Acyclic Polyacetals from Polysaccharides: Biomimetic Biomedical "Stealth" Polymers

Papisov, Mikhail

doi:10.1021/bk-2001-0786.ch019

Cited by 6 publications

(12 citation statements)

References 17 publications

(18 reference statements)

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“…Papisov et al proposed to use acyclic hydrophilic polyacetals (Fig. 7) derived from polycarbohydrates to replace PEG 140. The advantages of hydrophilic polyacetals, as compared with PEG, are biodegradability and availability of readily modifiable functional groups 140.…”

Section: Alternative Strategies For Protecting Np Surfacesmentioning

confidence: 99%

“…140 The advantages of hydrophilic polyacetals, as compared with PEG, are biodegradability and availability of readily modifiable functional groups. 140 Moreover, a polylysine grafted with polyacetal had a much longer blood half-life than a polylysine grafted with dextran, the original polysaccharide that polyacetal was derived from. 140 This difference was attributed to the elimination of rigid stereospecific structures of dextran.…”

Section: Polysaccharidesmentioning

confidence: 99%

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Recent advances in stealth coating of nanoparticle drug delivery systems

Amoozgar

Yeo

2012

WIREs Nanomed Nanobiotechnol

404

290

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Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so called PEGylation, is the most commonly used method for reducing premature clearance of NPs from the circulation. However, several reports point out that PEGylation may negatively influence the performance of NPs as a drug carrier. Alternative surface modification strategies, including substitute polymers, conditional removal of PEG, and biomimetic surface modification, may provide solutions for the limitations of PEG.

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Section: Alternative Strategies For Protecting Np Surfacesmentioning

confidence: 99%

Section: Polysaccharidesmentioning

confidence: 99%

Recent advances in stealth coating of nanoparticle drug delivery systems

Amoozgar

Yeo

2012

WIREs Nanomed Nanobiotechnol

404

290

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“…The second stage is glycyl ester bond hydrolysis, which results in active drug release in vivo. The conjugate was assembled using poly(1-hydroxymethylethylene hydroxy-methyl formal) (PHF) as a backbone, which is a highly hydrophilic biodegardable polymer [97,98].…”

Section: Conjugated Analogsmentioning

confidence: 99%

Review Camptothecin: Current Perspectives

Zu²,

Shi³

et al. 2006

CMC

244

117

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The review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor agent that targets topoisomerase I. Thousands of CPT derivatives have been synthesized. Two of them, Topotecan and Irinotecan, are commercially approved for use in clinic as antitumor agents while more are still in clinic trials. This review summarizes the current status of the modern synthetic approaches to CPT, the mechanism of action of CPT, the structure-activity relationship(SAR), a number of novel CPT analogs and their biologic activity. There is a systematic evaluation of A-, B- and E-ring- modified camptothecins reported recently.

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“…1 H nuclear magnetic resonance spectra was recorded with a Bruker Avarice TM 500 NMR spectrometer. For NMR measurement, concentration of the sample was 35 mg/mL in DMSO-d 6 . The particle sizes and size distributions of mPEG-graft-PAA-CPT conjugate micelles were measured by dynamic light scattering (Zetasizer Nano ZS, Malvern Instruments, UK).…”

Section: Characterization and Measurementsmentioning

confidence: 99%

“…To improve the solubility and stability of CPT in aqueous media, poly (ethylene glycol) (PEG) [5], poly (1-hydroxymethylethylene hydroxyl-methyl formal) (PHF) [6], poly[N-(2-hydroxypropyl) methacrylamide] (HPMA) [7], dextran [8], and poly (l-glutamic acid) (PGA) [9] have been reported to conjugate with CPT. Recently, PEGylated copolymers are attractive particularly due to their biocompatibility and biodegradability as biomaterials and drug delivery vehicles [10].…”

Section: Introductionmentioning

confidence: 99%