Simultaneous Presentation of Parvovirus B19 Infection and Systemic Lupus Erythematosus in a Patient: Description and Review of the Literature

Abstract

We present the case of a 25-year-old woman without medical history, presenting with acute respiratory failure needing mechanical ventilation. Aetiologic screening showed PVB19 primary infection and concomitant SLE flare-up. We discuss the causative interactions between PVB19 and SLE in the pathogenesis of the disease. Difficulty diagnosing inaugural SLE flare-up concomitant with PVB19 infection can lead to delayed diagnosis and treatment. Inversely, overtreating a SLE-mimicking PVB19 infection with immunosuppressive agents can be highly detrimental.

Autoimmune complications of COVID‐19

“…13 For instance, type 1 diabetes mellitus (T1DM) as one of the most prevalent autoimmune diseases has been suggested to be associated with coxsackievirus, 14 cytomegalovirus (CMV), 15 and enteroviruses. 16 Different types of viral infections such as hepatitis C virus (HCV), 17 CMV, 18 dengue virus, 19 and parvovirus B19 20,21 have been postulated to be associated with systemic lupus erythematosus (SLE) that represent a wide variety of autoimmune manifestations. Furthermore, multiple sclerosis (MS) has been found to be associated with Epstein-Barr virus (EBV), 22 measles virus, 23 Varicella-zoster virus, 24 and CMV 25,26 (Table 1).…”