Acute glomerulonephritis after human parvovirus B19 infection

Nakazawa, Tomoyuki; Tomosugi, Naohisa; Sakamoto, Kazuhide; Asaka, Mitsuhiro; Yuri, Takehisa; Ishikawa, Isao; Kitagawa, Shunsuke

doi:10.1016/s0272-6386(00)70070-9

Cited by 51 publications

(27 citation statements)

References 21 publications

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“…One investigation of children with Kawasaki disease found B19 viremia in 67% (233) (209), chronic autoimmune thrombocytopenia or neutropenia (291), and acute glomerulonephritis (82,227) have also been suggested as possible manifestations of B19 infection.…”

Section: B19 Infection In Pregnancy (I) Hydrops Fetalismentioning

confidence: 99%

Human Parvovirus B19

2002

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Parvovirus B19 (B19) was discovered in 1974 and is the only member of the family Parvoviridae known to be pathogenic in humans. Despite the inability to propagate the virus in cell cultures, much has been learned about the pathophysiology of this virus, including the identification of the cellular receptor (P antigen), and the control of the virus by the immune system. B19 is widespread, and manifestations of infection vary with the immunologic and hematologic status of the host. In healthy immunocompetent individuals B19 is the cause of erythema infectiosum and, particularly in adults, acute symmetric polyarthropathy. Due to the tropism of B19 to erythroid progenitor cells, infection in individuals with an underlying hemolytic disorder causes transient aplastic crisis. In the immunocompromised host persistent B19 infection is manifested as pure red cell aplasia and chronic anemia. Likewise, the immature immune response of the fetus may render it susceptible to infection, leading to fetal death in utero, hydrops fetalis, or development of congenital anemia. B19 has also been suggested as the causative agent in a variety of clinical syndromes, but given the common nature, causality is often difficult to infer. Diagnosis is primarily based on detection of specific antibodies by enzyme-linked immunosorbent assay or detection of viral DNA by dot blot hybridization or PCR. Treatment of persistent infection with immunoglobulin reduces the viral load and results in a marked resolution of anemia. Vaccine phase I trials show promising results

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Section: B19 Infection In Pregnancy (I) Hydrops Fetalismentioning

confidence: 99%

Human Parvovirus B19

2002

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“…Reported histologic features include endocapillary and/or mesangial proliferation often with subendothelial deposits together with granular deposition of C3 and IgG along capillary walls and mesangium, a pattern that is consistent with acute postinfectious glomerulonephritis. Viral genome has been detected in renal biopsies by PCR, and immunohistochemical analysis has demonstrated B19 antigen within glomeruli in some cases (48,51,52). Spontaneous recovery is common, but some have persistent renal dysfunction and/or proteinuria.…”

Section: Glomerular Diseases Associated With Parvovirusmentioning

confidence: 99%

Parvovirus B19 and the Kidney

Waldman¹,

Kopp²

2007

Clinical Journal of the American Society of Nephrology

113

105

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“…Several clinical presentations and histologic patterns have been described (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). As a clinical picture, female dominance, onset in the second or third decade of life, acute nephritic syndrome with hypocomplementemia often following a prodrome of fever, rash, and arthritis are most common.…”

Section: Discussionmentioning

confidence: 99%

Acute Glomerulonephritis in an Immunocompetent Elderly Woman after Contact with a Child who Had Been Diagnosed as Erythema Infectiosum

et al. 2012

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The prevalence of postinfectious glomerulonephritis has decreased in most developed countries. We report the case of a previously healthy, immunocompetent 65-year-old woman who developed acute glomerulonephritis associated with human parvovirus B19 infection. She was referred by her primary care physician for suspected congestive heart failure but she had an elevated creatinine level and an abnormal urinalysis. Renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. After biopsy, we learned that she had been in frequent contact with her grandson who had been diagnosed with erythema infectiosum. Her human parvovirus B19 serum IgM titer was elevated at 3.50, indicating current infection.

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Acute glomerulonephritis after human parvovirus B19 infection

Cited by 51 publications

References 21 publications

Human Parvovirus B19

Human Parvovirus B19

Parvovirus B19 and the Kidney

Acute Glomerulonephritis in an Immunocompetent Elderly Woman after Contact with a Child who Had Been Diagnosed as Erythema Infectiosum

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