Eruptive postoperative squamous cell carcinomas exhibiting a pathergy-like reaction around surgical wound sites

Bangash, Suleman; Green, W. Harris; Dolson, David J.; Cognetta, Armand B.

doi:10.1016/j.jaad.2009.01.037

Cited by 13 publications

(12 citation statements)

References 39 publications

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“…2 These areas of normal-appearing epithelium may evolve into carcinoma given the stimulus of trauma and subsequent cytokine and growth factor release, high mitotic activity, and rapid proliferation associated with the epidermal healing process. With respect to the skin, it is postulated that clonal expansion of genotypically altered yet phenotypically and histologically normal keratinocytes will give rise to sheets of mutagenically altered epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Such areas of altered epithelium have been detected at sizes greater than 7 cm in diameter within the mucosa of the head and neck. 2 These areas of normal-appearing epithelium may evolve into carcinoma given the stimulus of trauma and subsequent cytokine and growth factor release, high mitotic activity, and rapid proliferation associated with the epidermal healing process. Conceptually, this may explain why SCCs and KAs arise at sites of trauma.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Squamous Cell Carcinomas and Eruptive Keratoacanthomas in an Arc Welder

Wolfe

Green

Cognetta

et al. 2013

Dermatologic Surgery

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The authors have indicated no significant interest with commercial supporters. W e report an arc welder who developed 51 squamous cell carcinomas (SCCs) on the dorsal upper extremities after 10 years of unprotected arc welding. SCCs began to appear 27 years after he started welding. Mohs surgery and acitretin were necessary to control his disease. Case ReportA 52-year-old Caucasian man, Fitzpatrick skin type III, was referred to our clinic in 2007 for three eruptive SCCs adjacent to two recent surgical sites in which tumor-free margins were confirmed. Past history was negative for carcinogenic exposure and immunosuppression. As a child and teenager, he participated in outdoor activities on the weekends and summers and had occasional sunburns. Other sources of significant sun exposure were not identified. He had received multiple tattoos on his upper extremities beginning approximately 30 years before his initial visit. Occupational history revealed that he had worked as a metal arc welder indoors in a boiler plant beginning 27 years before the eruption of his first SCC. He welded approximately 4 hours per day for 10 years and reported not wearing protective clothing. Typical work attire included a sleeveless shirt, jeans, and leather boots. He reported multiple small burns from molten metal spatter and feeling "sunburned" on his upper extremities after welding. Initial examination revealed multiple small circular scars and ultraviolet radiation (UVR) damage, which consisted of spotty depigmentation, hyperpigmentation, and mild erythema of the exposed face, neck, and upper extremities. A small number of fine actinic keratoses were noted on the upper extremities. Multiple multicolored and black tattoos were noted on his dorsal upper extremities. Mohs surgery was used to treat the three SCCs and two additional SCCs found on initial examination (Figure 1), with suspected metal fragments found intraoperatively. Acitretin was started at his initial visit in 2007. He continued to develop multiple keratoacanthomas (KAs) adjacent to surgical sites and SCCs at distant sites, with a halt of tumor formation in 2009. Acitretin was discontinued in 2010 after a 1-year tumor-free period. In 2012, tattoo application over preexisting tattoos (Figure 2) resulted in the formation of new eruptive SCCs and KAs within these tattoos (Figure 3). Of 54 total lifetime skin cancers, all were SCCs-51 on the dorsal upper extremities and three on the face. The location and associated factors for the 51 SCCs are depicted in Figure 4. All sites were treated using Mohs surgery. Examination for occult malignancy was negative.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Multiple Squamous Cell Carcinomas and Eruptive Keratoacanthomas in an Arc Welder

Wolfe

Green

Cognetta

et al. 2013

Dermatologic Surgery

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“…The dermatopathology findings were not consistent with keratoacanthomas. The aetiology of these eruptive CSCCs was unclear but was probably related to a combination of field cancerization because of her history of extensive phototherapy [narrowband ultraviolet (UV)B and psoralen UVA] and her treatment with etanercept and methotrexate for her psoriasis …”

Section: Reportmentioning

confidence: 99%

“…The aetiology of these eruptive CSCCs was unclear but was probably related to a combination of field cancerization because of her history of extensive phototherapy [narrowband ultraviolet (UV)B and psoralen UVA] and her treatment with etanercept and methotrexate for her psoriasis. 1 The patient's age, her poorly controlled psoriasis and the presence of multiple tumours below the knee and recent cellulitis in the same leg increased the likelihood of healing complications and precluded surgical treatment. The patient had a strong preference against extensive surgical procedures.…”

Section: Reportmentioning

confidence: 99%

Eruptive cutaneous squamous cell carcinoma and psoriasis: response to cetuximab

et al. 2014

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Cutaneous squamous cell carcinomas (CSCCs) comprise 20-30% of nonmelanoma skin cancers (NMSCs), and continue to increase in incidence. We report a case of a patient with severe psoriasis who had recurrent and eruptive CSCCs on her leg, which were successfully treated with cetuximab and radiotherapy. The patient had successful long-term clearance of her skin tumours, with the additional finding of resolution of psoriasis while on cetuximab therapy.

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“…The amount of percutaneous absorption depends on many factors, for example the molecular structure/potency of the TCS. 1 We examined the effect of potent TCSs on adrenal gland cortisol production in 57 patients (mean age, 39 years; 43.9% men) with severe atopic dermatitis (AD) during and after treatment in hospital. On the first day of admission (day 1), patients were treated with 20 to 30 g of TCSs twice daily (n ¼ 31; class 1, 0.05% clobetasol propionate; and n ¼ 26; class 3, 0.1% betamethasone valerate).…”

Section: Research Lettermentioning

confidence: 99%

“Eruptive postoperative squamous cell carcinomas” or “Hypertrophic lichen planus–like reactions combined with infundibulocystic hyperplasia”?

Toll¹,

Salgado

Espinet

2010

Journal of the American Academy of Dermatology

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Eruptive postoperative squamous cell carcinomas exhibiting a pathergy-like reaction around surgical wound sites

Cited by 13 publications

References 39 publications

Multiple Squamous Cell Carcinomas and Eruptive Keratoacanthomas in an Arc Welder

Multiple Squamous Cell Carcinomas and Eruptive Keratoacanthomas in an Arc Welder

Eruptive cutaneous squamous cell carcinoma and psoriasis: response to cetuximab

“Eruptive postoperative squamous cell carcinomas” or “Hypertrophic lichen planus–like reactions combined with infundibulocystic hyperplasia”?

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