Acute toxication of deltamethrin results in activation of iNOS, 8-OHdG and up-regulation of caspase 3, iNOS gene expression in common carp ( Cyprinus carpio L.)

Arslan, Harun; Altun, Serdar; Özdemir, Selçuk

doi:10.1016/j.aquatox.2017.03.014

Cited by 68 publications

(28 citation statements)

References 61 publications

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“…Eight‐OHdG is a sensitive biomarker of oxidative DNA damage caused by ROS. A study of acute toxication of deltamethrin in common carp showed a significant increase of 8‐OHdG in gill, liver, and brain, 8 which is in accordance with our results. Therefore, deltamethrin could lead to DNA damage in hemocytes of P. clarkii at sublethal concentrations and probably caused by oxidative stress.…”

Section: Discussionsupporting

confidence: 92%

“…All these evidences above indicate the potential threat of deltamethrin on P. clarkii during farming. In addition, numerous studies showed that deltamethrin could induce oxidative stress, immune suppression, behavioral disorder, and tissue damage in aquatic organisms even under sublethal concentrations 8,21,34 . As a consequence, we investigated the genotoxicity, immunotoxicity, and neurotoxicity of deltamethrin on P. clarkii with several typical parameters by sublethal exposure for the first time.…”

Section: Discussionmentioning

confidence: 99%

“…A large number of studies demonstrated that deltamethrin is highly toxic to diverse aquatic organisms. However, most of them are focused on fish or microcrustaceans, and few have been reported regarding commercial macrocrustacean species 4,8,9 …”

Section: Introductionmentioning

confidence: 99%

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DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii

Hong

Huang

Yan

et al. 2020

Environmental Toxicology

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Pyrethroid pesticides are applied to both agricultural and aquacultural industries for pest control. However, information of their impact on the commercial important freshwater crayfish, Procambarus clarkii is scarce. Therefore, the present study aimed to characterize to effects of a commonly used pyrethroid pesticide, deltamethrin on DNA damage, immune response, and neurotoxicity in P. clarkii. Animals were exposed to 7, 14, and 28 ng/L of deltamethrin, which correspond to 1/8, 1/4, and 1/2 of the LC 50 (96 hours) of this pyrethroid to P. clarkii. Significant increase of olive tail moment (OTM) and 8-hydroxy-2 0-deoxyguanosine (8-OHdG) was found after deltamethrin exposure in a dose-dependent way. Total hemocyte counts (THC) and activities of immune-related enzymes including acid phosphatase (ACP), lysozyme (LZM), and phenoloxidase (PO) were all decreased and significantly lower than control at concentration of 28 ng/L after 96 hours exposure. Acetylcholinesterase (AChE) activity, an indicator of neurotoxic effect was investigated and it was decreased significantly in muscles at 14 and 28 ng/L after 24 hours exposure. The level of intracellular reactive oxygen species (ROS) in hemocytes was also measured and the significant increase of ROS was found at 14 and 28 ng/L concentrations. The results revealed that deltamethrin induced DNA damage, immunotoxicity, and neurotoxicity in P. clarkii by excessive generation of ROS. Because of the dose-dependent responses of all parameters under exposure of deltamethrin at environmentally realistic concentrations, these parameters could be used as sensitive biomarkers for risk assessment of deltamethrin in aquaculture area.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii

Hong

Huang

Yan

et al. 2020

Environmental Toxicology

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“…In addition, 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is produced as a result of oxidative attack to DNA or RNA, is widely used as a biomarker of DNA damage and oxidative stress [ 21 ]. Activation of 8-OHdG has been shown to be increased in fish brains exposed to toxic chemicals [ 22 , 23 ]. Moreover, tumor necrosis factor-alpha (TNF-α) is an inflammatory mediator [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Imidacloprid exposure cause the histopathological changes, activation of TNF-α, iNOS, 8-OHdG biomarkers, and alteration of caspase 3, iNOS, CYP1A, MT1 gene expression levels in common carp (Cyprinus carpio L.)

2018

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“…The elevated IL-6 and TNF-α levels observed could thus, be a result of these redox-sensitive factors, activated by combined As and DM induced oxidative stress. Several studies have shown that either toxicant can induce the expression of proinflammatory cytokines [7,47]. 8-NO 2 -Gua is a product of the interaction of the highly reactive peroxynitrite, formed when nitric oxide synthase reacts with superoxide, and guanine, during inflammation [48].…”

Section: Discussionmentioning

confidence: 99%

Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

Kayode¹,

Arinola²,

Adesola³

et al. 2019

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This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg -1 ), catechin only (CT) at 40mg kg -1 , As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg -1 (1/20 th LD 50 ), As+DM-CT 40 treated as As+DM in addition to oral administration of CT at 40mg kg -1 while the last group, As+DM-CT 80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg -1 . The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.

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Acute toxication of deltamethrin results in activation of iNOS, 8-OHdG and up-regulation of caspase 3, iNOS gene expression in common carp ( Cyprinus carpio L.)

Cited by 68 publications

References 61 publications

DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii

DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii

Imidacloprid exposure cause the histopathological changes, activation of TNF-α, iNOS, 8-OHdG biomarkers, and alteration of caspase 3, iNOS, CYP1A, MT1 gene expression levels in common carp (Cyprinus carpio L.)

Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

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