Paraneoplastic dermatomyositis presenting myopathy combined with synchronous cervical and sigmoid colon cancer

Chung, Joo-Seop; So, Min Wook; Kim, Seong‐Geun

doi:10.3904/kjim.2014.333

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…About a third of patients diagnosed with DM are diagnosed with cancer during its clinical course [6], with adenocarcinomas of the lung, stomach, pancreas, colon, and pelvis being most common [2,4,6,10]. The malignancy is most likely diagnosed simultaneously with or shortly after the diagnosis of myopathy has been made [10][11][12]. In our case, investigations revealed cecal adenocarcinoma which we believe to be the cause of her paraneoplastic DM as well as her MAHA.…”

Section: Discussionmentioning

confidence: 73%

“…The antibodies which indicated a higher risk of malignancy were: transcription intermediary factor 1γ (TIF-1γ) [5], and nuclear matrix protein NXP-2 [3,5,8,9]. About a third of patients diagnosed with DM are diagnosed with cancer during its clinical course [6], with adenocarcinomas of the lung, stomach, pancreas, colon, and pelvis being most common [2,4,6,10]. The malignancy is most likely diagnosed simultaneously with or shortly after the diagnosis of myopathy has been made [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…The first line of therapy in DM is systemic glucocorticoids; hence, it was started for our patient. Methotrexate or azathioprine is among other possible therapeutic options [2,[8][9][10][11] with consequent intravenous immunoglobulin in refractory disease [2,10]. This regimen is not easily implemented in the presence of malignancy [3] as it is based on immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

“…This regimen is not easily implemented in the presence of malignancy [3] as it is based on immunosuppression. It is assumed that, because DM is paraneoplastic in origin, antitumoral treatment would also help treat the myositis [3,10,11] and a survey reported an improvement in about 40% of patients with surgically resected tumors [11]. Nonetheless, malignancy remains a factor affiliated with poor prognosis in myositis [12] with about 30% of patients remaining severely disabled despite treatment [11].…”

Section: Discussionmentioning

confidence: 99%

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Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome

2021

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Dermatomyositis (DM) is a rheumatological disorder characterized by proximal myositis and distinctive dermatological manifestations. It can be an isolated clinical syndrome or, in rarer cases, can be the initial presentation for an underlying malignancy as a part of a paraneoplastic syndrome. In this case report, we describe a case of a 51-year-old lady who presented with proximal myopathy, typical DM skin rash, dysphagia, and markedly elevated creatine kinase. She was diagnosed with a seronegative DM and her malignancy screening revealed a mass in the ascending colon. During her hospital course, she also developed microangiopathic hemolytic anemia, another paraneoplastic disorder typically associated with late stages of malignancy, manifested as hemolytic anemia, thrombocytopenia, and low fibrinogen. The patient received intravenous corticosteroids and underwent tumor resection with following resolution of her both rheumatological and hematological manifestation. Unfortunately, due to her general poor health, she developed sepsis and died in the hospital.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Colon Cancer: An Unusual Presentation with a Paraneoplastic Syndrome

2021

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“…Our patient had SCC of cervix which is the second most common cancer among women in India 12. Despite its higher prevalence, paraneoplastic dermatological manifestations associated with cervical cancer is rare 13–19. A nationwide study done among 1012 DM patients in Taiwan revealed only 3 patients having cervical cancer 11.…”

Section: Discussionmentioning

confidence: 99%

Dermatomyositis presenting as heart failure revealed a concealed cervical malignancy: an infrequent clinical nexus

et al. 2020

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Dermatomyositis (DM) belongs to the spectrum of inflammatory myopathies which are a heterogeneous group of acquired disorders in which dysregulated immune system is thought to play a major pathologic role. Patients with DM generally present with characteristic skin manifestations with or without muscle weakness and pain. Although subclinical myocardial involvement in DM is well reported in literature, heart failure (HF) as its principal manifestation is extremely rare. Recognition of DM, a known paraneoplastic syndrome, should prompt clinicians to search for underlying malignancy. While gynaecological malignancies are common in association with DM, cervical cancer has rarely been heard of as an aetiology of paraneoplastic DM. We are reporting a case of DM in a postmenopausal woman presenting with advanced decompensated congestive HF with hidden squamous cell carcinoma of cervix.

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