Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

Lo, Emily Kwun Kwan; Lee, Jetty Chung‐Yung; Turner, Paul C.; El‐Nezami, Hani

doi:10.1038/s41598-021-86788-w

Cited by 27 publications

(14 citation statements)

References 49 publications

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“…Automatic cell counters have been developed and are commercially available. The LUNA TM system (LOGOS BIOSYSTEMS) used in [4][5][6] requires 10 µL of cell solution. It is based on conventional imaging and image processing is used to count the imaged cells.…”

Section: Introductionmentioning

confidence: 99%

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White light spectroscopy for T-cell culture growth monitoring: towards a real-time and sampling free device for ATMPs production

Vaccari¹,

Wacogne²,

Koubevi³

et al. 2021

J Transl Sci

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Nowadays, Advanced Therapy Medicinal Products (ATMPs) are new generation of pharmaceuticals which offer novel and revolutionary answer to be given to patients at the end of their therapeutic options. However, because of their prohibitive cost, they can only be proposed to a reduced number of patients. One possibility to reduce ATMP' price is to automate their production as much as possible. Among the numerous possibilities, a real-time and closed loop monitoring of the T-cell growth during the expansion phase would be appreciated. In this short paper, we propose a simple white light spectroscopy method which can be easily implemented in such an autonomous device and able to monitor T-cell number evolution with a higher accuracy as compared to current cell counting methods.

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Section: Introductionmentioning

confidence: 99%

“…In this expression, represent the absorption spectrum expressed in percentage. It is now straightforward to deduce:(4) …”

mentioning

confidence: 99%

White light spectroscopy for T-cell culture growth monitoring: towards a real-time and sampling free device for ATMPs production

Vaccari¹,

Wacogne²,

Koubevi³

et al. 2021

J Transl Sci

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“…Recent studies have reported that in HT29 and SW480 colorectal cancer cell lines, ZEN (3 μM) treatment can promote G-protein-coupled ER 1 and activate its downstream parallel signaling pathways MAPK and Yap1/TAZ, thereby promoting cell proliferation. 122…”

Section: The Mechanism and Pathway Of Zen-induced Toxicity In Vivomentioning

confidence: 99%

Toxicity of zearalenone and its nutritional intervention by natural products

et al. 2022

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“…In addition to aflatoxin, many other toxins have been identified as having carcinogenic activity such as fumonisins, ochratoxins, trichothecenes, and zearalenone [ 136 , 137 ]. Kwan Lo et al recently showed that low-dose zearalenone stimulated colon cancer cells in vitro through a G-protein-coupled estrogenic receptor [ 138 ]. Furthermore, zearalenone causes decreased expression of tight junction proteins with subsequent gut barrier dysfunction as well as gut bacterial dysbiosis [ 139 ].…”

Section: Mycobiomementioning

confidence: 99%

Exploring the Inflammatory Pathogenesis of Colorectal Cancer

et al. 2021

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Colorectal cancer is one of the most commonly diagnosed cancers worldwide. Traditionally, mechanisms of colorectal cancer formation have focused on genetic alterations including chromosomal damage and microsatellite instability. In recent years, there has been a growing body of evidence supporting the role of inflammation in colorectal cancer formation. Multiple cytokines, immune cells such T cells and macrophages, and other immune mediators have been identified in pathways leading to the initiation, growth, and metastasis of colorectal cancer. Outside the previously explored mechanisms and pathways leading to colorectal cancer, initiatives have been shifted to further study the role of inflammation in pathogenesis. Inflammatory pathways have also been linked to some traditional risk factors of colorectal cancer such as obesity, smoking and diabetes, as well as more novel associations such as the gut microbiome, the gut mycobiome and exosomes. In this review, we will explore the roles of obesity and diet, smoking, diabetes, the microbiome, the mycobiome and exosomes in colorectal cancer, with a specific focus on the underlying inflammatory and metabolic pathways involved. We will also investigate how the study of colon cancer from an inflammatory background not only creates a more holistic and inclusive understanding of this disease, but also creates unique opportunities for prevention, early diagnosis and therapy.

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Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

Cited by 27 publications

References 49 publications

White light spectroscopy for T-cell culture growth monitoring: towards a real-time and sampling free device for ATMPs production

White light spectroscopy for T-cell culture growth monitoring: towards a real-time and sampling free device for ATMPs production

Toxicity of zearalenone and its nutritional intervention by natural products

Exploring the Inflammatory Pathogenesis of Colorectal Cancer

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