C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults

Abstract

Objective: To examine the relationships between circulating concentrations of C-reactive protein and concentrations of retinol, retinyl esters, vitamin C, vitamin E, carotenoids, and selenium. Design: Cross-sectional study using National Health and Nutrition Examination Survey III (1988 data. Setting: United States population. Subjects: Up to 14 519 US noninstitutionalized civilian men and women aged Z20 y. Results: C-reactive protein concentration (dichotomized at the sex-specific 85th percentile) was inversely and significantly associated with concentrations of retinol, retinyl esters, vitamin C, a-carotene, b-carotene, cryptoxanthin, lutein/zeaxanthin, lycopene, and selenium after adjustment for age, sex, race or ethnicity, education, cotinine concentration, body mass index, leisure-time physical activity, and aspirin use. Conclusions: These results suggest that the inflammatory process, through the production of reactive oxygen species, may deplete stores of antioxidants. Whether increased consumption of foods rich in antioxidants or supplementation with antioxidants can provide health benefits to people characterized by elevated C-reactive protein concentrations may be worthy of further study.

Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

“…The two aforementioned studies used a different approach by choosing blood concentrations of antioxidants instead of antioxidant intake and are therefore not directly comparable to our study. Comparing blood concentrations of antioxidants with blood CRP concentrations offers the advantage of considering bioavailability in human metabolism; however, it is also a limited approach as Ford et al (25) report themselves. Thus, inflammation may depress antioxidant concentrations in blood and thereby mask the potential CRP, C-reactive protein; tHcy, total homocysteine; NHANES, National Health and Nutrition Examination Survey; TC, total cholesterol; HDL-C, HDL cholesterol; NSAID, non-steroidal anti-inflammatory drugs.…”

Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial

“…Associations between antioxidant vitamins and CRP concentrations have been reported in some [49,50], but not in all epidemiological studies [51,52]. Intervention studies have tried to clarify these ambiguous results; but these have also been inconclusive.…”

Efeitos antioxidantes do selênio e seu elo com a inflamação e síndrome metabólica

“…Com o objetivo de avaliar a associação entre a PCR e o selênio, um grupo de pesquisadores analisou dados de 14.364 participantes do National Health and Nutrition Examination Survey III (1988)(1989)(1990)(1991)(1992)(1993)(1994) 20 . Nesse estudo, as concentrações de PCR foram inversas e significativamente associadas com o selênio, de maneira independente da idade, sexo, etnia, educação, IMC, atividade física de lazer e uso de aspirina.…”

“…Os ROS e a peroxidação lipídica podem promover a produção de citocinas pró-inflamatórias (PCR). Assim, neutralizando o excesso de ROS, bem como a peroxidação lipídi-ca, poderia ser reduzido o estímulo necessário para evitar a ativação da cascata de citocinas pró-iflamatórias 20 .…”