Acute Kidney Injury and Chronic Kidney Disease: It’s a Two-Way Street

Kline, Jason; Rachoin, Jean‐Sebastien

doi:10.3109/0886022x.2013.766572

Cited by 22 publications

(19 citation statements)

References 29 publications

(33 reference statements)

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“…AKI leads to high rates of chronic kidney disease, in both adults and children. 4-6 Unfortunately, the details of how hosts recover (or do not recover) from acute injury are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury

Basu¹,

Donaworth²,

Siroky

et al. 2015

Renal Failure

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Acute kidney injury (AKI) leads to chronic kidney disease. The mechanisms involved with recovery from AKI are poorly understood and molecular mediators responsible for healing and restoration of kidney function are understudied. We previously discovered differential expression of matrix metalloproteinase-8 (MMP-8) mRNA and protein in patients with severe sepsis associated AKI versus sepsis without AKI. Here, we demonstrate the involvement of MMP-8 in purely ischemic AKI. Mice subjected to 30 min of bilateral renal ischemia developed increased plasma creatinine and MMP-8 expression within 24 h versus sham controls. After an initial surge and subsequent return toward baseline, both kidney MMP-8 expression and activity exhibited a late increase (Days 5–7 post-ischemia reperfusion) in mice subjected to AKI. Neutrophil infiltration of the kidney was significantly higher after AKI in wild-type mice than in MMP-8 null mice, starting at 4 days. Additionally, MMP-8 null mice subjected to AKI demonstrated a persistent histopathologic and functional injury and worsened health (greater overall weight loss) versus wild-type cohorts after seven days. Taken together, our findings suggest that MMP-8 is involved with restoration of baseline kidney health after ischemic kidney injury and that a potential mechanism involves the interaction of MMP-8 and neutrophil recruitment to the site of injury.

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Section: Introductionmentioning

confidence: 99%

Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury

Basu¹,

Donaworth²,

Siroky

et al. 2015

Renal Failure

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show abstract

“…AKI causes abrupt loss of kidney function and develops rapidly over a short time period (Kline & Rachoin, ). People with AKI may have an increased risk of CKD in the future (Pannu, ).…”

Section: Discussionmentioning

confidence: 99%

Curcumin alleviates ischemia reperfusion‐induced late kidney fibrosis through the APPL1/Akt signaling pathway

Chen

Fan

Huang

et al. 2018

Journal Cellular Physiology

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As a major cause of renal failure, transient renal ischemia and reperfusion induce both acute kidney injury and late fibrosis, which are the common pathological manifestations of end-stage renal disease. Curcumin is a biologically active polyphenolic compound found in turmeric. Increasing evidence has demonstrated that curcumin has a protective action against renal fibrosis, whereas mechanisms underlying the anti-fibrosis role of curcumin remain poorly defined. Here, we found that APPL1, an important intracellular binding partner for AdipoR, was involved in the pathogenesis of acute injury or fibrosis and was significantly upregulated by curcumin in a mouse model of ischemia reperfusion-induced late kidney fibrosis. Moreover, Akt signaling was the specific signaling pathway identified downstream of APPL1 in the pathogenesis of fibrosis. Our in vitro experiment demonstrated that curcumin alleviates ischemia reperfusion-induced late kidney fibrosis via the APPL1/Akt pathway. These data are helpful for understanding the anti-fibrosis mechanism of curcumin in the pathogenesis of AKI-induced late fibrosis.

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“…After a nephron dies, fibrosis occurs which can cause a chain reaction of additional nephron stress and death, which eventually decreases organ functionality [4][5][6] . This is the case in acute kidney injury (AKI), chronic kidney disease, and end stage renal disease as the kidney suffers an initial injury, advanced fibrosis, and total loss of function, respectively [7][8][9][10] . Finding treatments for these conditions is no easy task for regenerative medicine due to the intricate architecture of the kidney and its rich diversity of cell types [11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Insights into kidney stem cell development and regeneration using zebrafish

Drummond

Wingert

2016

WJSC

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Kidney disease is an escalating global health problem, for which the formulation of therapeutic approaches using stem cells has received increasing research attention. The complexity of kidney anatomy and function, which includes the diversity of renal cell types, poses formidable challenges in the identification of methods to generate replacement structures. Recent work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney, known as nephrons, following acute injury. Here, we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology, which may uncover important clues for regenerative medicine.

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Acute Kidney Injury and Chronic Kidney Disease: It’s a Two-Way Street

Cited by 22 publications

References 29 publications

Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury

Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury

Curcumin alleviates ischemia reperfusion‐induced late kidney fibrosis through the APPL1/Akt signaling pathway

Insights into kidney stem cell development and regeneration using zebrafish

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