Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats

Fraga, Iliana; Fregoneze, J.B.; Carvalho, F.; Dantas, K.B.; Azevedo, C. S.; Pinho, Cristina Bacellar de; Silva, E. de Castro e

doi:10.1016/j.neuroscience.2005.03.010

Cited by 18 publications

(14 citation statements)

References 26 publications

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“…This increase was also seen in female rats treated acutely with fluoxetine (Torres et al, 1998). Most studies report no increase in the DRN, although Fraga et al (2005) did find an increase after administration of fluoxetine. When increases in the LC have been reported, it has been upon administration of the SSRI fluoxetine (Fraga et al, 2005;Slattery et al, 2005;Sumner et al, 2004) but, with one exception (Beck, 1995), not with other types of antidepressants.…”

Section: Discussionmentioning

confidence: 74%

“…Essentially all studies were conducted after acute (30 min-2 h) administration of antidepressants. A reasonably consistent observation is that administration of pharmacologically diverse antidepressants (SSRIs, selective NRIs, MAOIs, mirtazapine) increase c-fos or c-Fos in the central nucleus of the amygdala (CeA) and BNST (Beck, 1995;Duncan et al, 1996;Fraga et al, 2005;Miyata et al, 2005;Morelli et al, 1999;Slattery et al, 2005;Sumner et al, 2004;Thomsen and Helboe, 2003). This increase was also seen in female rats treated acutely with fluoxetine (Torres et al, 1998).…”

Section: Discussionmentioning

confidence: 83%

“…Most studies report no increase in the DRN, although Fraga et al (2005) did find an increase after administration of fluoxetine. When increases in the LC have been reported, it has been upon administration of the SSRI fluoxetine (Fraga et al, 2005;Slattery et al, 2005;Sumner et al, 2004) but, with one exception (Beck, 1995), not with other types of antidepressants. In general, increases have not been reported in the hippocampus and many other regions of brain and effects in cortical areas have been quite inconsistent.…”

Section: Discussionmentioning

confidence: 97%

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Induction of c-Fos and ΔFosB Immunoreactivity in Rat Brain by Vagal Nerve Stimulation

Cunningham

Mifflin

Gould

et al. 2007

Neuropsychopharmacol

144

118

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Vagus nerve stimulation (VNS) is used as therapy for treatment-resistant depression or epilepsy. This study used immunohistochemistry for biomarkers of short-term (c-Fos) and long-term (DFosB) neuronal activation to map regions in brain that are activated by acute (2 h) or chronic (3 weeks) VNS in conscious Sprague-Dawley rats. Electrodes (Cyberonics Inc.) were implanted on the left vagus nerve and 1 week after surgery, stimulation began using parameters employed clinically (one burst of 20 Hz, 250 ms pulse width, 0.25 mA stimulation for 30 s every 5 min). Radio telemetry transmitters were used for monitoring blood pressure, heart rate, activity, and respiratory rate during VNS; neither acute nor chronic VNS significantly affected these parameters. Acute VNS significantly increased c-Fos staining in the nucleus of the solitary tract, paraventricular nucleus of the hypothalamus, parabrachial nucleus, ventral bed nucleus of the stria terminalis, and locus coeruleus but not in the cingulate cortex or dorsal raphe nucleus (DRN). Acute VNS did not affect DFosB staining in any region. Chronic VNS significantly increased DFosB and c-Fos staining bilaterally in each region affected by acute VNS as well as in the cingulate cortex and DRN. Using these stimulation parameters, VNS was tested for antidepressant-like activity using the forced swim test (FST). Both VNS and desipramine significantly decreased immobility in the FST; whereas desipramine decreased immobility by increasing climbing behavior, VNS did so by increasing swimming behavior. This study, then, identified potential sites in brain where VNS may produce its clinical effects.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 97%

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Induction of c-Fos and ΔFosB Immunoreactivity in Rat Brain by Vagal Nerve Stimulation

Cunningham

Mifflin

Gould

et al. 2007

Neuropsychopharmacol

144

118

View full text Add to dashboard Cite

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“…5 We focused the genetic analysis on the functional OPRM1 A118G variant in exon1, for which the G allele is associated with reduced mRNA and protein levels. 6 Here, we report new data on the interacting effects of CREB1 and OPRM1 in nicotine reward. As described previously, 5 60 smokers (30 homozygous for the wildtype OPRM1 A118G A/A and 30 with at least one OPRM1 G allele) participated in a within-subject, double-blind investigation of effects of the MOR antagonist naltrexone (NTX) vs placebo on the relative reinforcing value of nicotine.…”

Section: Mgmentioning

confidence: 86%

“…For the determination of brain c-Fos expression, tissue preparation and immunohistochemical procedures were performed as described previously. 6 The experimental protocols were conducted according to the regulations established by the National Institutes of Health (USA). One-way analysis of variance, followed by the post hoc Dunnett t-test, was used to test for group effects on the counts of c-Fos-positive neurons in each anatomical structure.…”

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confidence: 99%

c-Fos expression identifies brain areas activated in response to nortriptyline

et al. 2007

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Manganese-enhanced magnetic resonance imaging (MEMRI) without compromise of the blood–brain barrier detects hypothalamic neuronal activityin vivo

Kuo

Herlihy

et al. 2006

NMR Biomed.

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There is growing interest in the use of manganese-enhanced MRI (MEMRI) to detect neuronal activity and architecture in animal models. The MEMRI neuronal activity studies have been generally performed either by stereotactic brain injection or by systemic administration of Mn(2+) in conjunction with the disruption of the blood-brain barrier (BBB). These approaches, however, have limited the use of MEMRI because of the procedure-related morbidity/mortality or because brain activity measured by these methods can diverge from genuine physiological responses. In this study, the hypothesis that MEMRI, performed with systemic administration of Mn(2+) without compromising the BBB integrity, is able to detect hypothalamic function associated with feeding was tested. This procedure was tested on a simple physiological condition, fasting, and with this method temporal and regional differences in Mn(2+) enhancement could be detected. It is concluded that MEMRI can be used to study hypothalamic function in the murine brain without compromising the BBB. It was also shown that region-specific Mn(2+) enhancement in the mouse brain can be modulated by fasting. More importantly, this non-invasive in vivo imaging technique is able to demonstrate differences in brain activities, previously possible only by in vitro studies.

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Acute fluoxetine administration differentially affects brain C-Fos expression in fasted and refed rats

Cited by 18 publications

References 26 publications

Induction of c-Fos and ΔFosB Immunoreactivity in Rat Brain by Vagal Nerve Stimulation

Induction of c-Fos and ΔFosB Immunoreactivity in Rat Brain by Vagal Nerve Stimulation

c-Fos expression identifies brain areas activated in response to nortriptyline

Manganese-enhanced magnetic resonance imaging (MEMRI) without compromise of the blood–brain barrier detects hypothalamic neuronal activityin vivo

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