Acute Squamous Cell Carcinoma Arising within a Recent Burn Scar in a 14-Year-Old Boy

Love, Robert L.; Breidahl, A.F.

doi:10.1097/00006534-200010000-00017

Cited by 37 publications

(29 citation statements)

References 8 publications

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“…Approximately 2% of the burn scars undergo malignant transformation to SCC, while 0.3%-0.5% to BCC. 1,7 In our study, all of our cases had a malignant transformation to SCC. No malignant melanoma or BCC was observed.…”

Section: Discussionmentioning

confidence: 47%

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Squamous Cell Carcinoma Developing on Burn Scar

Gül

Kılıç

2006

Annals of Plastic Surgery

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Section: Discussionmentioning

confidence: 47%

“…1,2 In the etiopathogenesis, several factors such as solar factors, arsenic, thermal factors, chronic radiation, viral factors, and immunosuppression are responsible. 2,3 SCC can also develop on chronic scars and on persistent benign dermatosis.…”

mentioning

confidence: 99%

Squamous Cell Carcinoma Developing on Burn Scar

Gül

Kılıç

2006

Annals of Plastic Surgery

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“…Indeed, the most acute cases of Marjolin's ulcer have arisen 6 weeks post-burn [22,23]. Our case report is unique to the literature because our patient had a welldifferentiated squamous cell carcinoma that developed within 4 weeks of a traumatic burn.…”

Section: Discussionmentioning

confidence: 74%

Development of Marjolin’s ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping

2010

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Marjolin's ulcer defines the occurrence of malignancy, usually squamous cell carcinoma, in the setting of a post-traumatic scar often following thermal injury. The latency period from the time of injury to the onset of malignant transformation averages 30 years with the earliest documented incidence occurring 6 weeks after injury. In addition, the occurrence of multiple primary malignancies is a rare event. To our knowledge, we report the first case in the literature of a well-differentiated squamous cell carcinoma developing within 1 month of thermal injury to an elderly patient's right index finger with an incidental synchronous primary lung moderately differentiated squamous cell carcinoma that was morphologically and genetically different as confirmed by allelotyping. There is scant precedent literature on acute Marjolin's ulcers, and the most acute cases have arisen 6 weeks post-burn. There is also little published literature on the incidence of multiple primary malignancies. The quoted incidence of this event is <1%. Clinicians should be aware of the possibility of malignant transformation at the site of prior thermal injury. Biopsy remains the gold standard for diagnosis for Marjolin's ulcer. MRI is the most important diagnostic imaging tool because it will demonstrate the margins and extent of the lesion. Due to the aggressive nature of Marjolin's ulcer, treatment is usually surgical and dependent upon grading. When multiple lesions are detected after staging of a presumed neoplasm, the possibility of multiple primary maligancies should be considered. Allelotyping is a process that can be utilized to determine if multiple masses are related.

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“…21 Of all of the predisposing, chronic conditions and carcinogenic agents reported and studied, cutaneous trauma has very rarely been described as a catalytic stimulus for acute SCC emergence. [22][23][24] The ''skin pathergy reaction'' and the ''isomorphic response of Koebner'' are established terms that describe the emergence of pre-existing nonmalignant dermatoses in nearby sites of trauma. Heinrich Koebner (1838Koebner ( -1904 first described the phenomenon that he observed in patients who developed psoriasis at sites of trauma such as excoriations, horse bites, and tattoos.…”

Section: Discussionmentioning

confidence: 99%