Acute phase response and plasma carotenoid concentrations in older women: Findings from the nun study

Boosalis, Maria G.; Snowdon, David A.; Tully, Christine L.; Gross, Myron D.

doi:10.1016/s0899-9007(96)91720-7

Cited by 59 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No association between concentrations of CRP and β-carotene were found in this study, which diverges from Boosalis et al, 26 who observed that the acute phase response was significantly and negatively correlated with the circulating levels of total carotenoids. In the study by Kritchevsky et al, 27 using data from the national health survey of the USA (NHANES III), an inverse relation was also found between CRP and β-carotene concentrations.…”

Section: Resultscontrasting

confidence: 99%

Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

Nogueira

Borges²,

Lameu

et al. 2015

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Objective: patients suffering systemic inflammatory response syndrome (SIRS) constitute a group susceptible to elevated levels of oxidative stress. This study's aim is to evaluate the state of oxidative stress and levels of serum retinol and β-carotene in these patients. Methods: forty-six patients were divided into 2 groups: those those without diet (G1; n=18) and those with enteral nutritional support (G2; n=28). Serum levels of retinol and total carotenoids were measured. C-reactive protein (CRP) levels and Apache scores were also calculated. Oxidative stress was estimated by measuring thiobarbituric acid reactive substance (TBARS) levels. Results: the patients' median age was 66.9 (SD=19.3) years. Lower concentrations of retinol and carotenoids were found in 68.6 and 66.7% of G1, respectively. In G2, despite average vitamin A levels being 8078 + 4035, retinol and β-carotene were considered insufficient (31.2 and 33.4%, respectively). No difference was noted between the 2 groups, according to the variables studied, with the exception being PCR and β-carotene (p=0.002; p=0.01).

show abstract

Section: Resultscontrasting

confidence: 99%

Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

Nogueira

Borges²,

Lameu

et al. 2015

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…Overall, these observations would suggest that higher levels of copper in the blood are likely to contribute to the neutrophilic inflammation involved in the pathogenesis of COPD in humans (Barnes, 2000), rather than result from it (Boosalis et al, 1996). Alternatively, as high levels of serum copper have also been reported in asthma (Malvy et al, 1993;Kadrabova et al, 1996;Vural et al, 2000), in light of the studies cited above (Boosalis et al, 1996;Kennedy et al, 1998;Rice et al, 2001), it is also possible that increased plasma copper contributes to the accelerated decline in lung function observed in those with asthma (Lange et al, 1998).…”

Section: Coppermentioning

confidence: 88%

“…These effects may account for the fact that in animal models, exposure of the lungs to copper elicits a potent proinflammatory response (Rice et al, 2001), and that the neutrophilic inflammation induced by exposure to particulate air pollution appears to be attributable to the exposure to the copper in pollution particles (Kennedy et al, 1998), this latter effect being exacerbated by ceruloplasmin (Kennedy et al, 1998). Overall, these observations would suggest that higher levels of copper in the blood are likely to contribute to the neutrophilic inflammation involved in the pathogenesis of COPD in humans (Barnes, 2000), rather than result from it (Boosalis et al, 1996). Alternatively, as high levels of serum copper have also been reported in asthma (Malvy et al, 1993;Kadrabova et al, 1996;Vural et al, 2000), in light of the studies cited above (Boosalis et al, 1996;Kennedy et al, 1998;Rice et al, 2001), it is also possible that increased plasma copper contributes to the accelerated decline in lung function observed in those with asthma (Lange et al, 1998).…”

Section: Coppermentioning

confidence: 99%

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

et al. 2005

View full text Add to dashboard Cite

Background: Increased dietary intake of antioxidants has been associated with higher lung function, but few studies have used biological markers of antioxidant intake. Objective: This study aimed to determine if antioxidant status, as measured by blood levels, influences lung function. Design: Using a random subsample of 479 participants, aged 18-65 y old, from a larger cross-sectional observational study, the association of forced expiratory volume in 1 s (FEV 1 ) with plasma copper, vitamin C, vitamin E and serum selenium was assessed. Results: An s.d. increase in blood copper level was associated with a difference in FEV 1 of À48 ml (95% confidence intervals: À95, À2 ml, P ¼ 0.04), vitamin C þ 49 ml ( þ 4, þ 94, P ¼ 0.03), vitamin E À15 ml (À62, þ 32, P ¼ 0.53) and selenium þ 52 ml ( þ 7, þ 96, P ¼ 0.02). The sizes of association were not appreciably altered in a mutually adjusted model. Conclusions: Higher levels of serum vitamin C and selenium appear to be associated with higher FEV 1 . The association between higher serum copper and lower FEV 1 requires further study in view of the ubiquitous exposure to this mineral. Sponsorship: National Asthma Campaign and British Lung Foundation.

show abstract

“…However, little is known about how nutritional status is associated with concentrations of inflammatory markers. A number of studies, which generally included either small numbers of participants or were conducted in special populations, have described inverse relationships between C-reactive protein concentration and circulating concentrations of antioxidants (Labadarios et al, 1987;Louw et al, 1992;Boosalis et al, 1996;Sattar et al, 1997;Talwar et al, 1997;Root et al, 1999;Curran et al, 2000;McMillan et al, 2000;Upritchard et al, 2000). In addition, inverse associations were shown between C-reactive protein concentration and concentrations of carotenoids and serum retinol using NHANES III data (Kritchevsky et al, 2000;Stephensen & Gildengorin, 2000;Erlinger et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

et al. 2003

View full text Add to dashboard Cite

Objective: To examine the relationships between circulating concentrations of C-reactive protein and concentrations of retinol, retinyl esters, vitamin C, vitamin E, carotenoids, and selenium. Design: Cross-sectional study using National Health and Nutrition Examination Survey III (1988 data. Setting: United States population. Subjects: Up to 14 519 US noninstitutionalized civilian men and women aged Z20 y. Results: C-reactive protein concentration (dichotomized at the sex-specific 85th percentile) was inversely and significantly associated with concentrations of retinol, retinyl esters, vitamin C, a-carotene, b-carotene, cryptoxanthin, lutein/zeaxanthin, lycopene, and selenium after adjustment for age, sex, race or ethnicity, education, cotinine concentration, body mass index, leisure-time physical activity, and aspirin use. Conclusions: These results suggest that the inflammatory process, through the production of reactive oxygen species, may deplete stores of antioxidants. Whether increased consumption of foods rich in antioxidants or supplementation with antioxidants can provide health benefits to people characterized by elevated C-reactive protein concentrations may be worthy of further study.

show abstract

Acute phase response and plasma carotenoid concentrations in older women: Findings from the nun study

Cited by 59 publications

References 24 publications

Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

Retinol, β-carotene and oxidative stress in systemic inflammatory response syndrome

Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

Contact Info

Product

Resources

About