Fitness and therapeutic potential of intermittent hypoxia training: a matter of dose

Serebrovska, Tetiana V.; Serebrovska, Zoya; Egorov, Egor

doi:10.15407/fz62.03.078

Cited by 32 publications

(37 citation statements)

References 56 publications

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“…As discussed above, the wide difference in effects that have been reported in the literature can be explained by individual susceptibility and the diversity of intermittent hypoxia patterns applied (Debevec and Mekljavic, 2013 ). The adaptive or maladaptive responses can be due to differences in the frequency, severity or duration of hypoxic episodes (Serebrovska et al, 2016 ). Factors such as age, sex or genotypic variability may also contribute to varying results (Almendros et al, 2014 ).…”

Section: Intermittent Hypoxia In Sportmentioning

confidence: 99%

Physiological and Biological Responses to Short-Term Intermittent Hypobaric Hypoxia Exposure: From Sports and Mountain Medicine to New Biomedical Applications

et al. 2018

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In recent years, the altitude acclimatization responses elicited by short-term intermittent exposure to hypoxia have been subject to renewed attention. The main goal of short-term intermittent hypobaric hypoxia exposure programs was originally to improve the aerobic capacity of athletes or to accelerate the altitude acclimatization response in alpinists, since such programs induce an increase in erythrocyte mass. Several model programs of intermittent exposure to hypoxia have presented efficiency with respect to this goal, without any of the inconveniences or negative consequences associated with permanent stays at moderate or high altitudes. Artificial intermittent exposure to normobaric hypoxia systems have seen a rapid rise in popularity among recreational and professional athletes, not only due to their unbeatable cost/efficiency ratio, but also because they help prevent common inconveniences associated with high-altitude stays such as social isolation, nutritional limitations, and other minor health and comfort-related annoyances. Today, intermittent exposure to hypobaric hypoxia is known to elicit other physiological response types in several organs and body systems. These responses range from alterations in the ventilatory pattern to modulation of the mitochondrial function. The central role played by hypoxia-inducible factor (HIF) in activating a signaling molecular cascade after hypoxia exposure is well known. Among these targets, several growth factors that upregulate the capillary bed by inducing angiogenesis and promoting oxidative metabolism merit special attention. Applying intermittent hypobaric hypoxia to promote the action of some molecules, such as angiogenic factors, could improve repair and recovery in many tissue types. This article uses a comprehensive approach to examine data obtained in recent years. We consider evidence collected from different tissues, including myocardial capillarization, skeletal muscle fiber types and fiber size changes induced by intermittent hypoxia exposure, and discuss the evidence that points to beneficial interventions in applied fields such as sport science. Short-term intermittent hypoxia may not only be useful for healthy people, but could also be considered a promising tool to be applied, with due caution, to some pathophysiological states.

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Section: Intermittent Hypoxia In Sportmentioning

confidence: 99%

Physiological and Biological Responses to Short-Term Intermittent Hypobaric Hypoxia Exposure: From Sports and Mountain Medicine to New Biomedical Applications

et al. 2018

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“…HC is a drug-free method based on the adaptation produced by breathing air with low oxygen content [4]. During the last 30 years, HC interventions have enhanced physical and mental functions and the prevention of aging and different diseases in two million patients [13]. HC can be implemented with different patterns and severity, mediating different molecular pathways [14].…”

Section: Introductionmentioning

confidence: 99%

Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review

Camacho-Cardeñosa

Timón

et al. 2019

IJERPH

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Among other functions, hypoxia-inducible factor plays a critical role in bone–vascular coupling and bone formation. Studies have suggested that hypoxic conditioning could be a potential nonpharmacological strategy for treating skeletal diseases. However, there is no clear consensus regarding the bone metabolism response to hypoxia. Therefore, this review aims to examine the impact of different modes of hypoxia conditioning on bone metabolism. The PubMed and Web of Science databases were searched for experimental studies written in English that investigated the effects of modification of ambient oxygen on bone remodelling parameters of healthy organisms. Thirty-nine studies analysed the effect of sustained or cyclic hypoxia exposure on genetic and protein expression and mineralisation capacity of different cell models; three studies carried out in animal models implemented sustained or cyclic hypoxia; ten studies examined the effect of sustained, intermittent or cyclic hypoxia on bone health and hormonal responses in humans. Different modes of hypoxic conditioning may have different impacts on bone metabolism both in vivo and in vitro. Additional research is necessary to establish the optimal cyclical dose of oxygen concentration and exposure time.

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“…The release of various vasodilators such as adenosine, prostaglandin, and NO during exercise contributes to the mechanism responsible for vasodilation. Particularly, hypoxia induces an increase in NO bioavailability resulting in vasodilation and a reduction in total systemic vascular resistance and thereby BP [ 37 , 38 ]. Moreover, an exercise under moderate hypoxia induces a reduction in arterial stiffness and the activity of the sympathetic nervous system, relaxation of blood vessels, and improvement of blood flow and hemorheological functions such as erythrocyte deformability and aggregation [ 10 , 13 , 14 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Hypoxic Pilates Intervention for Obesity: A Randomized Controlled Trial

Jung

Kim

Park

et al. 2020

IJERPH

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This study examined the effect of Pilates training under hypoxia, a novel treatment method, for obesity. Thirty-two Korean women with obesity (age: 34–60 (47.5 ± 7.5) years) were randomly assigned to control (CON; n = 10), normoxic Pilates training (NPTG; n = 10), and hypoxic Pilates training groups (HPTG; n = 12). The NPTG and HPTG performed 50 min of Pilates training using a tubing band for 12 weeks (3 days/week) in their respective environmental conditions (NPTG: normoxic condition, inspired oxygen fraction (FiO2) = 20.9%; HPTG: moderate hypoxic condition, FiO2 = 14.5%). The CON maintained their daily lifestyle without intervention. All subjects underwent body composition, blood pressure, arterial stiffness, vascular endothelial function, cardiometabolic biomarker, hemorheological function, and aerobic performance measurements before and after the intervention. The HPTG showed a significant improvement in diastolic blood pressure, total cholesterol and triglyceride concentrations, flow-mediated dilation, and erythrocyte deformability and aggregation (all p < 0.05) compared with the CON and NPTG. However, compared with the CON and NPTG, the HPTG did not show improvement in other parameters. Hypoxic Pilates intervention is a novel and successful method for promoting endothelial and hemorheological functions in women with obesity.

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Fitness and therapeutic potential of intermittent hypoxia training: a matter of dose

Abstract: The introduction of different methods of intermittent hypoxic training (IHT) into fitness

Cited by 32 publications

References 56 publications

Physiological and Biological Responses to Short-Term Intermittent Hypobaric Hypoxia Exposure: From Sports and Mountain Medicine to New Biomedical Applications

Physiological and Biological Responses to Short-Term Intermittent Hypobaric Hypoxia Exposure: From Sports and Mountain Medicine to New Biomedical Applications

Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review

Hypoxic Pilates Intervention for Obesity: A Randomized Controlled Trial

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