Acute pancreatitis: the substantial human and financial costs

Neoptolemos, John P.; Raraty, Michael; Finch, M. D.; Sutton, Robert

doi:10.1136/gut.42.6.886

Cited by 240 publications

(158 citation statements)

References 66 publications

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“…The mean age of presentation in world literature was 6th decades. 11 The difference is probably explained due to alcohol being common in this part of world.…”

Section: Discussionmentioning

confidence: 99%

PANC 3 score as a simple cost-effective scoring system in predicting severity of acute pancreatitis

et al. 2017

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Background: Acute pancreatitis presents as acute abdomen, is an inflammatory process of the pancreas associated with local and systemic complications requiring, in such cases, an intensive care. At present, there are lots of scores (such as Ranson’s, APACHE II, bedside index for severity in acute pancreatitis) that help us in predicting severity at the time of admission, but these are time consuming or require complex calculation and are costly. Our aim here is to analyse the simplified stratification system of the PANC 3 score, and its assessment in Predicting Severity of Acute Pancreatitis as decided by modified Marshals score.Methods: It is a prospective analytical observational study in which 74 patients were evaluated with PANC 3 scoring, who were diagnosed with acute pancreatitis and admitted to Dept. Of General Surgery, MKCG.Results: The results showed that PANC3 score had a 95.91% specificity, 68% sensitivity, 89.47% positive predictive value, and 85.45% negative predictive value, 86.48% diagnostic accuracy.Conclusions: PANC3 scoring system is one of the better systems because the three criteria used (haematocrit, body mass index, and pleural effusion) are simple, easy to assess, readily available, and economic Hence, the PANC3 score is a cost-effective, promising score that helps in predicting the severity of acute pancreatitis and triaging the patient, leading to prompt management.

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“…The mean age of presentation in world literature was 6th decades. 11 The difference is probably explained due to alcohol being common in this part of world.…”

Section: Discussionmentioning

confidence: 99%

PANC 3 score as a simple cost-effective scoring system in predicting severity of acute pancreatitis

et al. 2017

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“…The investigators also concluded that the average overall hospital cost was $96,891. Fortunately, AP patients typically regain complete functional ability and can return to employment and other normal activities [9] [10].…”

Section: Discussionmentioning

confidence: 99%

Primary Isolated Case of Drug Induced Pancreatitis Misdiagnosed as Idiopathic Pancreatitis

Ghani¹,

Saba²,

Hussain³

et al. 2014

CRCM

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Drug Induced Pancreatitis is a very common cause of acute pancreatitis in older patients and is often treated by just symptomatic treatment. An old hypertensive lady was admitted repeatedly to emergency department and treated as Idiopathic Pancreatitis. Initial labs showed elevated pancreatic enzymes. Detailed history showed that increase in thiazides dosage was the cause of her pancreatitis. It was later diagnosed as a case of thiazide induced pancreatitis. It is important to consider medication as a cause of acute pancreatitis in especially in older people presenting with acute pancreatitis without common risk factors.

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“…Pancreatic infections occur at the first 4 weeks of the disease and reach to peak levels at 2 or 3 weeks. It has been reported that pancreatic infections are responsible for 80% of the deaths in AP (Neoptolemos et al, 1998;Quamruddin and Chadwick, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of glutamine-enriched total parenteral nutrition on acute pancreatitis

et al. 2007

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Aim: This study was performed to determine the effects of glutamine enriched total parenteral nutrition (TPN) on the patients with acute pancreatitis (AP). Method: Forty patients with AP, who had Ranson's score between 2 and 4 received either standard TPN (control group) or TPN with glutamine (treatment group). The patients in the treatment group received TPN containing 0.3 g/kg/days glutamine. At the end of the study, patients were evaluated for nutritional and inflammatory parameters, length of TPN and length of hospital stay.Results: The length of TPN applications were 10.573.6 days and 11.672.5 days, and the length of hospital stays were 14.274.4 and 16.473.9 days for the treatment and control groups (NS), and the complication rates in the treatment and control groups were 10 and 40%, respectively (Po0.05). The transferrin level increased by 11.7% in the group that received glutamine-enriched TPN (Po0.05), whereas the transferrin level decreased by 12.1% in the control group (NS). At the end of the study, slight but not significant changes were determined in both groups in fasting blood sugar, albumin, blood urea nitrogen (BUN), creatinine, total cholesterol concentrations, aspartate aminotransferase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) activities, leukocytes, CD 4 , CD 8 , serum Zn, Ca and P levels compare to the baseline levels (NS). Significant decreases were determined in serum lipase, amylase activities and C-reactive protein (CRP) levels in both groups (Po0.05). Conclusions:The results of this study have shown that glutamine supplementation to TPN have beneficial effects on the prevention of complications in patients with AP.

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Acute pancreatitis: the substantial human and financial costs

Cited by 240 publications

References 66 publications

PANC 3 score as a simple cost-effective scoring system in predicting severity of acute pancreatitis

PANC 3 score as a simple cost-effective scoring system in predicting severity of acute pancreatitis

Primary Isolated Case of Drug Induced Pancreatitis Misdiagnosed as Idiopathic Pancreatitis

Effects of glutamine-enriched total parenteral nutrition on acute pancreatitis

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