ACUTE TOXICITY STUDY FOR MELAMINE ON JAPANESE SEA BASS(&lt;I&gt;LATEOLABRAX JAPONICUS&lt;/I&gt;)

Liu, Haiyan; Zhang, Wei; Xue, Mei; Wu, Xiufeng; Zheng, Yi; Guo, Liya; HongJian, Sheng

doi:10.3724/sp.j.1035.2009.00157

Cited by 9 publications

(7 citation statements)

References 5 publications

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“…This suggests, since combined MEL-CYA adversely affected the growth of Asian sea bass, that this sea bass is more sensitive to MEL-CYA than the red tilapia. Our results corroborate those in the studies of Liu et al (2009) and Xue et al (2011) assessing the toxicity of MEL to Japanese seabass (Lateolabrax japonicus) and to darkbarbel catfish (P. vachelli), respectively. However, no atypical findings, such as color alterations of skin or other anomalies, were observed in the current study on MEL or its derivative as feed adulterants.…”

Section: Discussionsupporting

confidence: 93%

“…Pirarat et al (2012) also reported that the administration of high 10:10 doses of combined MEL and CYA increased serum alanine transaminase and aspartate transaminase in catfish, indicating abnormal liver function. Similarly, Liu et al (2009) reported that feeding 10 g of melamine per kg feed increased alkaline phosphatase levels in Japanese sea bass, whereas alanine transaminase and aspartate aminotransferase activities were not influenced. The results in our present study agree with those of Phromkunthong et al (2013) where lesions in liver appeared in tilapia receiving melamine in the diet.…”

Section: Parametersmentioning

confidence: 93%

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A study on growth, histopathology and oxidative stress in Asian sea bass on diets with various loadings of melamine and cyanuric acid adulterants

et al. 2015

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Section: Discussionsupporting

confidence: 93%

Section: Parametersmentioning

confidence: 93%

A study on growth, histopathology and oxidative stress in Asian sea bass on diets with various loadings of melamine and cyanuric acid adulterants

et al. 2015

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“…Neerman observed extensive liver necrosis and increased GPT activity in mice after injection with melamine dendrimer at 40 mg/kg of body weight (17). Liu et al (33) reported that feeding a diet containing 10000 mg of melamine/kg of diet increased ALP levels in Japanese sea bass, but the levels of GPT and GOT activity were not affected. One possible reason for this different response of liver function may be that the melamine supplemental levels were not sufficient to induce obvious injury to the liver in our study.…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Dietary Melamine to Laying Ducks: Biochemical and Histopathological Changes and Residue in Eggs

Gao

Yue

et al. 2010

J. Agric. Food Chem.

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Jinding laying ducks (n = 648) were subjected to one of six dietary treatments (0, 1, 5, 25, 50, or 100 mg of melamine/kg of diet) to investigate the toxicity of melamine and determine the melamine residue in eggs. Ducks were fed melamine-supplemented diets for 21 days followed by a 21 day withdrawal period. Dietary melamine had no adverse effects on laying performance. Renal lesions were correlated with increasing levels of dietary melamine. Melamine residue in eggs increased with dietary melamine during the first 21 days and reached the maximum content (1.35 mg/kg) in the 100 mg of melamine/kg of diet group. Melamine residue in eggs decreased rapidly during the withdrawal period. The depletion time for egg melamine residue increased with dietary melamine level. These results indicated that a dietary level of > or = 50 mg of melamine/kg of feed induces obvious renal injury. The residue level and withdrawal time for melamine clearance in eggs correlated with the dietary melamine level.

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“…Liu et al . () studied the acute toxicity of melamine on Japanese sea bass, Lateolabrax japonicus (Cuvier), and found that SGR was significantly lower when fed with 10 g melamine kg −1 feed, indicating that this fish is more sensitive to melamine than mammals. Janlek et al .…”

Section: Discussionmentioning

confidence: 99%

“…Liu et al . () reported that feeding 10 g of melamine kg −1 feed increased alkaline phosphatase (ALP) levels in Japanese sea bass; however, ALT and aspartate aminotransferase (AST) activity remained unaffected. The dosage of melamine used in the study may not be sufficient to induce obvious alterations in the liver.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of melamine, an adulterant in fish feeds: experimental assessment of its effects on tilapia

Phromkunthong

Nuntapong

Boonyaratpalin

et al. 2012

Journal of Fish Diseases

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Unscrupulous inclusion of melamine in fish feeds can be harmful to fish and may be hazardous to human health. An eight-week feeding trial examined the effects of melamine (inclusion levels; 5-30 g kg⁻¹ feed) on the growth performance, feed efficiency, histopathological changes and melamine residues in sex-reversed red tilapia, Oreochromis niloticus (L.) × O.mossambicus (Peters). Fish which received melamine-containing feeds grew less, utilized feeds less efficiently and performed poorly, besides exhibiting defects such as fin erosion, anorexia, sluggish swimming behaviour, paling/darkening of skin and low survival. Melamine concentration in the fish reflected its inclusion level in the feeds, and the content was higher in the viscera than in the fish fillet or whole fish. Histopathological alterations were evident in the kidney, liver and gills of fish subjected to melamine treatment - the severity of lesions corresponded to its dosage. Enlargement of renal tubules was observed in the kidney of fish fed with ≥10 g melamine kg⁻¹ feed, although, crystals were not deposited. Fish subjected to melamine insult had more prominent lesions in liver than in kidney. Toxic effects on the gills manifested as epithelial hyperplasia of the primary and secondary lamellae. The anomalies were severe at higher intake levels of melamine.

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ACUTE TOXICITY STUDY FOR MELAMINE ON JAPANESE SEA BASS(<I>LATEOLABRAX JAPONICUS</I>)

Cited by 9 publications

References 5 publications

A study on growth, histopathology and oxidative stress in Asian sea bass on diets with various loadings of melamine and cyanuric acid adulterants

A study on growth, histopathology and oxidative stress in Asian sea bass on diets with various loadings of melamine and cyanuric acid adulterants

Toxicity of Dietary Melamine to Laying Ducks: Biochemical and Histopathological Changes and Residue in Eggs

Toxicity of melamine, an adulterant in fish feeds: experimental assessment of its effects on tilapia

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