Acute Otitis Media Caused by Drug-resistant Bacteria: Correlation with Antibiotic Treatment

Sakakura, Koichi; Chikamatsu, Kazuaki; Furukawa, Makoto; Shibasaki, Mayumi; Takegoshi, Tetsuo; Takahashi, Katsumasa; Furuya, Nobuhiko

doi:10.1080/00016480410017855

Cited by 4 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detection of drug-resistant bacteria in young children with AOM was less frequent in this study than in previous studies conducted in general and university hospitals [8,18,19]. In such hospitals, the proportion of patients with serious AOM seems to be higher.…”

Section: Discussioncontrasting

confidence: 80%

Factors associated with the presence of drug-resistant bacteria and recurrent acute otitis media in children – a study in a private clinic

Kikuta

Ushio

Fujimaki³

et al. 2007

Acta Oto-Laryngologica

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 80%

Factors associated with the presence of drug-resistant bacteria and recurrent acute otitis media in children – a study in a private clinic

Kikuta

Ushio

Fujimaki³

et al. 2007

Acta Oto-Laryngologica

View full text Add to dashboard Cite

show abstract

Prevention and Treatment of Penicillin-Resistant Streptococcus pneumoniae Meningitis After Intracraniofacial Surgery With Distraction Osteogenesis

Watanabe¹,

Akizuki²

2008

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

The prevalence of penicillin-resistant Streptococcus pneumoniae (PRSP) meningitis has increased worldwide, particularly in East Asia and the United States. We recently experienced a case of PRSP meningitis that developed during frontofacial distraction. The patient was a 7-year-old girl with Crouzon disease who was treated by frontofacial monobloc/Le Fort IV minus glabellar osteotomy with quadruple internal distraction devices. Penicillin-resistant Streptococcus pneumoniae meningitis was diagnosed after surgery and treated successfully with meropenem (a carbapenem) at 120 mg kg d every 8 hours, ceftriaxone (a third-generation cephalosporin) at 100 mg kg d every 12 hours, and vancomycin (a glycopeptide) at 45 mg kg d every 6 hours. This case indicates that severe and fatal bacterial meningitis may occur as a postoperative complication due to multidrug-resistant bacteria indigenous to the nasal cavity after simultaneous osteotomy of the cranium and facial bone in intracraniofacial surgery, such as that for syndromic craniosynostosis and hypertelorbitism. In such cases, preventive strategies should include preoperative administration of pneumococcal vaccine, preoperative screening of nasal bacterial flora by nasal culture test, and prior administration of a carbapenem with good cerebrospinal fluid transfer or a third- or fourth-generation cephem covering PRSP. Postoperatively, suspected meningitis may be treated with a combination of the 3 drugs used in our case, in parallel with emergency cephalic contrast computed tomography and culture tests of blood and cerebrospinal fluid. Our experience suggests that these measures will facilitate a successful outcome in frontofacial distraction osteogenesis.

show abstract

Emerging therapies for the treatment and prevention of otitis media

Aliphas

Prufer

Grundfast

2006

Expert Opinion on Emerging Drugs

View full text Add to dashboard Cite

Otitis media is one of the most common disorders occurring in children, and there is growing concern that bacteria are quickly becoming resistant to antimicrobials. As a result, global antibiotic treatment is no longer the standard of care and treatment of otitis media has changed dramatically in the last decade. In addition to new antimicrobials currently in development, the effects of the pneumococcal conjugate vaccine are just beginning to be understood. Furthermore, new surgical techniques are for the first time being tested as alternatives for tympanostomy tubes for recurrent acute otitis media. This review discusses current and emerging otitis media therapeutics, with particular attention to acute otitis media. Topics include antimicrobial use, antimicrobial resistance, effects of vaccination and new surgical techniques.

show abstract

Acute Otitis Media Caused by Drug-resistant Bacteria: Correlation with Antibiotic Treatment

Cited by 4 publications

References 16 publications

Factors associated with the presence of drug-resistant bacteria and recurrent acute otitis media in children – a study in a private clinic

Factors associated with the presence of drug-resistant bacteria and recurrent acute otitis media in children – a study in a private clinic

Prevention and Treatment of Penicillin-Resistant Streptococcus pneumoniae Meningitis After Intracraniofacial Surgery With Distraction Osteogenesis

Emerging therapies for the treatment and prevention of otitis media

Contact Info

Product

Resources

About