Acute Motor Axonal Neuropathy in a Child With Atypical Presentation

Lee, Kyung Soo; Han, Seung Hoon

doi:10.1097/md.0000000000000392

Cited by 5 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As it was previously stated that the frequency of AIDP subtype of GBS is high in US and Western Europe, it should be stated as well that the AMAN is frequent (up to 65%) in the study conducted in China [4]. NCS and cerebrospinal fluid analysis is important investigations that help confirm the diagnosis of GBS [5]. Although GBS is a relatively uncommon condition, the consequences of a missed or delayed diagnosis and delayed treatment can lead to progression of muscle weakness and a worse outcome [10].…”

Section: Discussionmentioning

confidence: 87%

“…Based on clinical features with motor involvement, electrophysiological investigation, as well as the normal laboratory findings, this patient was diagnosed with AMAN subtype of GBS with severe painful legs as atypical presentation of this condition. Lee and Han [13] as well as Neocleous et al [14] reported the first case of AMAN confirmed by electrophysiological studies that was accompanied by severe pain of the entire body. In our patient, at the beginning, severe pain sensations were treated with opioids and Carbamazepine.…”

Section: Discussionmentioning

confidence: 95%

“…The most frequent subtype of GBS in North America and Europe is AIDP, which accounts for up to 90% of GBS cases [3,4]. AMAN is characterized clinically by nearly pure motor syndrome without sensory involvement and final diagnosis of AMAN is based on electrophysiological findings such as decreased amplitude of compound muscle action potential (CMAP) without any evidence of demyelination or change in sensory nerve action potential (SNAP) [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Severe painful lower limbs and refusal of the leg reliance as atypical presentation of Gullain Barre syndrome

et al. 2019

View full text Add to dashboard Cite

Introduction Guillain-Barre syndrome (GBS) is the most common cause of acute flaccid paralysis in healthy infants and children. Acute motor axonal neuropathy (AMAN) is a type of GBS characterized by motor syndrome with no sensory symptoms. Case outline Authors describe a six-and-a-half year old girl with atypical clinical presentation of AMAN with severe painful lower limbs and refusal of the leg reliance with typical findings on nerves conduction studies. Conclusion Despite the nerve conduction study findings, atypical forms of AMAN and GBS are possible. Pain symptoms must be taken very seriously and treated careful by the clinicians.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Severe painful lower limbs and refusal of the leg reliance as atypical presentation of Gullain Barre syndrome

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Entretanto, de FAG Journal of Health -ISSN 2674-550X, 2020 157 DOI: 10.35984/fjh.v2i1.186 acordo com os critérios de Brighton, anticorpos anti-gangliosídeos não são necessários para o diagnóstico da patologia(AL-SAFFAR; AL-FATLY, 2018). O diagnóstico final da AMAN é feito através do estudo eletrofisiológico, através da evidência de redução importante da amplitude do potencial de ação muscular composto (CMAP), o qual pode estar ausente em casos graves (DIMACHKIE;BAROHN, 2013 e LEE;HAN, 2015).…”

Section: Relato Do Casounclassified

Neuropatia Axonal Motora Aguda Com Piora Ao Tratamento Com Imunoglobulina: Relato De Caso

Soares

Soares²,

Chagas³

et al. 2020

FAG J of health

View full text Add to dashboard Cite

Neuropatias são condições que acometem o sistema nervoso periférico, podendo estar relacionadas a doenças sistêmicas. A síndrome de Guillain-Barré é o principal exemplo quando se fala em polirradiculoneuropatia aguda, geralmente seu quadro é associado a uma infecção prévia de Campylobacter jejuni sendo a neuropatia axonal motora aguda uma de suas variantes motoras puras e tem sua incidência variante de acordo com o espaço geográfico estudado entre 30 a 65% dos quadros totais de Guillain-Barré. As manifestações dessa variação são paralisia das extremidades de caráter simétrico e ascendente, arreflexia, com acometimento da musculatura respiratória, ocular e facial. Descrevemos um caso no qual o paciente apresentou, após uma infecção de vias aéreas superiores, parestesia de mãos e pés associada a fraqueza de caráter progressiva e ascendente, diplopia e disfagia, evoluindo para insuficiência respiratória aguda, após exames comprobatórios foi iniciado protocolo de tratamento com Hiperimunoglobulina Humana Endovenosa para o tratamento de Síndrome de Guillain-Barré. O paciente evoluiu com tetraplegia flácida e necessidade de ventilação mecânica após isso, no exame de eletroneuromiografia evidenciou-se Neuropatia Axonal Motora Aguda. Por fim novo ciclo de imunoglobulina humana intravenosa obtendo resultado. O paciente recebeu alta hospitalar com sequelas motoras, mantendo acompanhamento domiciliar multiprofissional após 63 dias de internamento em unidade de terapia intensiva.

show abstract

“…Cerebellar ataxia has also been reported in association with acute motor axonal neuropathy (Bae and Kim 2005;Liu 2010). Lee and Han reported another case of acute motor axonal neuropathy in a 3-year-old male child with atypical presentation and CNS involvement (Lee and Han 2015). This patient presented with complaints of severe pain and burning sensations as well as flaccid paralysis of the whole body that was worse in the lower extremities.…”

Section: Clinical Manifestations Presentation and Coursementioning

confidence: 98%

Acute Motor Axonal Neuropathy

Bromberg

Peripheral Neuropathies

View full text Add to dashboard Cite

This article includes discussion of acute motor axonal neuropathy, Chinese paralytic syndrome, axonal GBS, acute motor-sensory axonal neuropathy (AMSN), acute inflammatory demyelinating polyradiculoneuropathy (AIDP), and Miller Fisher syndrome (MFS). The foregoing terms may include synonyms, similar disorders, variations in usage, and abbreviations. Overview Acute motor axonal neuropathy is the most frequent axonal variant of Guillain-Barré syndrome (GBS) and is often used synonymously with the term axonal GBS. This review describes clinical and electrodiagnostic features of acute motor axonal neuropathy and compares it with the acute inflammatory demyelinating polyradiucloneuropathy variant of Guillain-Barré syndrome. Pathology and pathogenesis of this disorder are discussed to highlight the theme of molecular mimicry. Key points • Acute motor axonal neuropathy is a variant of Guillain-Barré syndrome with predominant motor axon dysfunction or injury, and it is strongly associated with antecedent Campylobacter jejuni infection and the presence of anti-ganglioside antibodies. • In North America and Europe, acute motor axonal neuropathy is much less frequent than acute inflammatory demyelinating polyradiucloneuropathy.

show abstract

Acute Motor Axonal Neuropathy in a Child With Atypical Presentation

Cited by 5 publications

References 8 publications

Severe painful lower limbs and refusal of the leg reliance as atypical presentation of Gullain Barre syndrome

Severe painful lower limbs and refusal of the leg reliance as atypical presentation of Gullain Barre syndrome

Neuropatia Axonal Motora Aguda Com Piora Ao Tratamento Com Imunoglobulina: Relato De Caso

Acute Motor Axonal Neuropathy

Contact Info

Product

Resources

About