Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19

Tripathy, Soubhagya; Verma, Deepak Kumar; Thakur, Mamta; Patel, Ami; Srivastav, Prem Prakash; Singh, Smita; Gupta, Alok; Chávez‐González, Mónica L.; Chakravorty, Nishant; Verma, Henu Kumar; Utama, Gemilang Lara

doi:10.3389/fnut.2021.747956

Cited by 37 publications

(16 citation statements)

References 182 publications

(244 reference statements)

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“…Several methods were found for extraction, isolation, and quantification. But the subcritical water extraction method and HPLC are the most effective method with a higher extraction yield ( 83 ).…”

Section: Phytochemicals Associated With Ginger Turmeric and Garlicmentioning

confidence: 99%

Functional bioactive compounds in ginger, turmeric, and garlic

et al. 2022

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Nutrition plays a very important role in the health promotion of individuals and brought about a global paradigm shift from pharmaceuticals to nutraceuticals. This is due to the high cost, non-availability, and side effects associated with the unregulated consumption of pharmaceuticals. Over the ages, nutraceuticals from food products were reported to contain bioactive compounds with great health and physiological benefits. This report reviews bioactive compounds in selected foods namely ginger (Zingiber officinale), turmeric (Curcuma longa), and garlic (Allium sativum) as potential natural therapeutics for ailments of cancer and heart-related diseases. Analytical profiles, functional activities, and characterization of these compounds were discussed with possible recommendations for the prospective treatment of diseases using these nutraceuticals.

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Section: Phytochemicals Associated With Ginger Turmeric and Garlicmentioning

confidence: 99%

Functional bioactive compounds in ginger, turmeric, and garlic

et al. 2022

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“…The traditional extraction method takes a long time and has a low extraction rate due to the degradation of CUR caused by high temperature. The commonly used modern method is ultrasonic-assisted extraction (UAE) [ 37 ]. Firstly, the turmeric rhizomes of the plants were cleaned, dried and were then ground into fine powder and passed through a sieve (20 mesh) [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Current Development and Future Application Prospects of Plants-Derived Polyphenol Bioactive Substance Curcumin as a Novel Feed Additive in Livestock and Poultry

Pan

Yan

Chen

et al. 2022

IJMS

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Curcumin (CUR) is a kind of natural orange-yellow phenolic compound mainly extracted from the stems and roots of turmeric plants and other species in the genus Curcuma, furthermore, it is also the most important active ingredient exerting pharmacological functions in turmeric. In recent years, CUR has been frequently reported and has attracted widespread attention from scholars all over the world due to its numerous biological functions and good application prospects, such as anti-inflammatory, anticancer, antioxidant and providing lipid-lowering effects, etc. In addition, adding a certain dose of CUR to livestock and poultry feed is important for animal growth and development, which plays a key role in animal metabolism, reproduction, immunity and clinical health care. This review aims to summarize, based on the published papers and our own observations, the physical and chemical properties and the biological functions of the plant-derived bioactive ingredient CUR, especially regarding the latest research progress in regulating intestinal health as well as its current development and future application prospects in livestock and poultry as a novel feed additive, so as to provide theoretical and practical references for the further study of the application of CUR as a novel feed additive and a potential new antibiotic substitute, thereby improving the research field of plant-derived bioactive ingredients and promoting the healthy development of livestock and poultry.

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“…Curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) are most responsible for the biological activity of turmeric [ 29 ]. The isolation of curcuminoids from turmeric rhizomes is achieved by applying conventional and modern extraction methods [ 30 ]. Soxhlet extraction [ 31 ] and maceration [ 32 ] are classic extraction methods.…”

Section: Isolation Of Curcumin From Turmeric Rhizome and Methods Of I...mentioning

confidence: 99%

Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.

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Curcumin Extraction, Isolation, Quantification and Its Application in Functional Foods: A Review With a Focus on Immune Enhancement Activities and COVID-19

Cited by 37 publications

References 182 publications

Functional bioactive compounds in ginger, turmeric, and garlic

Functional bioactive compounds in ginger, turmeric, and garlic

Current Development and Future Application Prospects of Plants-Derived Polyphenol Bioactive Substance Curcumin as a Novel Feed Additive in Livestock and Poultry

Curcumin: Biological Activities and Modern Pharmaceutical Forms

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