Effects of Danggui-Shaoyao-San on depression- and anxiety-like behaviors of rats induced by experimental tooth movement

Li, Hongshi; Li, Dongxia; Zhao, Guifeng; Gao, Yuan; Ke, Jie

doi:10.1007/s00056-021-00323-0

Cited by 3 publications

(6 citation statements)

References 36 publications

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“…Studies have confirmed that DSS is effective in treating depression. 7 , 8 MDSS is a further modified concoction based on DSS to treat depression, which nourishes the kidney, thus benefiting it; however, its specific clinical efficacy and detailed mechanism of action remain unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Danggui-Shaoyao-San (DSS) originated from the earliest Chinese monograph on the diagnosis and treatment of miscellaneous diseases, “Synopsis of Golden Chamber”, and is a traditional compound Chinese medicinal preparation composed mainly of Angelica and Paeoniae, which has been used since ancient times to nourish the heart and calm the mind, and modern studies have confirmed that this formula can significantly improve depression. 7 , 8 In recent years, famous Sichuan traditional Chinese medicine practitioners combined the clinical herbal characteristics and clinical medication experience to further improve the basis DSS of adding diuretic and kidney-nourishing herbs such as Rehmanniae, Poria and Amomum, etc., which nourish the liver and kidney, to form Modified Danggui-Shaoyao-San (MDSS). In the MDSS formula, Rehmanniae enters the kidneys and diuretic, while Angelica enters the liver, nourishes yin, nourishes blood, activates blood circulation, and invigorates blood circulation, which has become a famous local formula for the treatment of depression in CKD.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease

Xia¹,

Ai²,

Pang³

2022

DDDT

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Background Depression in Chronic Kidney Disease (CKD) seriously affects the prognosis of patients and Modified Danggui-Shaoyao-San (MDSS) is based on the traditional Chinese formula Danggui-Shaoyao-San (DSS) for the treatment of depression, which is further optimized. The aim of this study was to evaluate the clinical efficacy and safety of MDSS for the treatment of depression in CKD, and to explain the molecular mechanism of MDSS for the treatment of depression in CKD through pharmacology and molecular docking. Methods 62 patients were randomly divided into treatment group (treated with MDSS) and control group (treated with placebo) and assessed by Hamilton Depression Scale, and the primary outcome was to evaluate the efficacy of MDSS in improving depressive symptoms and the effect on liver and kidney function, electrolytes. In addition, we identified the core compounds and potential targets of MDSS through the TCMSP database. The GeneCards, OMIM and Disgenet databases were then used to identify molecular targets for CKD and depression. The target protein–protein interaction network was built using STRING database. Core targets were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Molecular docking was used to verify the relationship between core active compounds and proteins. Results Clinical results showed that CKD patients in the MDSS group had significantly improved depressive status with no significant adverse effects. By network pharmacology analysis, we found that the compound-target network mainly contained 47 compounds and 69 corresponding targets. 844 terms were analyzed by GO enrichment, and 254 signaling pathways in KEGG. Molecular docking showed that the top active compounds had high affinity with four targets. Conclusion We preliminarily investigated the efficacy of MDSS in the treatment of depression in CKD and revealed the characteristics of multiple compounds and multiple targets in MDSS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease

Xia¹,

Ai²,

Pang³

2022

DDDT

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“… Xu et al (2011) suggested that DSS exerted an antidepressant effect in the forced swimming test (FST) and chronic unpredictable mild stress (CUMS) models through influencing the central arginine vasopressin (AVP) system. Li et al (2022) demonstrated that DSS pretreatment can restore the impaired abilities of rats caused by ETM-induced depression- and anxiety-like behavior. Although the antidepressant effect of DSS has been discovered, the functional components and underlying mechanisms are still unclear at a systematic and comprehensive level.…”

Section: Introductionmentioning

confidence: 97%

“…DSS is one of the representative formulae to harmonize the liver and the spleen ( Xu et al, 2011 ). The clinical and pharmacological studies showed that DSS could relieve depressive symptoms in postmenopausal women ( Koike et al, 2004 ; Terauchi et al, 2014 ) and experimental animal ( Xu et al, 2011 ; Li et al, 2022 ). Terauchi et al (2014) demonstrated that DSS was effective in treating the symptoms of headaches and concomitant depression in women.…”

Section: Introductionmentioning

confidence: 99%

Mathematical algorithm–based identification of the functional components and mechanisms in depression treatment: An example of Danggui-Shaoyao-San

Gong

Wang

et al. 2022

Front. Cell Dev. Biol.

