Acute toxicity and esterase response to carbaryl exposure in two different populations of amphipods Hyalella curvispina

Anguiano, Olga L.; Vacca, Melina; Montagna, Marcela C.; Venturino, Andrés; Ferrari, Alejandro

doi:10.1016/j.aquatox.2017.04.013

Cited by 14 publications

(3 citation statements)

References 38 publications

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“…An integrative view on the situation in the two investigated streams that explains the entirety of our data, however, requires the proposal for microevolutionary effects that have led to the selection of unspecifically tolerant phenotypes in the river Erms connected to the 3-stage-WWTP. The selection for tolerance in amphipods has already been shown by Anguiano et al [71] for Hyalella curvispina, and has also been reported for other freshwater crustaceans [72,73]. An interaction of freshwater pollution and the origin of gammarid populations defining the stress response of transplanted G. fossarum individuals to their habitat has been found by Schill and Köhler [74].…”

Section: Differences Between the Two Rivers And Sites-influence Of Th...supporting

confidence: 52%

Heat Tolerance of Gammarus fossarum (Crustacea, Amphipoda) Is Influenced by the Level of Stress Associated with Reproduction and the Water Quality of Their Habitat

Peschke,

Sawallich,

Köhler

et al. 2024

Pollutants

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To elucidate how rising temperatures influence native amphipods, and how the expansion of wastewater treatment plants (WWTPs) with a fourth purification stage can alter temperature-related effects, studies were conducted in anthropogenically influenced rivers in Southwest Germany. Gammarids were sampled up- and downstream of two WWTPs, and exposed to elevated temperatures in the laboratory. Gammarids separated from precopula pairs were more sensitive to exposure-related stress and to a temperature increase than animals that were not in the reproductive phase. Furthermore, females were significantly more sensitive than males. Adult gammarids sampled individually at the WWTP with three purification stages showed a similar tolerance to elevated temperature at the up- and downstream site. In contrast, mortality following heat stress was substantially lower in animals sampled downstream of the WWTP with four treatment stages than in those sampled at the upstream site. We assume that the increased sensitivity of artificially separated precopula pairings reflect the situation under high hydraulic stress after heavy rainfall. Our results further illustrate the importance of WWTP upgrades in the context of climate change: gammarids sampled downstream the upgraded fourth-stage WWTP were likely exposed to lower levels of micropollutants, and thus may have allocated energy from detoxification to heat stress responses.

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Section: Differences Between the Two Rivers And Sites-influence Of Th...supporting

confidence: 52%

Heat Tolerance of Gammarus fossarum (Crustacea, Amphipoda) Is Influenced by the Level of Stress Associated with Reproduction and the Water Quality of Their Habitat

Peschke,

Sawallich,

Köhler

et al. 2024

Pollutants

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“…Carbaryl at high concentrations selectively affected the process of mitochondrial respiration in rat mitochondria (Moreno et al, 2007). Hyalella curvispina exposed to carbaryl exhibited decrease in the carboxylesterase (CabE) activity (Anguiano et al, 2017). Varying concentrations of carbaryl demonstrated behavioral changes, histological alterations, and DNA damage in lizards (Freitas et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Saquib

Siddiqui

Ansari

et al. 2021

J of Applied Toxicology

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Pesticides have adverse effects on the cellular functionality, which may trigger myriad of health consequences. However, pesticides‐mediated toxicity in the endothelial cells (ECs) is still elusive. Hence, in this study, we have used human umbilical vein endothelial cells (HUVECs) as a model to quantify the cytotoxicity and genotoxicity of four pesticides (methomyl, carbaryl, metalaxyl, and pendimethalin). In the MTT assay, HUVECs exposed to methomyl, carbaryl, metalaxyl, and pendimethalin demonstrated significant proliferation inhibition only at higher concentrations (500 and 1000 μM). Likewise, neutral red uptake (NRU) assay also showed proliferation inhibition of HUVECs at 500 and 1000 μM by the four pesticides, confirming lysosomal fragility. HUVECs exposed to the four pesticides significantly increased the level of intracellular reactive oxygen species (ROS). Comet assay and flow cytometric data exhibited DNA damage and apoptotic cell death in HUVECs after 24 h of exposure with methomyl, metalaxyl, carbaryl, and pendimethalin. This is a first study on HUVECs signifying the cytotoxic–genotoxic and apoptotic potential of carbamate insecticides (methomyl and carbaryl), fungicide (metalaxyl), and herbicide (pendimethalin). Overall, these pesticides may affect ECs functions and angiogenesis; nonetheless, mechanistic studies are warranted from the perspective of vascular biology using in vivo test models.

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“…Moreover, we clearly give evidence for the fast decrease of carbaryl toxicity upon irradiation on the three solid surfaces from the early stages of the reaction. As clearly shown, carbaryl itself presents a relatively high toxicity since a total inhibition of AchE activity was obtained at the initial time [46][47][48]. Moreover, upon sunlight irradiation, the enzyme inhibition drastically decreases, more particularly within the first stages of irradiation.…”

Section: Discussionmentioning

confidence: 94%

Carbaryl Photochemical Degradation on Soil Model Surfaces

et al. 2019

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The phototransformation of carbaryl was investigated upon solar light exposure on three surfaces, silica, kaolin and sand, as soil models. By excitation with a Suntest set up at the surface of the three solid supports, the degradation of carbaryl followed first-order kinetics with a rate constant of 0.10 h−1. By using the Kubelka Munk model, the quantum yield disappearance at the surface of kaolin was evaluated to 2.4 × 10−3. Such a value is roughly one order of magnitude higher than that obtained in aqueous solutions. The results indicated that the particle size and the specific surface area of the various models have significant effects. The photo-oxidative properties as well as the byproduct elucidation by liquid chromatography combined with diode arrays (LC-DAD) and liquid chromatography coupled mass spectrometry (LC-MS) analyses allowed us to propose the degradation mechanism pathways. The main products were 1-naphtol and 2-hydroxy-1,4-naphthoquinone, which arise from a photo-oxidation process together with products from photo-Fries, photo-ejection and methyl carbamate hydrolysis. The toxicity tests clearly showed a significant decrease of the toxicity in the early stages of the irradiation. This clearly shows that the generated products are less toxic than the parent compound.

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Acute toxicity and esterase response to carbaryl exposure in two different populations of amphipods Hyalella curvispina

Cited by 14 publications

References 38 publications

Heat Tolerance of Gammarus fossarum (Crustacea, Amphipoda) Is Influenced by the Level of Stress Associated with Reproduction and the Water Quality of Their Habitat

Heat Tolerance of Gammarus fossarum (Crustacea, Amphipoda) Is Influenced by the Level of Stress Associated with Reproduction and the Water Quality of Their Habitat

Cytotoxicity and genotoxicity of methomyl, carbaryl, metalaxyl, and pendimethalin in human umbilical vein endothelial cells

Carbaryl Photochemical Degradation on Soil Model Surfaces

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