The NOP receptor involvement in both withdrawal- and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of κ-opioid receptor

Marini, Pietro; Romanelli, L.; Valeri, Daniela; Cascio, Maria Grazia; Tucci, Paolo; Valeri, P.; Palmery, Maura

doi:10.1016/j.peptides.2012.09.028

“…Activation of receptors of opioids in the GI tract is responsible for inhibition of gut motility, whereas the receptors in the central nervous system mediate analgesia (15). The μ-, κ-, and δ-opioid receptors have been found in the GI tracts of rodents and humans, but their relative distribution is altered according various GI layers, GI regions and species (16,17). In the human gut, μ-opioid receptors are located at the neurons of submucosa and myenteron and at immune cells in the lamina propria (18), while κ-opioid receptors are present on excitatory and inhibitory motor neurons (19).…”

Section: Discussionmentioning

confidence: 99%

Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial

Chen

¹

,

Tian

²

,

Zhang

³

et al. 2020

Clin Exp Pharma Physio

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Background The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynecological malignancies. Methods A total of 100 patients aged between 18-70 years with American Society of Anesthesiologists (ASA) physical status I-II who scheduled for laparoscopic radical hysterectomy under general anaesthesia were enrolled. Patients were randomized to receive either sufentanil (Group S) or nalbuphine (Group N) to receive either sufentanil (Group S) or nalbuphine (Group N) in the intraoperative and postoperative periods. The time to the first passage of flatus, the time to the first defecation, the time to the toleration of diet, the serum gastrin and the length of hospital stay were compared between the groups. Postoperative pain by visual analogue scale (VAS), the number of PCA(patient-controlled analgesia)s, postoperative nausea and vomiting, and dizziness were compared between the groups. Results The time to the first passage of flatus(p =0.551), the time to the first defecation(p =0.310), the time to the toleration of diet(p =0.182), the serum gastrin(p =0.397), the number of postoperative nausea(p =0.920), vomit(p =0.334) and PCA events(p =0.167) and the length of hospital stay(p =0.482) were not significantly different between the two groups. VAS scores at postoperative 6 h(p=0.008), 12 h(p =0.002) and 24 h(p =0.013) were lower in Group N than in Group S. Conclusions Compared with sufentanil, nalbuphine was not associated with improved postoperative GI dysfunction after laparoscopic surgery for gynecological malignancies, but it was associated with reduced postoperative pain. Background Postoperative gastrointestinal (GI) dysfunction such as nausea, vomiting, inability to eat, deflation, prolonged bowel movements, and paralytic ileus are some of the most common complications after surgery, and the incidence is nearly 10-30%(1). The occurrence of postoperative GI dysfunction leads

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“…Activation of receptors of opioids in the GI tract is responsible for inhibition of gut motility, whereas the receptors in the central nervous system mediate analgesia (15). The μ-, κ-, and δ-opioid receptors have been found in the GI tracts of rodents and humans, but their relative distribution is altered according various GI layers, GI regions and species (16,17). In the human gut, μ-opioid receptors are located at the neurons of submucosa and myenteron and at immune cells in the lamina propria (18), while κ-opioid receptors are present on excitatory and inhibitory motor neurons (19).…”

Section: Discussionmentioning

confidence: 99%

Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynecological malignancies: a randomized controlled trial

Chen

¹

,

Tian

²

,

Zhang

³

et al. 2019

Preprint

1

0

View full text Add to dashboard Cite

Background The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynecological malignancies. Methods A total of 100 patients aged between 18-70 years with American Society of Anesthesiologists (ASA) physical status I-II who scheduled for laparoscopic radical hysterectomy under general anaesthesia were enrolled. Patients were randomized to receive either sufentanil (Group S) or nalbuphine (Group N) to receive either sufentanil (Group S) or nalbuphine (Group N) in the intraoperative and postoperative periods. The time to the first passage of flatus, the time to the first defecation, the time to the toleration of diet, the serum gastrin and the length of hospital stay were compared between the groups. Postoperative pain by visual analogue scale (VAS), the number of PCA(patient-controlled analgesia)s, postoperative nausea and vomiting, and dizziness were compared between the groups. Results The time to the first passage of flatus(p =0.551), the time to the first defecation(p =0.310), the time to the toleration of diet(p =0.182), the serum gastrin(p =0.397), the number of postoperative nausea(p =0.920), vomit(p =0.334) and PCA events(p =0.167) and the length of hospital stay(p =0.482) were not significantly different between the two groups. VAS scores at postoperative 6 h(p=0.008), 12 h(p =0.002) and 24 h(p =0.013) were lower in Group N than in Group S. Conclusions Compared with sufentanil, nalbuphine was not associated with improved postoperative GI dysfunction after laparoscopic surgery for gynecological malignancies, but it was associated with reduced postoperative pain.

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“…The contractile effect of N/OFQ on colonic smooth muscle is partially mediated by the inhibition of the tonic, neuronal release of nitrogen oxide (Menzies & Corbett, 2000). The N/OFQ system acts as a neuromodulatory system strictly relating to the modulation of excitatory or inhibitory neurotransmitters released in the guinea pig ileum enteric nervous system (Marini et al, 2012). NOP-R mRNA is detectable in the jejunum and colon of healthy subjects and is more highly expressed in the jejunum than in the colon.…”

Section: Intestinal Smooth Musclementioning

confidence: 99%