Acute toxicity, hepato-curative activity of extracts of a combination of plants on CCL4-induced hepatotoxicity in rats and antiradical activity

Youl, Estelle; Ballo, Mahamadou; Nadembega, Pascal; Lamien-Sanou, A.; Da, Filkpièrè Léonard; Haïdara, Mahamane; Sangaré, Modibo; Bah, S.; Ouédraogo, Moussa; Sanogo, Rokia

doi:10.30574/gscbps.2022.18.2.0077

Cited by 3 publications

(1 citation statement)

References 18 publications

(24 reference statements)

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“…8 In addition, pharmacological studies have shown the inhibitory effect of Ximenia americana on M. tuberculosis H37Rv and the hepato-curative effect of Terminalia macroptera. 9,10 The inhibitory activity of proinflammatory enzymes as well as the anti-inflammatory and antioxidant effects of both plants have been demonstrated. [11][12][13] Given that plant extracts contain several chemical compounds and would have interactions between them or with modern drugs.…”

Section: Introductionmentioning

confidence: 99%

Synergistic anti-inflammatory and analgesic activity of hydroethanolic extracts of Terminalia macroptera Guill. & Perr. and Ximenia americana L.

Ballo¹,

Diabaté²,

Dembélé³

et al. 2023

IJCAAP

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Inflammation is the reaction of the immune system to an external or internal aggression of the organism. The symptoms (redness, edema, heat and pain) are secondary to the increase in vascular permeability. The hydroethanolic extract of and has anti-inflammatory properties in vitro. The aim was to examine the anti-inflammatory and analgesic activities of extracts alone and in combination. The anti-inflammatory activity was studied using the carragenan-induced paw edema and the type of interactions between the two extracts was determined by the combination index and on the isobologram. Acetic acid-induced torsion and Haffner's tail clamp test were performed to evaluate the analgesic activity. At a dose of 500 mg/kg, a and extracts showed a percentage of inhibition of 57.02% and 56.53% respectively. The Median-Effective Dose of combination 2 (174.02 mg/kg) was better than that of combination 1 (186.03 mg/kg). The combination index and isobologram indicated a synergistic interaction between the constituents of the two combinations. The extract of , and the combination at the dose of 500 mg/kg reduced the number of twists by 46.42; 50.17 and 65.53% respectively. The central analgesic response of the combination was maximal (37.36 ± 8.15 seconds) 60 min after administration. The extracts alone showed anti-inflammatory activity and the combinations showed a synergy of effects. The combination showed peripheral and central analgesic effects.

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Section: Introductionmentioning

confidence: 99%

Synergistic anti-inflammatory and analgesic activity of hydroethanolic extracts of Terminalia macroptera Guill. & Perr. and Ximenia americana L.

Ballo¹,

Diabaté²,

Dembélé³

et al. 2023

IJCAAP

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Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin

Dossa,

Klotoé,

Dougnon

et al. 2024

Advances in Pharmacological and Pharmaceutical Sciences

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Hepatic diseases represent a public health problem. Among the approaches to their management is the use of traditional treatments based on the use of medicinal plants. In Benin, several recipes based on Cochlospermum tinctorium are used in the treatment of hepatitis without a real scientific basis. This study aimed to evaluate the hepatoprotective effects and acute oral toxicity of 10 of these recipes. The variables studied were the variety of C. tinctorium (wild form vs. cultivated form), the species associated with C. tinctorium (Combretum micranthum vs. Chromolaena odorata), and the proportion of C. tinctorium in the recipe (1; 4/5; 1/2). The hepatoprotective effect of these extracts at doses of 100, 200, and 400 mg/kg/bw was evaluated in Wistar rats subjected to hepatotoxicity induction through the administration of 5 g/kg of paracetamol. Acute oral toxicity was assessed following the OECD 423 protocol. The results revealed an absence of acute oral toxicity for the 10 recipes. The hepatoprotective tests conducted indicated that the hepatoprotective effect of C. tinctorium is dose dependent. The wild variety of C. tinctorium had a better hepatoprotective effect than the cultivated one. The association with C. micranthum enhances the hepatoprotective effect of C. tinctorium, unlike that with C. odorata. This study emphasizes that the combination of C. tinctorium with C. micranthum in the treatment of hepatitis is scientifically justified and it exhibits a dose‐dependent hepatoprotective effect.

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study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

N.H²,

Karim³

et al. 2022

IJPP

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Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 μg/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes

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Acute toxicity, hepato-curative activity of extracts of a combination of plants on CCL4-induced hepatotoxicity in rats and antiradical activity

Cited by 3 publications

References 18 publications

Synergistic anti-inflammatory and analgesic activity of hydroethanolic extracts of Terminalia macroptera Guill. & Perr. and Ximenia americana L.

Synergistic anti-inflammatory and analgesic activity of hydroethanolic extracts of Terminalia macroptera Guill. & Perr. and Ximenia americana L.

Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin

study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

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