Acute withdrawal induced by adenosine A<sub>1</sub>-receptor activation in isolated guinea-pig ileum: role of opioid receptors and effect of cholecystokinin

Marini, Pietro; Romanelli, L.; Valeri, Daniela; Tucci, Paolo; Valeri, P.; Palmery, Maura

doi:10.1211/jpp.62.05.0010

Cited by 6 publications

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References 69 publications

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“…The experimental procedure has been described previously (10). Six male guineapigs weighing 300-400 g (aged 2-3 months, provided by Morini, Italy) were housed in groups with food and water available ad libitum, in a room with controlled temperature (22 ± 1 °C) and under artifi cial 12-h light/12-h dark cycle for at least 4 days before use.…”

Section: Animals Tissue Preparation and In Vitro Toolsmentioning

confidence: 99%

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

et al. 2015

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The presence of vitamin D receptors in small intestine muscle cells may lead one to think that vitamin D may act locally, infl uencing intracellular calcium concentration and contributing to the contraction-relaxation regulation of the intestinal smooth muscle cells. This study investigates the potential eff ects of vitamin D and calcium on intestinal motility using an in vitro test. ) was added aft er at least 3 hours, it evoked evident and persistent contractions for 60-90 minutes. The contractions were at about 40 % of the peak produced by acetylcholine. Thus, simultaneous intake of vitamin D and calcium might be a useful co-adjuvant in intestinal atony therapy aimed to stimulate normal gut motility in humans. These fi ndings imply that supplemental vitamin D may be important in all cases where calcium has to be prescribed. Health consequences of vitamin D defi ciency are important; recent studies confi rm that vitamin D defi ciency is widespread in children and elderly people (3, 4). Vitamin D

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Section: Animals Tissue Preparation and In Vitro Toolsmentioning

confidence: 99%

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

et al. 2015

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Endogenous opiates and behavior: 2010

Bodnar

2011

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The NOP receptor involvement in both withdrawal- and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ-opioid receptor

Marini

Romanelli²,

Valeri³

et al. 2012

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Acute withdrawal induced by adenosine A₁-receptor activation in isolated guinea-pig ileum: role of opioid receptors and effect of cholecystokinin

Abstract: In guinea-pig ileum, stimulation of the A(1) system indirectly activates both mu- and kappa-opioid systems; this indirect activation is significantly, albeit not completely, antagonised by CCk-8. Cross dependence between A(1) and opioid systems was also observed.

Cited by 6 publications

References 69 publications

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

Endogenous opiates and behavior: 2010

The NOP receptor involvement in both withdrawal- and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ-opioid receptor

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Acute withdrawal induced by adenosine A1-receptor activation in isolated guinea-pig ileum: role of opioid receptors and effect of cholecystokinin

Abstract: In guinea-pig ileum, stimulation of the A(1) system indirectly activates both mu- and kappa-opioid systems; this indirect activation is significantly, albeit not completely, antagonised by CCk-8. Cross dependence between A(1) and opioid systems was also observed.

Cited by 6 publications

References 69 publications

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

Investigation of the effects of vitamin D and calcium on intestinal motility: In vitro tests and implications for clinical treatment

Endogenous opiates and behavior: 2010

The NOP receptor involvement in both withdrawal- and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ-opioid receptor

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Acute withdrawal induced by adenosine A₁-receptor activation in isolated guinea-pig ileum: role of opioid receptors and effect of cholecystokinin