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Depression, a complex epidemiological mental disorder, affects around 350 million people worldwide. Despite the availability of antidepressants based on monoamine hypothesis of depression, most patients suffer side effects from these drugs, including psychomotor impairment and dependence liability. Traditional Chinese medicine (TCM) is receiving more and more attention due to the advantages of high therapeutic performance and few side effects in depression treatment. However, complex multicomponents and multi-targets in TCM hinder our ability to identify the functional components and molecular mechanisms of its efficacy. In this study, we designed a novel strategy to capture the functional components and mechanisms of TCM based on a mathematical algorithm. To establish proof of principle, the TCM formula Danggui-Shaoyao-San (DSS), which possesses remarkable antidepressant effect but its functional components and mechanisms are unclear, is used as an example. According to the network motif detection algorithm, key core function motifs (CIM) of DSS in treating depression were captured, followed by a functional analysis and verification. The results demonstrated that 198 pathways were enriched by the target genes of the CIM, and 179 coincided with the enriched pathways of pathogenic genes, accounting for 90.40% of the gene enrichment pathway of the C-T network. Then the functional components group (FCG) comprising 40 components was traced from CIM based on the target coverage accumulation algorithm, after which the pathways enriched by the target genes of FCG were selected to elucidate the potential mechanisms of DSS in treating depression. Finally, the pivotal components in FCG of DSS and the related pathways were selected for experimental validation in vitro and in vivo. Our results indicated good accuracy of the proposed mathematical algorithm in sifting the FCG from the TCM formula, which provided a methodological reference for discovering functional components and interpreting molecular mechanisms of the TCM formula in treating complex diseases.

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“…Actually, DSS used to be primarily used to treat gynecological diseases (Kotani et al, 1997;Lee et al, 2016). Subsequently, researchers have demonstrated that DSS can be applicable to ameliorate neurological disorders including Alzheimer's disease (Huang et al, 2020;Kim and Cho, 2020;Li et al, 2021). Fu et al (2022) recently reviewed that polysaccharide extracted from DSS play significant roles in the treatment of Alzheimer's disease through various mechanisms, such as antiinflammatory, anti-neuronal injury, and immune regulation.…”

Section: Introductionmentioning

confidence: 99%

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

Yang

Liu

et al. 2022

Front. Pharmacol.

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Danggui-Shaoyao-San (DSS) is one of traditional Chinese medicine, which recently was found to play a protective role in diabetic kidney disease (DKD). However, the pharmacological mechanisms of DSS remain obscure. This study would explore the molecular mechanisms and bioactive ingredients of DSS in the treatment of DKD through network pharmacology. The potential target genes of DKD were obtained through OMIM database, the DigSee database and the DisGeNET database. DSS-related targets were acquired from the BATMAN-TCM database and the STITCH database. The common targets of DSS and DKD were selected for analysis in the STRING database, and the results were imported into Cytoscape to construct a protein-protein interaction network. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analysis and Gene Ontology (GO) enrichment analysis were carried out to further explore the mechanisms of DSS in treating DKD. Molecular docking was conducted to identify the potential interactions between the compounds and the hub genes. Finally, 162 therapeutic targets of DKD and 550 target genes of DSS were obtained from our screening process. Among this, 28 common targets were considered potential therapeutic targets of DSS for treating DKD. Hub signaling pathways including HIF-1 signaling pathway, TNF signaling pathway, AMPK signaling pathway, mTOR signaling pathway, and PI3K-Akt signaling pathway may be involved in the treatment of DKD using DSS. Furthermore, TNF and PPARG, and poricoic acid C and stigmasterol were identified as hub genes and main active components in this network, respectively. In this study, DSS appears to treat DKD by multi-targets and multi-pathways such as inflammatory, oxidative stress, autophagy and fibrosis, which provided a novel perspective for further research of DSS for the treatment of DKD.

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Effects of Danggui-Shaoyao-San on depression- and anxiety-like behaviors of rats induced by experimental tooth movement

Cited by 3 publications

References 36 publications

Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease

Preliminary Exploration of Clinical Efficacy and Pharmacological Mechanism of Modified Danggui-Shaoyao San in the Treatment of Depression in Patients with Chronic Kidney Disease

Mathematical algorithm–based identification of the functional components and mechanisms in depression treatment: An example of Danggui-Shaoyao-San

Using network pharmacology to explore the mechanism of Danggui-Shaoyao-San in the treatment of diabetic kidney disease

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