Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated α,β-poly (l-aspartic acid)-camptothecin conjugate

Zhang, Weilu; Huang, Jin; Fan, Naiqian; Yu, Jiahui; Liu, Yong‐Biao; Liu, Shiyuan; Wang, Daxin; Li, Yaping

doi:10.1016/j.colsurfb.2010.07.019

Cited by 27 publications

(8 citation statements)

References 31 publications

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“…Another nanomicelle system was developed by using α,β-poly[(N-carboxybutil)-Laspartamide] (PBAsp) with different CPT loading (PBAsp-CPT), through esterification between PBAsp carboxyl groups and CPT 20-hydroxyl [90][91] (Fig. 3).…”

Section: Micellesmentioning

confidence: 99%

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Botella

Rivero-Buceta

2017

Journal of Controlled Release

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Twenty-(S)-camptothecin is a strongly cytotoxic molecule with excellent antitumor activity over a wide spectrum of human cancers. However, the direct formulation is limited by its poor water solubility, low plasmatic stability and severe toxicity, which currently limits its clinical use. As a consequence, two strategies have been developed in order to achieve safe and efficient delivery of camptothecin to target cells: structural analogues and nanomedicines. In this review, we summarize recent advances in the design, synthesis and development of camptothecin molecular derivatives and supramolecular vehicles, following a systematic classification according to structure-activity relationships (structural analogues) or chemical nature (nanomedicines). A series of organic, inorganic and hybrid materials are presented as nanoplatforms to overcome camptothecin restrictions in administration, biodistribution, pharmacokinetics and toxicity. Nanocarriers which respond to a variety of stimuli endogenously (e.g., pH, redox potential, enzyme activity) or exogenously (e.g., magnetic field, light, temperature, ultrasound) seem the best positioned therapeutic materials for optimal spatial and temporal control over drug release. The main goal of this review is to be used as a source of relevant literature for others interested in the field of camptothecin-based therapeutics. To this end, final remarks on the most important formulations currently under clinical trial are provided.

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Section: Micellesmentioning

confidence: 99%

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Botella

Rivero-Buceta

2017

Journal of Controlled Release

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“…The critical micelle concentration (CMC) of both micelles was determined by fluorescence spectroscopy with pyrene as a fluorescence probe [23] . The concentration of pyrene probe in acetone was 2 × 10 −6 m .…”

Section: Methodsmentioning

confidence: 99%

Chirality plays critical roles in enhancing the aqueous solubility of nocathiacin I by block copolymer micelles

Feng

Wang

et al. 2012

Journal of Pharmacy and Pharmacology

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“…Such a formulation will add two steps for the release of the drug. First, the drug is released from the polymer through enzyme hydrolysis or other means of breakdown and second, the drug is released via diffusion of the drug out of the micelles, with the former typically being the rate-limiting step 17 . A major advantage of this method is that the drug remains in the micelle for a long period of time due to conjugation.…”

Section: Fig 2: Showing the Formation Of Pic Nano-micellementioning

confidence: 99%

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2018

IJPSR

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ABSTRACT:In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as 'smart drug carriers' for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. In present scenario, the major challenge for the researchers is ocular drug delivery system as eye is the most sensitive organ in our body. Topical eye drop is the best suited way for delivery of drugs for the treatment of anterior segment of the eye. Delivery of the drugs to the targeted areas is restricted by the various barriers and even the amount instilled do not remain there for a long duration of time. In the past many years scientist are working on providing the masses the way for delivering drug in a novel, safe and patience compliance manner. The aided the basic delivery by providing the administration through various permeation enhancers and viscosity modifiers. Widely studied subjects in nanoscience technology is related to the conception of supramolecular architectures with well-defined structures and functionalities. Nanomicelles have congregated considerable attention in the field of drug and ocular drug delivery due to their exceptional biocompatibility, low toxicity, enhanced blood circulation time.

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Nanomicelle with long-term circulation and enhanced stability of camptothecin based on mPEGylated α,β-poly (l-aspartic acid)-camptothecin conjugate

Cited by 27 publications

References 31 publications

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Chirality plays critical roles in enhancing the aqueous solubility of nocathiacin I by block copolymer micelles

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