“…It has been shown that exposure to ZEN leads to the abnormal synthesis of neuronal factors and enzymes in the brain neurons, induces apoptosis of the neuronal cells, increases oxidative stress reactions, influences the development of the nervous system, may cause behavioral aberrations and affects glial cell functions [ 189 , 190 , 191 , 192 ]. In turn, in the GI system, ZEN (among others) disturbs intestinal homeostasis, changes intestinal microbiome, causes inflammatory cell proliferation and inflammation in the intestinal mucosal layer [ 11 , 193 , 194 , 195 ].…”