Acute Renal Failure in the Neonate

Jain, Reena

doi:10.1016/s0031-3955(16)33469-1

Cited by 11 publications

(4 citation statements)

References 59 publications

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“…It is as well essentially distributed into a physiological space equiv alent to the extracellular fluid volume [14], Gentamicin disposition may be affected by impaired renal function or an altered volume of distribution. Neonatal factors which can impair renal function include: perinatal hypoxia [9], hypoxemia [10], severe respiratory distress syndrome [11], concomitant medications associated with nephrotoxicity, and congenital renal disease [12], The volume of distribution may be decreased by dehydration second ary to diuretic therapy by or increased by overhydration [13]. It is not known which if any of these factors affected gentamicin disposition in the neonates we studied.…”

Section: Discussionmentioning

confidence: 99%

High Gentamicin Trough Concentrations in Neonates of Less than 28 Weeks Gestational Age

Zarowitz¹,

Wynn²,

Buckwald³

et al. 1982

Dev Pharmacol Ther

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77 newborns, ranging from 25.5 to 43 weeks gestational age (GA) and receiving gentamicin, were studied prospectively over 4 months. Peak and trough serum concentrations were obtained on days 1, 3, and 5 of therapy. Gentamicin, 2.5 mg/kg/dose, was given at intervals according to GA. 63% of newborns of < 28 weeks on doses of gentamicin of 2.5 mg/kg every 24 h (q24h), 75% of < 28 weeks on gentamicin q18h, 90% of newborns of 23-34 weeks (on q18h), and 82 % of those of > 34 weeks GA (on q12h) had serum gentamicin trough concentrations ≤ 2.0 pg/ml on day 1. By day 3, 5/5 newborns of < 28 weeks (q18h) had trough concentrations > 2.0 μg/ml, whereas only 20% of those on the q24h regimen had high trough concentrations (p < 0.05). Possible risk factors associated with altered gentamicin disposition in neonates are discussed.

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Section: Discussionmentioning

confidence: 99%

High Gentamicin Trough Concentrations in Neonates of Less than 28 Weeks Gestational Age

Zarowitz¹,

Wynn²,

Buckwald³

et al. 1982

Dev Pharmacol Ther

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“…Secara fisiologis suplai darah ke daerah juksta medular lebih banyak dibandingkan korteks, padahal volume korteks 3 kali lebih besar dibandingkan medula dan secara mikroskopis membran basal glomerolus bayi tipis dan belum berkembang sempurna. 13 Kondisi yang tidak menguntungkan tersebut menyebabkan fungsi ginjal pada bayi lebih mudah terganggu terutama pada keadaan stres yang dapat mempengaruhi proses metabolisme dan homeostasis. 20 Gangguan fungsi ginjal pada tahap dini bersifat ringan dengan gejala azotemia prerenal yaitu kenaikan kadar kreatinin dan ureum serum akibat hipoperfusi di daerah korteks.…”

Section: Diskusiunclassified

“…Hipoksia yang berlangsung lama akibat asfiksia berat akan menyebabkan iskemia ginjal sehingga dapat berlanjut menjadi GGA intrinsik. [12][13][14][15] Carlowicz dan Adelman 7 pada penelitian prospektif terhadap 33 bayi alam dua dekade terakhir ini teknik monitor bayi ante dan intra partum sudah berkembang pesat, namun risiko asfiksia pada bayi baru lahir tetap menjadi masalah.…”

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Hubungan Asfiksia Neonatorum dengan Gangguan Fungsi Ginjal pada Bayi Baru Lahir

Umboh¹

2016

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Asfiksia neonatorum merupakan problem kesehatan pada bayi baru lahir yang dapat menyebabkan gagal ginjal akut jika tidak ditangani dengan baik. Tujuan: untuk mengetahui hubungan antara derajat asfiksia neonatorum dengan derajat gangguan fungsi ginjal Metoda: penelitian analitik observasional pada bayi baru lahir di bangsal Neonatologi Bagian IKA/RSUP Manado antara bulan Agustus 1997-Februari 1998 yang memenuhi kriteria dilakukan pengukuran kadar ureum dan kreatinin serum serta penentuan laju filtrasi glomerulus (LFG). Data dianalisis dengan uji Anova dan Chi-Square. Hasil: di antara 129 bayi baru lahir yang memenuhi kriteria terdiri dari 49 bayi sehat, 50 asfiksia ringan-sedang, dan 30 asfiksia berat. Terdapat perbedaan bermakna kadar serum ureum dan kreatinin serta LFG antara kelompok bayi sehat dengan asfiksia berat dan antara kelompok asfiksia ringan-sedang dengan asfiksia berat (p<0,01). Lima dari 30 kasus asfiksia berat mengalami gagal ginjal akut dan terdapat hubungan bermakna antara derajat asfiksia dengan derajat gangguan fungsi ginjal (p<0,01). Kesimpulan: terdapat perbedaan antara kadar ureum dan kreatinin serum serta LFG antara bayi asfiksia berat dengan bayi sehat dan asfiksia ringan-sedang. Terdapat pula hubungan antara derajat asfiksia dengan derajat gangguan fungsi ginjal.Kata kunci: bayi baru lahir -asfiksia -gangguan fungsi ginjal Sari

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“…In our own unit between 1980-1984 12.4% (11 of 89) of all early neonatal deaths in infants with a birth weight less than 1000 g were associated with cardiac arrhythmias and hyperkalemia. Sodium polystyrene sulfonate (SPS) (Kayexalate TM) or calcium polystyrene sulfonate (CPS) dissolved in water, 10% dextrose in water or sorbitol currently are recommended in the treatment of hyperkalemia (serum potassium > 7.0 mmol/1) either by the oral or the rectal route [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Complications following oral administration of exchange resins in extremely low-birth-weight infants

Ohlsson

Hosking

1987

Eur J Pediatr

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Complications of the oral use of sodium polystyrene sulfonate and calcium polystyrene sulfonate are reported in five extremely low-birth-weight infants in which exchange resins were used to treat hyperkalemia. Radio opaque masses outlining the stomach were seen in all infants and could be palpated in the left upper quadrant of the abdomen. In two infants, at autopsy the palpable mass could be identified as a solid chalk-like concretion outlining the stomach. X-ray diffraction studies identified the material as Brushite. Administration of exchange resins by the gastric route should be avoided in the treatment of hyperkalemia in critically sick, extremely low-birth-weight infants.

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Acute Renal Failure in the Neonate

Cited by 11 publications

References 59 publications

High Gentamicin Trough Concentrations in Neonates of Less than 28 Weeks Gestational Age

High Gentamicin Trough Concentrations in Neonates of Less than 28 Weeks Gestational Age

Hubungan Asfiksia Neonatorum dengan Gangguan Fungsi Ginjal pada Bayi Baru Lahir

Complications following oral administration of exchange resins in extremely low-birth-weight infants

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