Acute inhalation of combustion smoke triggers neuroinflammation and persistent anxiety-like behavior in the mouse

Gorgun, Murat F.; Zhuo, Ming; Cortez, Ib Danelo; Dineley, Kelly T.; Englander, Ella W.

doi:10.1080/08958378.2018.1432728

Cited by 3 publications

(1 citation statement)

References 75 publications

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“…There is however little evidence for long-term effects of acute exposure. [ 204 ] reported consistent and increased anxiety-like behaviours and depressive features in mice exposed to smoke, in association with increased pro-inflammatory cytokines, decreased myelination and hippocampal astrogenesis and microgliosis (consistent with changes evident in experimental disease models and MDD) as a consequence of this exposure. Exposure to bushfires results in long-term mental health sequelae such as MDD, anxiety disorders, post-traumatic stress disorder (PTSD), somatisation and suicidality [ 205 , 206 , 207 ], but these sequelae are likely be related to trauma from the bushfire events themselves.…”

Section: Discussionmentioning

confidence: 59%

Environmental Stressors and the PINE Network: Can Physical Environmental Stressors Drive Long-Term Physical and Mental Health Risks?

Stapelberg

Branjerdporn

Adhikary

et al. 2022

IJERPH

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Both psychosocial and physical environmental stressors have been linked to chronic mental health and chronic medical conditions. The psycho-immune-neuroendocrine (PINE) network details metabolomic pathways which are responsive to varied stressors and link chronic medical conditions with mental disorders, such as major depressive disorder via a network of pathophysiological pathways. The primary objective of this review is to explore evidence of relationships between airborne particulate matter (PM, as a concrete example of a physical environmental stressor), the PINE network and chronic non-communicable diseases (NCDs), including mental health sequelae, with a view to supporting the assertion that physical environmental stressors (not only psychosocial stressors) disrupt the PINE network, leading to NCDs. Biological links have been established between PM exposure, key sub-networks of the PINE model and mental health sequelae, suggesting that in theory, long-term mental health impacts of PM exposure may exist, driven by the disruption of these biological networks. This disruption could trans-generationally influence health; however, long-term studies and information on chronic outcomes following acute exposure event are still lacking, limiting what is currently known beyond the acute exposure and all-cause mortality. More empirical evidence is needed, especially to link long-term mental health sequelae to PM exposure, arising from PINE pathophysiology. Relationships between physical and psychosocial stressors, and especially the concept of such stressors acting together to impact on PINE network function, leading to linked NCDs, evokes the concept of syndemics, and these are discussed in the context of the PINE network.

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