Adaptation to Periodic Hypoxia and Hyperoxia Improves Resistance of Membrane Structures in Heart, Liver, and Brain

Arkhipenko, Yu. V.; Сазонтова, Т. Г.; Zhukova, Anna G.

doi:10.1007/s10517-005-0466-0

Cited by 28 publications

(27 citation statements)

References 8 publications

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“…The rationale for using 95% O 2 has been to avert tissue hypoxia; however, in the process, the tissue sustains "chronic" hyperoxia, which increases ROS production, stimulates neural activity, and increases cell death (22). Another potential concern is that sustained exposure to hyperoxia may be inducing oxidative preconditioning, thereby blunting subsequent neuronal responses to O 2 manipulation and ROS production and confounding the results of the study (4,10,37,69).…”

Section: O 2 Toxicity Occurs Under What Conditions?mentioning

confidence: 99%

“…Membrane stabilization under conditions of oxidative stress is one strategy to delay the onset of CNS O 2 toxicity (seizures). Endogenous antioxidant mechanisms can be augmented through oxidative preconditioning (4,37,69), and this may enhance protection against O 2 toxicity (10). A potentially effective countermeasure against O 2 toxicity could be the use of exogenous antioxidants in conjunction with various protocols of oxidative preconditioning, but this hypothesis will need to be tested.…”

Section: O 2 Toxicity Occurs Under What Conditions?mentioning

confidence: 99%

“…Ion channel gating could be affected directly by redox mechanisms, or indirectly by membrane perturbations involving 1) oxidation of membrane-cytoskeletal bonds; 2) distortion via membrane lipid peroxidation and blebbing (21); and/or 3) membrane expansion as molecular O 2 diffuses into the bilayer as dictated by its relatively high lipid solubility (8). In future studies, it will be important to identify the subtle, graded effects of ROS/RNS on membrane structure and function over a continuum of PO 2 that spans normoxia through hyperoxia to identify the potentially therapeutic, neuroprotective effects of redox stimuli (4,10,33,37) vs. their deleterious effects in O 2 toxicity (3).…”

Section: O 2 Toxicity Occurs Under What Conditions?mentioning

confidence: 99%

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Effects of hyperbaric gases on membrane nanostructure and function in neurons

D’Agostino¹,

Colomb²,

Dean³

2009

Journal of Applied Physiology

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D'Agostino DP, Colomb DG Jr, Dean JB. Effects of hyperbaric gases on membrane nanostructure and function in neurons. J Appl Physiol 106: 996 -1003, 2009. First published September 27, 2008 doi:10.1152/japplphysiol.91070.2008.-This mini-review summarizes current ideas of how hyperbaric gases (Ͼ1-10 atmospheres absolute) affect neuronal mechanisms of excitability through molecular interaction with membrane components. The dynamic nature of the lipid bilayer, its resident proteins, and the underlying cytoskeleton make each respective nanostructure a potential target for modulation by hyperbaric gases. Depending on the composition of the gas mixture, the relative concentrations of O 2 and inert gas, and total barometric pressure, the net effect of a particular gas on the cell membrane will be determined by the gas' 1) lipid solubility, 2) ability to oxidize lipids and proteins (O 2), and 3) capacity, in the compressed state, to generate localized shear and strain forces between various nanostructures. A change in the properties of any one membrane component is anticipated to change conductance of membrane-spanning ion channels and thus neuronal function.anesthesia; barosensitivity; free radicals; inert gas narcosis; nitrogen narcosis; oxidative stress; oxygen toxicity THE RANGE OF HYPERBARIC PRESSURE that humans can survive, without protection from a sealed 1-atmosphere pressure suit or submersible, extends from just beneath sea level [1 atmosphere absolute (ATA) 1 ] down to a maximum pressure of ϳ70 ATA, which is equivalent to ϳ2,300 feet of seawater (fsw) (26, 30). 2The caveat, of course, is that the aquanaut descending over this continuum of increasing ambient pressure must use specialized breathing equipment that delivers gas to their lungs at a pressure equivalent to ambient pressure. The level of inspired O 2 and the mixture of balance gases have to be selected carefully for the desired depth to avoid the powerful, wideranging, but harmful effects on neurological function of breathing hyperbaric O 2 (HBO 2 ) and hyperbaric N 2 (HBN 2 ). This means decreasing the fractional concentration of N 2 in air to Ͻ0.79 to avert the euphoric irrationality of inert gas narcosis (IGN), otherwise known as N 2 narcosis, and carefully regulating inspired O 2 to avoid the violent, uncontrollable seizures of central nervous system (CNS) O 2 toxicity (reviewed in Ref. 30). At even greater depths, in the absence of CNS O 2 toxicity and IGN, diver performance can still be impaired by a constellation of debilitating symptoms known collectively as highpressure nervous syndrome (HPNS), which includes, but is not limited to, muscular tremors, loss of coordination and memory deficits (30,84).In each case, hyperbaria is the requisite condition for induction and maintenance of neurological dysfunction. The diversity of molecular and cellular mechanisms responsible for each neurological condition is readily apparent when the suspected underlying causes are considered: CNS O 2 toxicity is attributed to the harmful effects of various sp...

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Section: O 2 Toxicity Occurs Under What Conditions?mentioning

confidence: 99%

Section: O 2 Toxicity Occurs Under What Conditions?mentioning

confidence: 99%

Section: O 2 Toxicity Occurs Under What Conditions?mentioning

confidence: 99%

See 1 more Smart Citation

Effects of hyperbaric gases on membrane nanostructure and function in neurons

D’Agostino¹,

Colomb²,

Dean³

2009

Journal of Applied Physiology

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“…Recently, a new mode of adaptive training was explored, which combines periods of hypoxia and hyperoxia [66][67][68][69]. A novel principle of short-term periodic adaptive training by varying the oxygen level from hypo-to hyperoxia is substantiated both theoretically and experimentally.…”

Section: Hypoxic-hyperoxic Exposuresmentioning

confidence: 99%

Fitness and therapeutic potential of intermittent hypoxia training: a matter of dose

Serebrovska¹,

Serebrovska²,

Egorov³

2016

Fiziol Zh

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“…Recently, a new mode of adaptive training was explored, which combines periods of hypoxia and hyperoxia [122][123][124][125]. A novel principle of short-term periodic adaptive training by varying the oxygen level from hypo-to hyperoxia is substantiated both theoretically and experimentally.…”

Section: Use Of Iht In Cardiac Clinicmentioning

confidence: 99%