Acute Renal Failure Associated with Dermatomyositis and Colon Cancer

Park, Sung Kwang; Cho, Kwang Ho; Kang, Sung Kyew

doi:10.1159/000185961

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…It was previously considered that rhabdomyolysis leading to acute renal failure was uncommon in PM and DM because the rate and degree of myolysis could be lower than those of myotoxic drug-related necrotizing myopathy [11]. However, myoglobinuria-induced acute tubular necrosis caused by PM or DM has been reported in the literature, especially in patients with DM [12][13][14][15][16][17][18][19][20]. e other type of renal damage related to PM or DM is chronic glomerulonephritis, which is presumed to be immune-mediated, and exhibits a variety of histologic features.…”

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Tsubouchi

Mizuuchi

Yamamoto

et al. 2022

Case Reports in Rheumatology

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Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association.

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Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Tsubouchi

Mizuuchi

Yamamoto

et al. 2022

Case Reports in Rheumatology

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“…There have been case reports of dermatomyositis with myoglobinuria or renal failure with variable treatment outcomes both with and without malignancy [3,6,[16][17][18][19][20]. Renal involvement in patients with polymyositis (PM)/dermatomyositis (DM) was previously thought to be uncommon, but two main types of renal lesion have been described [20].…”

Section: Myoglobinuriamentioning

confidence: 99%

Untitled

2021

ARAR

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Rhabdomyolysis and myoglobinuria are a rare complication of dermatomyositis. Rhabdomyolysis has a wide range of presentations, from asymptomatic to life-threatening. The most dramatic presentation can result in acute renal failure, electrolyte imbalances, and/or disseminated intravascular coagulation (DIC). Recognition of this fact has important therapeutic implications as patients require immunotherapy in addition to the symptomatic treatment for renal failure. Here we present a 30 year old male banker presented with progressive muscle pain and weakness for 10 days and high colored urine for 3 days. Laboratory findings suggested rhabdomyolysis. A diagnosis of dermatomyositis was based upon the proximal muscle weakness on both upper and lower limbs, skin lesion over face and upper trunk, elevated muscle enzyme levels, muscle biopsy and skin biopsy findings. The patient was managed with high dose prednisolone and steroid sparing agent. His muscle power did improve slightly. In our view, this is an interesting case in that dermatomyositis cause fulminant rhabdomyolysis without causing myoglobinuric acute kidney injury (AKI) due to direct toxic effect of myoglobulin on renal tubule.

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“…The DM in 1 case was associated with cancer of an unknown primary site, possibly the colon, and DM involuted after treatment with high dose steroid and methotrexate [ 2 ]. The other case presented with acute renal failure associated DM and colon cancer [ 3 ]. However, this article did not show a relationship between cancer and DM.…”

mentioning

confidence: 99%