Chemotherapy agents have some undesirable and non-selective cytostatic effects. Considering that kidneys are vulnerable to drug-induced toxicity, this study evaluated renal injury caused by vincristine sulfate (VS) in 12 female dogs diagnosed with transmissible venereal tumor (TVT). The animals were treated with VS (0.025 mg/kg IV) every 7 days for 4 weeks. During treatment, the animals were subjected to clinical examination, blood count, serum measurement of symmetric dimethylarginine (SDMA), blood urea nitrogen (BUN), creatinine, alanine aminotransferase, and alkaline phosphatase. In addition, urinalysis and urinary gamma-glutamyl transferase (GGT) measurements were performed. All parameters were determined three times: before beginning the treatment (T0), after 14 days (T1), and after 28 days (T2). During the study period, there were no changes in serum urea or creatinine levels, urine specific gravity, or persistent proteinuria. Furthermore, urinary GGT measurement did not indicate tubular lesions, and consistent elevation of SDMA was found in only one patient above the reference range. The results showed that weekly therapy with VS as a single agent for 28 days does not induce renal injury in most cases.
A cólica equina é um processo patológico doloroso de início repentino, que possui repercussão sistêmica e requer um rápido diagnóstico e tratamento, sendo classificada como um abdômen agudo. É uma patologia com a maior taxa de óbito na espécie equina. A análise do líquido peritoneal pode auxiliar na classificação do tipo de doença, na determinação da severidade da lesão abdominal e na origem do problema. Esse estudo avaliou o líquido peritoneal de 12 equinos, sendo dez animais hígidos e dois com síndrome cólica. Após coleta por abdominocentese, as amostras foram analisadas quanto às suas propriedades físicas, celularidade e bioquímica (proteína total, albumina, fosfatase alcalina e glicose). A análise do LP dos animais com cólica diferiu quanto à sua aparência e apresentaram elevação na contagem celular e concentração de proteínas. A avaliação do líquido peritoneal é de realização factível na rotina veterinária pela acessibilidade, rapidez e baixo custo.
Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver.
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