Curcumin alleviates ischemia reperfusion‐induced late kidney fibrosis through the APPL1/Akt signaling pathway

Abstract

As a major cause of renal failure, transient renal ischemia and reperfusion induce both acute kidney injury and late fibrosis, which are the common pathological manifestations of end-stage renal disease. Curcumin is a biologically active polyphenolic compound found in turmeric. Increasing evidence has demonstrated that curcumin has a protective action against renal fibrosis, whereas mechanisms underlying the anti-fibrosis role of curcumin remain poorly defined. Here, we found that APPL1, an important intracellular binding partner for AdipoR, was involved in the pathogenesis of acute injury or fibrosis and was significantly upregulated by curcumin in a mouse model of ischemia reperfusion-induced late kidney fibrosis. Moreover, Akt signaling was the specific signaling pathway identified downstream of APPL1 in the pathogenesis of fibrosis. Our in vitro experiment demonstrated that curcumin alleviates ischemia reperfusion-induced late kidney fibrosis via the APPL1/Akt pathway. These data are helpful for understanding the anti-fibrosis mechanism of curcumin in the pathogenesis of AKI-induced late fibrosis.

Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells

“…Studies have suggested the protective effects of Cur against ischemia/reperfusion through the regulation of various pathways. For example, Chen et al found that Cur ameliorated ischemia/reperfusion-induced late kidney fibrosis by regulating the APPL1/Akt pathway [ 28 ]. Xu et al showed that Cur exerted neuroprotective effects against cerebral ischemia/reperfusion injury by regulating the MEK/ERK/CREB pathway [ 29 ].…”

Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19

“…Recently, some studies have identified potential molecular targets in the viral replication cycle to determine the potential role of curcumin in the fight against SARS-CoV-2 (4,84,(93)(94)(95)(96)(97)(98). White blood cells (WBCs) are the key players in human immune systems and specifically lymphocytes have been found to produce increased levels of immunoglobulins (IgG and IgM) when Nawab et al (77) investigated the effect of curcumin on the immune profiles of the blood.…”

Bisdemethoxycurcumin Induces Cell Apoptosis and Inhibits Human Brain Glioblastoma GBM 8401/Luc2 Cell Xenograft Tumor in Subcutaneous Nude Mice In Vivo

“…The curcuminoids in the turmeric acetone extract are crucial for the gastroprotective effect against ethanol-induced damage [ 14 ]. BDMC prevented kidney fibrosis by activating fibroblast apoptosis [ 15 ] and promoted apoptosis in human platelets via activation of ERK signaling pathway [ 16 ]. It induced cell apoptosis in liver cancer Hep 3B cells [ 17 ] and induced caspase-dependent and -independent apoptosis via Smad or Akt signaling pathways in osteosarcoma HOS cells [ 18 ].…”