at different levels of the sympathoadrenal system. Conclusions. Activation of the sympathetic division of the autonomic nervous system (increased Kerdo index) in patients with juvenile idiopathic arthritis does not ensure the effectiveness of minimal physical exertion in a six-minute walk test.

show abstract

Adaptive capacity of the cardiovascular system in children with rheumatic diseases and comorbid conditions

Cited by 3 publications

References 7 publications

Comorbidity in children with rheumatic diseases: literature review and 10-year experience of own research

Comorbidity in children with rheumatic diseases: literature review and 10-year experience of own research

Prognostic value of serum soluble ST2 in professional athletes (Valor pronóstico de ST2 soluble en suero en deportistas profesionales)

Adaptive capabilities of the cardiovascular system, taking into account regulation systems, in adolescents with juvenile idiopathic arthritis

Contact Info

Product

Resources

About