Acute Glomerulonephritis in an Immunocompetent Elderly Woman after Contact with a Child who Had Been Diagnosed as Erythema Infectiosum

Kishi, Seiji; Yamada, Satoshi; Kishi, Fumi; Shibata, Eriko; Matsuura, Motokazu; Nagai, Kojiro; Mima, Akira; Abe, Hideharu; Doi, Toshio

doi:10.2169/internalmedicine.51.7919

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…None of the patients in our series developed serious disease, although the literature contains isolated reports of acute parvovirus B19 infection associated with acute fulminant hepatitis, 27 acute glomerulonephritis, 28 acute encephalitis and peripheral neuropathy, 29 myocarditis, and aplastic anemia in both immunocompetent and immunocompromised patients.…”

Section: Discussionmentioning

confidence: 78%

Acute Parvovirus B19 Infection in Adults: A Retrospective Study of 49 Cases

Bandera

Arenal

Vorlicka

et al. 2015

Actas Dermo-Sifiliográficas (English Edition)

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Objective: Our aim was to describe the epidemiologic, clinical, and laboratory characteristics of acute parvovirus B19 infection in adults. Material and methods: This study describes all cases of acute parvovirus B19 infection in patients older than 18 years of age who were treated at Hospital Universitario La Paz in Madrid, Spain, in 2012. Results: Forty-nine adults were treated for acute parvovirus B19 infection. Most were young women who were infected in the spring or early summer. In over half the cases skin lesions were key diagnostic signs. We saw the full range of types of rash of purplish exanthems that were fairly generalized; vasculitis was relatively common (in > 18%). Mild or moderate abnormalities in blood counts and indicators of liver dysfunction resolved spontaneously in all but 2 immunocompromised patients, who developed chronic anemia. Conclusions: This is the largest case series of acute parvovirus B19 infection published to date. This infection should be suspected on observing signs of purplish skin rashes, no matter the location or pattern of distribution, or vasculitis, especially if accompanied by fever and joint pain in young women in the spring. Measures to avoid infection should be recommended to individuals at risk. Estudio retrospectivo de 49 casos de infección aguda por parvovirus B19 en adultos ResumenObjetivo: El objeto de nuestro trabajo es describir las características epidemiológicas, clínicas y analíticas de la infección aguda por parvovirus B19 en adultos. Material y métodos: Presentamos un estudio descriptivo retrospectivo de todos los casos de infección aguda por parvovirus B19, en mayores de 18 años, durante el año 2012, en el Hospital Universitario La Paz, Madrid. Resultados: Cuarenta y nueve pacientes adultos con infección aguda por parvovirus B19. La mayoría ocurrieron en mujeres jóvenes en primavera y principios de verano. La lesión cutánea fue el signo fundamental para el diagnóstico en más del 50% de los casos. Se encontraron todo tipo de exantemas purpúricos más o menos generalizados, siendo relativamente frecuente la forma de vasculitis (> 18%). Las alteraciones en el hemograma y perfil hepático, leves o moderadas, se resolvieron espontáneamente, salvo en 2 pacientes inmunodeprimidos en quienes persistió una anemia crónica. Conclusiones: Es la serie más amplia de infección aguda por parvovirus B19 descrita, hasta la fecha, en la literatura. Ante exantemas purpúricos de cualquier distribución o lesiones de vasculitis, sobre todo si se acompañan de fiebre y artralgias y se presentan en mujeres jóvenes en primavera, debemos sospechar una infección aguda por parvovirus B19 y recomendar medidas para evitar el contagio a personas de riesgo.

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Section: Discussionmentioning

confidence: 78%

Acute Parvovirus B19 Infection in Adults: A Retrospective Study of 49 Cases

Bandera

Arenal

Vorlicka

et al. 2015

Actas Dermo-Sifiliográficas (English Edition)

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“…It remains uncertain whether this abnormality was caused by PVB19 or SLE, or if it had another origin such as stress cardiomyopathy. PVB19-induced nephropathy is multifactorial [15,16] but is often post-infectious glomerulonephritis. Pathological findings in our patient were consistent with SLE glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Presentation of Parvovirus B19 Infection and Systemic Lupus Erythematosus in a Patient: Description and Review of the Literature

Chabert

Kallel

2020

European Journal of Case Reports in Internal Medicine

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We present the case of a 25-year-old woman without medical history, presenting with acute respiratory failure needing mechanical ventilation. Aetiologic screening showed PVB19 primary infection and concomitant SLE flare-up. We discuss the causative interactions between PVB19 and SLE in the pathogenesis of the disease. Difficulty diagnosing inaugural SLE flare-up concomitant with PVB19 infection can lead to delayed diagnosis and treatment. Inversely, overtreating a SLE-mimicking PVB19 infection with immunosuppressive agents can be highly detrimental.

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“…Several different types of pathogens have been linked to PIGN, with bacteria such as streptococcus and staphylococcus being especially common instigators [ 1 ]. Various viruses such as human immunodeficiency virus, Epstein-Barr virus, hepatitis C virus, and human parvovirus B19 have also been implicated in PIGN [ 5 , 6 ]. PIGN may be especially common in tropical areas that are more advantageous for transmission [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

HBV-Associated Postinfectious Acute Glomerulonephritis: A Report of 10 Cases

Zhang

Peng

et al. 2016

PLoS ONE

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Postinfectious acute glomerulonephritis (PIGN) may occur after various bacterial and viral infections. Hepatitis B virus (HBV) infection is a cause of chronic glomerulonephritis. We report here 10 cases (ages 7–20 years-old) of chronic HBV carriers with acute glomerulonephritis, with positive glomerular staining of hepatitis B surface antigen, and detectable presence of HBV DNA in the glomeruli. This form of PIGN, HBV-PIGN, has not been previously identified. To further characterize clinical and pathological features of HBV- PIGN, we selected 10 cases of age-matched non-HBV PIGN for comparison. While both HBV associated PIGN and non-HBV PIGN similarly presented as proteinuria, hematuria, and hypertension, there was a trend of higher acute kidney injury and worsened prognosis in HBV-PIGN. 6 months after the onset, 4 patients with HBV associated PIGN did not show improvement from the disease, whereas all patients with non-HBV PIGN had complete or partial recovery. Pathologically, both HBV associated PIGN and non-HBV PIGN showed typical diffuse glomerular endocapillary proliferation, but HBV associated PIGN differed from classical PIGN with much fewer sub-epithelial glomerular “hump-shape” immune complex depositions. In conclusion, we have identified a novel association of HBV infection with acute glomerulonephritis.

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Acute Glomerulonephritis in an Immunocompetent Elderly Woman after Contact with a Child who Had Been Diagnosed as Erythema Infectiosum

Cited by 6 publications

References 33 publications

Acute Parvovirus B19 Infection in Adults: A Retrospective Study of 49 Cases

Acute Parvovirus B19 Infection in Adults: A Retrospective Study of 49 Cases

Simultaneous Presentation of Parvovirus B19 Infection and Systemic Lupus Erythematosus in a Patient: Description and Review of the Literature

HBV-Associated Postinfectious Acute Glomerulonephritis: A Report of 10 Cases

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