Acute-Phase Proteins of Healthy Horses and Horses Naturally Affected by Colic Syndrome

Souto, P.; Fonseca, Leandro Abreu da; Orozco, Andres M.O.; López, Camilo José Ramirez; Ermita, Pedro Ancelmo Nunes; Filho, Wilson Pinheiro de Carvalho; Girardi, Fabricia Modolo

doi:10.1016/j.jevs.2019.06.002

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…Colic initiates an acute phase reaction ( APR ) in horses with ceruloplasmin ( Cp ) and serum amyloid A ( SAA ) being prominent acute phase proteins ( APP ) [ 40 ]. Albumin which is known as a negative reactant of APR in many species [ 41 ] remained uninfluenced by colic.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits

Dänicke

Saltzmann

Liermann

et al. 2021

Toxins

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Mycotoxin contaminated feed has been associated with colic of horses caused by intestinal disorders. Whether such disease conditions alter the intestinal toxin metabolism and transfer across a compromised mucosal barrier is unknown. A screening approach was used to relate blood residue levels of DON, ZEN and their metabolites to the status of the horses (sick vs. healthy). A total of 55 clinically healthy horses from 6 different farms with varying feeding background served as control for sick horses (N = 102) hospitalized due to colic. ZEN, alpha-zearalenol (ZEL), beta-ZEL and DON were detectable in peripheral blood as indicators for the inner exposure with significant farm effects for alpha- and beta-ZEL. However, the levels in sick horses were similar to all farms. Moreover, the proportion of beta-ZEL of all detected ZEN metabolites as an indicator for the degree of metabolism of ZEN was not different for sick horses but differed amongst the control farms. Although the incidence of DON in blood was generally low and not significantly different amongst healthy and sick horses, the positive samples were nearly exclusively found in sick horses suggesting either a higher toxin transfer, an association of DON with the development of colic or a different feeding background.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits

Dänicke

Saltzmann

Liermann

et al. 2021

Toxins

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show abstract

“…Apo function as structural components in lipid transport. Apo A1 was reported to be the major protein in plasma HDL particles and Apo B-100 is the structural protein found in LDL, IDL and VLDL particles both in humans and horses [30][31][32][33][34][35]. Apo are mainly produced in the liver and their synthesis is controlled primarily by dietary factors and hormones such as insulin and thyroxin [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

A comparative study on the lipidome of normal knee synovial fluid from humans and horses

et al. 2021

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The current limitations in evaluating synovial fluid (SF) components in health and disease and between species are due in part to the lack of data on normal SF, because of low availability of SF from healthy articular joints. Our study aimed to quantify species-dependent differences in phospholipid (PL) profiles of normal knee SF obtained from equine and human donors. Knee SF was obtained during autopsy by arthrocentesis from 15 and 13 joint-healthy human and equine donors, respectively. PL species extracted from SF were quantitated by mass spectrometry whereas ELISA determined apolipoprotein (Apo) B-100. Wilcoxon’s rank sum test with adjustment of scores for tied values was applied followed by Holm´s method to account for multiple testing. Six lipid classes with 89 PL species were quantified, namely phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, phosphatidylethanolamine, plasmalogen, and ceramide. Importantly, equine SF contains about half of the PL content determined in human SF with some characteristic changes in PL composition. Nutritional habits, decreased apolipoprotein levels and altered enzymatic activities may have caused the observed different PL profiles. Our study provides comprehensive quantitative data on PL species levels in normal human and equine knee SF so that research in joint diseases and articular lubrication can be facilitated.

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“…A concentração de proteína no fluido peritoneal pode sofrer aumento diante de um peritônio inflamado, pois, com o aumento da permeabilidade peritoneal, ocorre um implemento no volume da efusão e, consequentemente, uma elevação da quantidade de proteínas (SOUTO et al, 2019). Além do processo inflamatório, o aumento de proteínas totais no líquido peritoneal pode estar ligado ao comprometimento da parede intestinal, fazendo com que fluidos e elementos plasmáticos extravasem para dentro da alça intestinal ou cavidade peritoneal, alterando a concentração (VALADÃO et al,2004).…”

Section: Discussionunclassified

Análise Do Líquido Peritoneal No Diagnóstico De Cólica Equina

Lira

Lima

Leite

et al. 2019

Iniciac cient Cesumar

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A cólica equina é um processo patológico doloroso de início repentino, que possui repercussão sistêmica e requer um rápido diagnóstico e tratamento, sendo classificada como um abdômen agudo. É uma patologia com a maior taxa de óbito na espécie equina. A análise do líquido peritoneal pode auxiliar na classificação do tipo de doença, na determinação da severidade da lesão abdominal e na origem do problema. Esse estudo avaliou o líquido peritoneal de 12 equinos, sendo dez animais hígidos e dois com síndrome cólica. Após coleta por abdominocentese, as amostras foram analisadas quanto às suas propriedades físicas, celularidade e bioquímica (proteína total, albumina, fosfatase alcalina e glicose). A análise do LP dos animais com cólica diferiu quanto à sua aparência e apresentaram elevação na contagem celular e concentração de proteínas. A avaliação do líquido peritoneal é de realização factível na rotina veterinária pela acessibilidade, rapidez e baixo custo.

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Acute-Phase Proteins of Healthy Horses and Horses Naturally Affected by Colic Syndrome

Cited by 14 publications

References 19 publications

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits

Evaluation of Inner Exposure of Horses to Zearalenone (ZEN), Deoxynivalenol (DON) and Their Metabolites in Relation to Colic and Health-Related Clinical-Chemical Traits

A comparative study on the lipidome of normal knee synovial fluid from humans and horses

Análise Do Líquido Peritoneal No Diagnóstico De Cólica Equina

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