Drugs in Lung Disease

Seaton, Douglas

doi:10.1002/9780470695999.ch9

Cited by 2 publications

(2 citation statements)

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“…In addition, use of dexamethasone is not recommended which may be due the fact that it has no mineralocorticoid activity. [ 13 ] Methyl prednisolone also has minimal mineralocorticoid activity as compared to prednisolone and hydrocortisone. [ 13 ] Annane et al .…”

Section: Discussionmentioning

confidence: 99%

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Role of steroids in septic shock: Assessment of knowledge, attitudes and practices among intensivists practising in Hyderabad

Juneja

Gopal

Satapathy

et al. 2009

Indian Journal of Critical Care Medicine

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Context:Use of steroids in septic shock is an issue of contention, more so with two major trials reporting conflicting results.Aims:To assess the current knowledge, attitudes and practices (KAP) related to the role of steroids in septic shock among intensivists practising in Hyderabad.Setting, Design, Materials and Methods:Questionnaires containing 10 questions pertaining to the role of steroids in septic shock, were distributed to 76 intensivists during the monthly critical care meeting.Results:A great majority of intensivists (82%) agreed that the role of steroids is restricted to septic shock not responding to vasopressors. There was no clear consensus regarding the role of corticotropin stimulation test or the timing of total cortisol level testing, if it has to be performed. Hydrocortisone was clearly the choice of steroid for most intensivists and intravenous bolus injection being the preferred route of administration. There was no agreement regarding the dose of steroids, the role of fludrocortisone and whether steroids should be tapered. Most of the respondents did not extend the steroid therapy beyond seven days and the most common side effect reported was hyperglycemia.Conclusion:There is a lot of ambiguity in the knowledge, attitudes or practices regarding role of steroids in septic shock among intensivists in Hyderabad. Uniform policies and protocols need to be devised at institutional level, with multispecialty inputs, and doctors need to be familiarized accordingly.

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Section: Discussionmentioning

confidence: 99%

“…[ 13 ] Methyl prednisolone also has minimal mineralocorticoid activity as compared to prednisolone and hydrocortisone. [ 13 ] Annane et al . [ 2 ] recommended addition of fludrocortisone (50 μg/day) for its mineralocorticoid effect of retaining sodium and water, and hence increasing blood pressure.…”

Section: Discussionmentioning

confidence: 99%