Acute phase response in cattle infected with Anaplasma marginale

Nazifi, Saeed; Razavi, S. M.; Kaviani, F.; Rakhshandehroo, Ehsan

doi:10.1016/j.vetmic.2011.08.024

Cited by 20 publications

(13 citation statements)

References 15 publications

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“…IgA and IgG were elevated (p < 0.05), which may have been the result of the constant antigenic stimulation that T. vivax causes, due to continuous changes in the expression of surface-variant glycoproteins (Lalor et al, 1984) Ceruloplasmin, a copper carrier protein that acts toward oxidation of ferrous ions and has antioxidant and anti-inflammatory activity (Murata et al, 2004), was significantly reduced in the NIF group, consistent with previous observations among sheep experimentally infected with T. vivax (Almeida et al, 2012). Cattle infected with Anaplasma marginale showed higher levels of ceruloplasmin during the acute phase (Nazifi et al, 2012), thus allowing differentiation between these two diseases. This reduction, associated with the release of ferrous iron through hemolysis, may promote greater entry of iron ions to cells (Attieh et al, 1999;Ke et al, 2006).…”

Section: Discussionsupporting

confidence: 87%

Acute-phase protein behavior in dairy cattle herd naturally infected with Trypanosoma vivax

Sampaio

Fidélis

Marques

et al. 2015

Veterinary Parasitology

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Section: Discussionsupporting

confidence: 87%

Acute-phase protein behavior in dairy cattle herd naturally infected with Trypanosoma vivax

Sampaio

Fidélis

Marques

et al. 2015

Veterinary Parasitology

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“…The marked alterations in cytokines, APPs, and antioxidants in A. marginaleinfected cattle suggest a high degree of induction of circulating inflammatory and oxidative stress responses during the course of infection. A similar APP response has been shown in a recent study (Nazifi et al 2012). In previous reports it has been proposed that the lesions associated with anaplasmosis in cattle could drive the release of cytokines, which in turn induce the hepatic synthesis of APPs (Latimer et al 2003).…”

Section: Discussionsupporting

confidence: 82%

“…A recent report has shown that A. marginale infection in cattle is associated with an acute phase response with elevated serum sialic acid levels (Nazifi et al 2012). Yet, little is known about the molecular characterisation of A. marginale infection in cattle in Egypt, and currently, relatively few reports are available which describe this clinical condition (Younis et al 2009;Salm et al 2011;Abdel Hamid et al 2014;El-Ashker et al 2015).…”

mentioning

confidence: 99%

Significance of clinical variables and selected biochemical markers in predicting the outcome of bovine anaplasmosis

El-Ashker¹,

Salama²,

El-Sebaei³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:The present study was aimed at evaluating the usefulness of selected inflammatory and oxidative stress markers in predicting the clinical outcome of cattle infected with Anaplasma (A). marginale. The study population consisted of 39 cattle naturally infected with A. marginale. The presumptive diagnosis of this infection was initially achieved on the basis of case history, microscopy and clinical examination findings, and confirmed using A. marginale-specific PCR assays. The diseased cattle were categorised according to the clinical outcome into survivors (n = 26) and non-survivors (n = 13). For comparison, ten clinically healthy cattle were randomly selected and served as controls. Blood was drawn from all examined animals to measure the respective levels of selected cytokines, acute phase proteins, oxidative stress markers, and antioxidant enzyme levels. We found that the clinical examination alone was not conclusive and should be used in conjunction with other diagnostic methods. Nonetheless, the non-surviving animals showed anorexia, frequent coughing, dyspnoea, bloody faeces, recumbency, pale or icteric mucous membranes, and haemoglobinuria. Biochemically, tumour necrosis factor alpha, interleukin (IL)-1β, IL-6, serum amyloid A, fibrinogen, malondialdehye, superoxide dismutase, and catalase levels were significantly higher in diseased cattle compared with controls, and were higher in non-survivors than survivors (P < 0.05). In contrast, reduced glutathione (G-SH) was significantly lower in non-surviving cattle than survivors and controls. Interestingly, a significant correlation was found between parasitaemia of the diseased cattle and most of the measured biochemical variables, with IL-1β and G-SH showing the highest correlation. Our findings clearly demonstrate that A. marginale infection is associated with marked inflammatory and oxidative stress responses, which are higher in non-surviving cattle compared with survivors. The overall degree of cytokine and anti-oxidative disruption may have an important prognostic value for the disease outcome.

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“…An effect of free hemoglobin in serum samples towards reduction of measured Hp concentration has also been found 31,32 . In contrast to those results, Nazifi et al [33][34][35] observed increased in cattle infected theileriosis and anaplasmosis. Our present sudy is consistent with Nazifi's findings, with Hp concentration increased in A. marginale-infected cattle compared to healthy cattle.…”

Section: Discussioncontrasting

confidence: 61%

“…This significant increase indicates an inflammation in cows with anaplasmosis. Nazifi et al 35 indicated that SAA demonstrated more obvious changes than Hp during different levels of parasitemia in A. marginale-infected cattle. However, the current study demonstrated that both Hp and SAA concentrations could be good indicators of inflamation in cattle with A. marginale-associated parasitemia.…”

Section: Discussionmentioning

confidence: 99%

Acute Phase Proteins, Clinical, Hematological and Biochemical Parameters in Dairy Cows Naturally Infected with Anaplasma Marginale

Coşkun¹,

Ekici²,

Güzelbekteş³

et al. 2012

Kafkas Univ Vet Fak Derg

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SummaryThe aim of the study was to evaluate acute phase response via Haptoglobin and serum amyloid-A concentrations in dairy cows naturally infected with Anaplasma marginale. The second aim of the study was to determine the changes in clinical, hematological and biochemical parameters in dairy cows naturally infected Anaplasma marginale. A total of 40 dairy cattle suffering from bovine anaplasmosis were included to the study from a dairy cattle herd. A total of 10 healthy dairy cattle were selected for control group. Analysis of acute phase proteins, hematologic analysis and biochemical analysis was performed in this study. Serum haptoglobin and serum amyloid-A concentrations significantly increased in cattle infected with Anaplasma marginale compared to healthy cattle. All cattle in infected group demonstrated clinical signs of anaplasmosis. Significantly decreased red blood cell count, packed cell volume, and hemoglobin concentration were observed in infected cattle compared to the control group. Serum aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin concentrations were significantly increased in infected cattle compared with the control group. In conclusion, the changes of biochemical and hematological parameters may be indicate of anemia and tissue damage in cattle with anaplasmosis. Serum haptoglobin and serum amyloid-A concentrations could be usefull in evaluate of acute phase response in cattle infected with Anaplasma marginale.

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Acute phase response in cattle infected with Anaplasma marginale

Cited by 20 publications

References 15 publications

Acute-phase protein behavior in dairy cattle herd naturally infected with Trypanosoma vivax

Acute-phase protein behavior in dairy cattle herd naturally infected with Trypanosoma vivax

Significance of clinical variables and selected biochemical markers in predicting the outcome of bovine anaplasmosis

Acute Phase Proteins, Clinical, Hematological and Biochemical Parameters in Dairy Cows Naturally Infected with Anaplasma Marginale

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