“…In this setting, cetuximab, a chimeric human monoclonal antibody binding competitively and with high affinity to the EGFR, prevents receptor stimulation by endogenous ligands and inhibits proliferation, enhances apoptosis, and reduces angiogenesis, invasiveness, and metastatic spreading in target tissues. By analogy with advanced head and neck SCC where it proved efficient alone or associated with radiotherapy and/or chemotherapy [4,5,6,7], a number of case reports, small series reports [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26], and scarce clinical trials or larger series [27,28,29] recently suggested that cetuximab may help control metastatic or locally advanced, unresectable cSCC, either alone or in combination with other therapies including systemic chemotherapy and/or radiotherapy. In order to add further information regarding its interest in advanced cSCC, the efficacy and safety of cetuximab alone or combined with chemotherapy in patients with locally advanced and metastatic cSCC treated at our institution were retrospectively analyzed.…”