The CHR includes the vast majority of factor concentrate users and is therefore ideal as the basis for a national monitoring system.

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Summary. During storage in the liquid state, red cells progressively lose their ability to survive in vivo and they become less deformable. An opportunity to test the hypothesis that these two changes are directly related arose when a donor was encountered whose red cells survived particularly badly after storage. It was found that red cells from this donor lost deformability abnormally rapidly during storage. Measurement of red cell deformability after storage may be of value in predicting the viability of the cells.

Cardiovascular disease risk factors and events are relatively common in PWH. PWH can be safely treated for CVD events with similar procedures as the non-PWH populations, though specific clotting factor prophylaxis protocols are not well defined.

CD7 antigen, a T-cell lineage associated antigen, is expressed in a minority of patients with acute myeloid leukemia (AML). The biologic and clinical significance of this finding is not clearly established. In this retrospective study of patients with de novo acute myeloid leukemia, we have identified CD7 expression and analyzed its association with markers expressed early in hemopoietic ontogeny and clinical parameters. Among 60 consecutive AML patients, we found six (10%) expressing CD7 on leukemic cells. There were five males and one female and the mean age was 59.6 years (age range: 32-76 years) with no demographic peculiarities. The FAB subtypes were: M0 (2), M1 (1), M2 (1), and M4 (2). CD7 expression was associated with immature antigens CD34, HLA-DR, and terminal deoxynucleotidyl transferase (TdT) and antigen receptor gene rearrangements (rear-rangements of T-cell receptor gamma chain in 6/6 and immunoglobulin heavy chain in 2/6). Hepatomegaly was present in three and this was associated with splenomegaly with lymphadenopathy in one patient. Mediastinal or central nervous system involvement was absent. Complete remission was achieved in two patients with standard chemotherapy; one of these is in remission and alive (5 years later), while one died following relapse 9 months later. Three patients had significantly lower response to standard therapeutic regimen (two died during induction and one died 7 months later without ever achieving complete remission). One patient has been excluded in determining the prognostic significance of CD7 due to early death. Our results suggest origin of CD7+ AML from early hemopoietic precursors and indicate biologic aggressiveness in a significant proportion of patients. We suggest evaluation of CD7 in all patients with AML at the time of diagnosis in view of poor clinical outcome. Am.

Iron deficiency anemia (IDA) has been proposed as an etiological factor for ischemic stroke. There is considerable evidence for this for pediatric transient ischemic attack (TIA) and ischemic stroke [1][2][3][4][5][6][7] , and IDA has emerged in a recent case control study as a significant risk factor for stroke in otherwise healthy young children 7 . In adult ischemic stroke, however, it is less well-established that IDA confers risk. This hypothesis was first supported by a series of case reports linking IDA to thrombocytosis and stroke, implicating reactive thrombocytosis as a contributing mechanism [8][9][10] . A follow-up study to the First National Health and Nutrition Examination Survey (NHANES I) identified a significant U-shaped relationship between transferrin saturation and stroke in white women 45-74 years of age 11 , suggesting an increased risk for stroke at both low and L'apport alimentaire a été évalué au moyen du questionnaire de fréquence Clue II. Résultats : Les estimés de prévalence étaient de 6,4% pour l'AFP, 2,1% pour le déficit en fer sans anémie et 6,4% pour l'anémie due à une autre cause. La prévalence de l'AFP était significativement plus élevée que celle publiée dans NHANES III, estimée pour l'âge et le sexe, pour les individus de 70 ans et plus [test de proportion; hommes p = 0,038 (n = 37) ; femmes p = 0,002 ( n = 44)]. La comparaison entre la prévalence de l'AFP dans notre groupe de patients et celle observée dans certains groupes témoins tirés de la base de données de NHANES III a fourni un rapport de cotes (RC) de 6,3 (IC à 95% : 0,8 à 53,7) ce qui n'était pas significatif au point de vue statistique (méthode exacte de Fischer ; n = 94; p = 0,118). L'analyse de régression linéaire multivariée de l'apport alimentaire avec les indicateurs de statut en fer (n = 58) a montré que seulement la prise de suppléments de fer (p = 0,013 et l'apport en fer hémique (p = 0,038) étaient des facteurs de prédiction négatifs de la capacité de liaison du fer (p < 0,05). Conclusion : Selon ces observations, il serait justifié de procéder à une étude cas-témoin pour examiner si l'AFP est un facteur de risque de l'AVCI chez les patients âgés.

An ektacytometer was used to measure red blood cell deformability during blood storage for 42 days at different degrees of cell packing in citrate-phosphate-dextrose preservative. Observed changes in deformability were studied in relationship to red blood cell adenosine triphosphate (ATP) levels, lipid content, osmotic fragility, and hematocrit during storage. Decrease in whole cell deformability as measured in isotonic medium did not occur until cellular ATP levels were reduced to less than 30 percent of initial values. The rate of deformability loss during storage increased with increased degrees of cell packing because of more rapid substrate depletion. The loss in isotonic deformability was further magnified when deformability measurements were carried out in hypotonic media, suggesting that a reduction in surface area-to-volume ratio was the dominant cause of the reduced deformability of stored red blood cells. Marked spherocytosis, decreased membrane lipid content and increased osmotic fragility confirmed loss of membrane surface area during storage. The significantly higher rate of deformability loss observed in packed red blood cells suggests that careful control of storage hematocrit may be necessary to avoid loss of cellular deformability and possibly posttransfusion viability.