Acute Monoblastic Leukæmia in Child Receiving Chlorambucil for Juvenile Rheumatoid Arthritis

Lebranchu, Y; Drucker, Jennifer; Nivet, Hubert; Rolland, J. C.; Grenier, B; Lejars, Odile; Lamagnere, J. P.; Buriot, D

doi:10.1016/s0140-6736(80)91138-1

Cited by 12 publications

(1 citation statement)

References 4 publications

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“…Though com plete clinical hematological remission has been re ported recently [49], 4 of our patients died within 4 months, whereas 1 patient died 1 Vi years after the diagnosis of AML probably due to slow progression of disease as he presented with smouldering leukemia. The development of refractory acute leukemia re mains the potential danger of cytotoxic therapy.…”

Section: Discussionmentioning

confidence: 70%

Therapy-Related Leukemia

Advani¹,

Doval²,

Gopal³

et al. 1983

Oncology

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5 patients developed acute nonlymphocytic leukemia (ANLL) 2–4 years following the use of various cytotoxic agents for other primary disease. Alkylating agents were responsible for development of ANLL in 3 patients while mitomycin-C and methotrexate appear to be linked with leukemia transformation in the remaining 2 patients. 3 patients had a prolonged preleukemic phase preceding ANLL. Pancytopenia observed in 4 of 5 patients favors drug-induced stem cell damage leading to relatively resistant leukemia. Although the incidence of secondary leukemia is not very high, careful use of cytotoxic agents is needed to minimize therapy-linked neoplasms.

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Section: Discussionmentioning

confidence: 70%

Therapy-Related Leukemia

Advani¹,

Doval²,

Gopal³

et al. 1983

Oncology

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Drugs in Lung Disease

Seaton¹

2000

Crofton and Douglas's Respiratory Diseases

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Waldenström macroglobulinemia terminating in acute leukemia: A report of three cases

1983

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Acute leukemia was observed to develop in three patients with Waldenstöm macroglobulinemia. Each patient had been treated with cytotoxic drug therapy. Pancytopenia preceded the onset of the terminal leukemia in two of the three cases. The acute leukemias were all of acute myelogenous type. All of the patients died soon after the development of the terminal leukemia. A number of recent reports have documented acute terminal leukemia in patients with macroglobulinemias and multiple myeloma, as well as other malignant and nonmalignant diseases. The role of the cytotoxic drugs, especially chlorambucil, cyclophosphamide, and melphalan, in leukemogenesis has been raised by these recent reports.

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Acute Monoblastic Leukæmia in Child Receiving Chlorambucil for Juvenile Rheumatoid Arthritis

Cited by 12 publications

References 4 publications

Therapy-Related Leukemia

Therapy-Related Leukemia

Drugs in Lung Disease

Waldenström macroglobulinemia terminating in acute leukemia: A report of three cases

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