Acute gastric ulcer with perforation in one of premature twins

Neonatal Gastric Perforation: Case Series and Literature Review

“…High gastric acidity in combination with local ischemia is also considered a significant etiologic factor in neonatal gastric perforation [8,21,22]. Animal studies show a marked reduction in the blood flow of the mucosa of the gastrointestinal tract during experimental asphyxia [11], supporting gastric tissue ischemia secondary to hypoxia as a reasonable explanation [10,12,18,21,[23][24][25]. However, some authors specifically denounce the theory of hypoxiainduced ischemia and subsequent gastric perforation, because necrotizing enterocolitis (NEC) has seldom been reported in neonates with gastric perforation [20].…”

Stomach

“…Brody (1940) illustrated the first case of the congenital absence of gastric musculature. Although the majority of the cases of gastric rupture were considered to be secondary to gastric ulceration (Smythe 1934;Bird et al 1941;Rosenberg and Heath 1946) or tube feeding (Dunham and Goldstein 1934;Kunz 1952;Potter 1952;Wagner et al 1952), Braunstein asserted that some gastric rupture cases with pyloric atresia and cases of perforation after tube feeding were the result of gastric musculature defects based on histological examinations (Braunstein 1954). The microscopic findings in the musculature defect parts revealed that the muscle of the wall ended abruptly in the surrounding tissue and no muscle was found in the defective section.…”