Acute Pancreatitis in Primary Hyperparathyroidism: A Population-Based Study

Khoo, Teck Kim; Vege, Santhi Swaroop; Abu-Lebdeh, Haitham S.; Ryu, Euijung; Nadeem, Sarah; Wermers, Robert A.

doi:10.1210/jc.2008-1965

Cited by 80 publications

(52 citation statements)

References 14 publications

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“…PHPT has been linked to pancreatitis in several retrospective studies even though its link remains controversial (4). Pancreatitis risk has been related to serum calcium, but data remains conflicting (5). Calcium serum level might predispose pancreatitis due to activation of pancreatic calcium sensors (6).…”

Section: Resultsmentioning

confidence: 99%

Hypercalcemia, necrotizing pancreatitis and bone lesions: a benign cause

Rauber

Kihm

Merle

2017

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Section: Resultsmentioning

confidence: 99%

Hypercalcemia, necrotizing pancreatitis and bone lesions: a benign cause

Rauber

Kihm

Merle

2017

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“…Carnaille et al found significantly elevated serum calcium levels to be of major importance in the development of pancreatitis in patients with PHP [11]. However, more recent report indicated that the estimated hazard ratio of acute pancreatitis for PHP relative to the control subjects was 0.84 (P = 0.89) [12]. Primary hyperparathyroidism should be suspected if increased levels of serum calcium are detected during the first episode of acute pancreatitis.…”

Section: Discussionmentioning

confidence: 97%

Ectopic mediastinal parathyroid adenoma: a cause of acute pancreatitis

Imachi

Murao

Kontani

et al. 2009

Endocr

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A 38-year-old male was admitted to our hospital with epigastric pain, and he was confirmed to have acute exudative pancreatitis. After the episode of acute pancreatitis subsided, laboratory investigation revealed increased serum calcium (12.0 mg/dl), decreased serum phosphorus (2.7 mg/dl), and increased serum parathyroid hormone (intact) levels (131 pg/ml). A computed tomography (CT) scan of the neck did not reveal any mass lesions in the parathyroid gland. However, (99m)Tc sestamibi scintigraphy revealed that there was one functioning parathyroid gland in the upper mediastinum. Combined (99m)Tc sestamibi scintigraphy and CT scan confirmed the diagnosis of primary hyperparathyroidism in the mediastinum. Microscopic examination revealed the presence of a parathyroid adenoma (1.3 x 0.4 cm(2)) adjacent to the atrophic parathyroid gland in right thymus gland. We report the case of a patient diagnosed with primary hyperparathyroidism due to an ectopic mediastinal parathyroid adenoma. An ectopic mediastinal parathyroid adenoma may manifest as an episode of acute pancreatitis. Preoperative investigation to determine the exact location of an adenoma should include two types of imaging studies, preferably (99m)Tc sestamibi scintigraphy and CT of the neck and chest.

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“…In a population based study done in Minnesota is suggested that the relationship between acute pancreatitis and primary hyperparathyroidism is a chance association. That contradicts reports based primarily upon surgical or hospital based cohorts, which likely selects the most severe cases [57,58].…”

Section: Hypercalcemiamentioning

confidence: 92%

Etiology of acute pancreatitis

2014

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AbstractAcute pancreatitis is a common disease with a benign course in the majority of patients, but it is associated with serious morbidity, and mortality close to 20% in up to 20% of cases. The incidence of acute pancreatitis seems to be rising in western countries. About 75% of all cases are caused by gallstones or alcoholism. The relative rate of gallstones versus alcohol as etiology depends on the age and the area of enrolment. A thorough evaluation allows cause identification in another 10% of cases, leaving about 15–20% as idiopathic. The most common causes, and a growing list of less frequent and sometimes very rare and controversial etiologies, are reviewed in this article. A classification on the pathogenic mechanisms of causes of acute pancreatitis based is used in this Review. The approach, or suggested plan of investigations, to determine the etiology of acute pancreatitis, based on the most recently published Guidelines is outlined.

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Acute Pancreatitis in Primary Hyperparathyroidism: A Population-Based Study

Cited by 80 publications

References 14 publications

Hypercalcemia, necrotizing pancreatitis and bone lesions: a benign cause

Hypercalcemia, necrotizing pancreatitis and bone lesions: a benign cause

Ectopic mediastinal parathyroid adenoma: a cause of acute pancreatitis

Etiology of acute pancreatitis

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