Remote ischemic preconditioning versus intermittent hypoxia training: a comparative analysis for cardioprotection

Serebrovska, Tetiana V.; Shatilo, Valeri

doi:10.15407/fz61.03.099

Cited by 7 publications

(5 citation statements)

References 113 publications

(143 reference statements)

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“…96,97,100,193,194 Further information on the cardioprotective effects of IHT are available in the recent reviews by Zhang and Zhou 195 and by Serebrovska and Shatilo. 196 Various antistress effects of IHT have been described by IHT pioneer Felix Meerson. 179 He and his co-workers found that IHT prevented stomach ulcers induced by restraint stress and behavioral disorders in rats.…”

Section: Intermittent Hypoxic Training (Iht) Improves Cerebrovascularmentioning

confidence: 99%

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Манухина

Downey

Shi

et al. 2016

Exp Biol Med (Maywood)

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Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently there are no definitive therapies for treatment or prevention of AD, reduction of VRFs lowers the risk for cognitive decline. There is increasing evidence that brief repeated exposures to moderate hypoxia, i.e. intermittent hypoxic training (IHT), improve cerebral vascular function and reduce VRFs including systemic hypertension, cardiac arrhythmias, and mental stress. In experimental AD, IHT nearly prevented endothelial dysfunction of both cerebral and extra-cerebral blood vessels, rarefaction of the brain vascular network, and the loss of neurons in the brain cortex. Associated with these vasoprotective effects, IHT improved memory and lessened AD pathology. IHT increases endothelial production of nitric oxide (NO), thereby increasing regional cerebral blood flow and augmenting the vaso-and neuroprotective effects of endothelial NO. On the other hand, in AD excessive production of NO in microglia, astrocytes, and cortical neurons generates neurotoxic peroxynitrite. IHT enhances storage of excessive NO in the form of S-nitrosothiols and dinitrosyl iron complexes. Oxidative stress plays a pivotal role in the pathogenesis of AD, and IHT reduces oxidative stress in a number of experimental pathologies. Beneficial effects of IHT in experimental neuropathologies other than AD, including dyscirculatory encephalopathy, ischemic stroke injury, audiogenic epilepsy, spinal cord injury, and alcohol withdrawal stress have also been reported. Further research on the potential benefits of IHT in AD and other brain pathologies is warranted.

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Section: Intermittent Hypoxic Training (Iht) Improves Cerebrovascularmentioning

confidence: 99%

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Манухина

Downey

Shi

et al. 2016

Exp Biol Med (Maywood)

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“…Hypoxic preconditioning (HPC) or ischemic preconditioning (IPC) can improve the tolerance of cells, tissues, entire organs, and even the organism itself to subsequent severe hypoxia or ischemia [6–8]. The phenomenon of preconditioning has been observed in various studies [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Hypoxia preconditioning attenuates lung injury after thoracoscopic lobectomy in patients with lung cancer: a prospective randomized controlled trial

Zhang

Chen

et al. 2019

BMC Anesthesiol

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BackgroundHypoxic preconditioning (HPC) may protect multiple organs from various injuries. We hypothesized that HPC would reduce lung injury in patients undergoing thoracoscopic lobectomy.MethodsIn a prospective randomized controlled trial, 70 patients undergoing elective thoracoscopic lobectomy were randomly allocated to the HPC group or the control group. Three cycles of 5-min hypoxia and 3-min ventilation applied to the nondependent lung served as the HPC intervention. The primary outcome was the PaO2/FiO2 ratio. Secondary outcomes included postoperative pulmonary complications, pulmonary function, and duration of hospital stay.ResultsHPC significantly increased the PaO2/FiO2 ratio compared with the control at 30 min after one-lung ventilation and 7 days after operation. Compared with the control, it also significantly improved postoperative pulmonary function and markedly reduced the postoperative hospital stay duration. No significant differences between groups were observed in the incidence of pulmonary complications or overall postoperative morbidity.ConclusionsHPC improves postoperative oxygenation, enhances the recovery of pulmonary function, and reduces the duration of hospital stay in patients undergoing thoracoscopic lobectomy.Trial registrationThis study was registered in the Chinese Clinical Trial Registry (ChiCTR-IPR-17011249) on April 27, 2017.

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“…Remote ischemic preconditioning (RIPC) is a nonpharmacological therapeutic strategy to protect vascular function through intermittent ischemia. RIPC initiates alternate and intermittent episodes of ischemia by cutting off blood flow to nontarget tissue (often the arms or legs) [26]. Moreover, numerous clinical trials have already supported RIPC's anti-ischemic protective effects on the heart, brain, and other important organs [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Helpful to Live Healthier? Intermittent Hypoxic/Ischemic Training Benefits Vascular Homeostasis and Lipid Metabolism with Activating SIRT1 Pathways in Overweight/Obese Individuals

Jiao,

Liu,

et al. 2024

Obes Facts

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Introduction: The present study aimed to investigate whether and how normobaric intermittent hypoxic training (IHT) or remote ischemic preconditioning (RIPC) plus normoxic training (RNT) has a synergistic protective effect on lipid metabolism and vascular function compared with normoxic training (NT) in overweight or obese adults. Methods: A total of 37 overweight or obese adults (36.03 ± 10.48 years) were randomly assigned to 3 groups: NT group (exercise intervention in normoxia), IHT group (exercise intervention in normobaric hypoxic chamber) and RNT group (exercise intervention in normoxia + RIPC twice daily). All participants carried out the same one-hour exercise intervention for a total of four weeks, five days per week. Physical fitness parameters were evaluated at pre- and post-exercise intervention. Results: After training, all three groups significantly decreased BMI (p < 0.05). IHT group reduced body fat percentage, visceral fat mass (p < 0.05), blood pressure (p < 0.01), left ABI, HRmax (p < 0.05), the expression of PPARγ (p < 0.01), and increased the expression of SIRT1 (p < 0.05), VEGF (p < 0.01). RNT group lowered waist-to-hip ratio, visceral fat mass, blood pressure (p < 0.05) and HRmax (p < 0.01). Conclusion: IHT could effectively reduce visceral fat mass and improve vascular elasticity in overweight or obese individuals than pure normoxic training with the activation of SIRT1-related pathways. And RNT also produced similar benefits on body composition and vascular function, which were weaker than those of IHT but stronger than normoxic training. Given the convenience and economy of RNT, both intermittent hypoxic and ischemic training have the potential to be a successful health promotion strategies for the overweight/obese population.

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Remote ischemic preconditioning versus intermittent hypoxia training: a comparative analysis for cardioprotection

Abstract: Ischemic preconditioning (IPC) is an adaptive phenomenon that occurs

Cited by 7 publications

References 113 publications

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease

Hypoxia preconditioning attenuates lung injury after thoracoscopic lobectomy in patients with lung cancer: a prospective randomized controlled trial

Helpful to Live Healthier? Intermittent Hypoxic/Ischemic Training Benefits Vascular Homeostasis and Lipid Metabolism with Activating SIRT1 Pathways in Overweight/Obese Individuals

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