Acute exercise ameliorates craving and inhibitory deficits in methamphetamine: An ERP study

Wang, Dongshi; Zhou, Changle; Chang, Yu Kai

doi:10.1016/j.physbeh.2015.04.008

Cited by 86 publications

(93 citation statements)

References 61 publications

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“…The data in the current report appear to coincide with recent research showing that exercise reduced methamphetamine use (Rawson et al, 2015) as well as craving in methamphetamine users (Wang et al, 2015). In addition, exercise significantly increased striatal DA D2/D3 binding potential in methamphetamine users (Robertson et al, 2015), and these data imply that exercise training may ameliorate dopaminergic deficits.…”

Section: Discussionsupporting

confidence: 88%

“…In one key study, an 8-week exercise intervention was utilized and the data showed that lower severity users (≤18 days/month) exhibited reductions in methamphetamine use at three time-points after study completion (Rawson et al, 2015). In a separate study, stationary cycling was also shown to reduce craving and inhibitory deficits in methamphetamine users (Wang et al, 2015). Last, exercise training (3 times weekly for 8 weeks) significantly increased striatal dopamine (DA) D 2 /D 3 binding potential in methamphetamine users (Robertson et al, 2015), which is likely of considerable import given that long-term methamphetamine use has been previously shown to reduce striatal DA binding (Volkow et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Treadmill exercise improves fitness and reduces craving and use of cocaine in individuals with concurrent cocaine and tobacco-use disorder

Garza

Yoon

Thompson-Lake

et al. 2016

Psychiatry Research

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Exercise may be a useful treatment for substance use disorders. Participants (N=24) included treatment-seeking individuals with concurrent cocaine and tobacco-use disorder (cigarette smokers). Participants were randomized to either running or walking (30 min per session, 3 times per week) or sitting (control condition) for 4 consecutive weeks. Several metrics indicated significant differences among runners, walkers, and sitters during sessions, including mean distance covered and calories burned. In addition, remote physiological monitoring showed that the groups differed significantly according to mean maximum heart rate (HR), respiration, and locomotor activity. Across the 4-week study, exercise improved fitness measures including significantly decreasing resting HR. Though not statistically significant, exercise improved abstinence from cocaine and increased self-reports of no cocaine use in last 24h. In general, reductions in tobacco use and craving were not as robust. To our knowledge, this is the first study to evaluate the effects of a multi-week exercise program in individuals with concurrent cocaine and tobacco-use disorder. The data clearly show significant improvements in basic fitness measures and several indices reveal that exercise improved both self-report and biochemically verified reports of cocaine abstinence. Taken together, the data from this study provides preliminary evidence for the efficacy of exercise for improving fitness and reducing cocaine use.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Treadmill exercise improves fitness and reduces craving and use of cocaine in individuals with concurrent cocaine and tobacco-use disorder

Garza

Yoon

Thompson-Lake

et al. 2016

Psychiatry Research

View full text Add to dashboard Cite

show abstract

“…While physical exercise has shown efficacy in correcting emotional deficits in METH users, METH craving is also a tempting target. Notably, Wang et al expanded Wang et al observations and further showed that acute aerobic exercise (5 minutes warm‐up, a 20‐minute main exercise on a stationary cycle ergometer at 50 RPMs, and a 5‐minute cooldown) may provide benefits for METH‐associated cravings and inhibitory control (which is referred as the ability to control inadequate behavior), as revealed by behavioral and neuroelectric measures. Moderate‐intensity exercise (heart rate within 65%‐75% of the participant's estimated maximum value) may be associated with more positive effects when compared with estimated maximum value and may be associated with more positive effects when compared with light and vigorous intensity.…”

Section: Clinical Evidence For Physical Exercise On Meth Addictionmentioning

confidence: 86%

The neurobiological mechanisms of physical exercise in methamphetamine addiction

et al. 2017

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Methamphetamine (METH) is the primary drug within amphetamine-type stimulants which are the second most abused group of drugs worldwide. There is no pharmacological treatment addressed specifically to METH addiction, and behavioral therapy is shadowed by poor long-term recovery and relapse. Therefore, novel approaches to manage METH addiction are an urgent need. This review aims to describe the current state of physical exercise use on methamphetamine addiction management. The following searching terms in PubMed were used: ("physical exercise" OR "exercise") AND "methamphetamine." Relevant references from key publications and gray literature were also reviewed to identify additional citations for inclusion. Original investigation regarding physical exercise and methamphetamine addiction (clinical data) or neurobiological mechanisms of physical exercise in animal models of methamphetamine administration (preclinical data) was included. Overall, METH users demonstrated improvements, including better fitness and emotional measures, lower relapse rates, and sustained abstinence when compared to nonexercised individuals. The neurobiological mechanisms of physical exercise in METH users seem to reflect an interplay of several agents, including neurochemicals, oxidative stress, neurogenesis, gliogenesis, and blood-brain barrier as disclosed by preclinical data. Exercise-based interventions alone or as a conjoint therapy may be a useful tool for managing METH addiction.

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“…Similar effects of exercise have been reported in numerous recent studies conducted in men and women with other substance use disorders (18–20; for meta-analyses see 9,58). For example, acute aerobic exercise (cycling) decreased drug-craving in women and men undergoing residential treatment for methamphetamine use disorder (19), and chronic aerobic exercise (8-week treadmill interval training) decreased measures of depression in men and women undergoing residential treatment for an illicit substance use disorder (i.e., heroin, amphetamine, cannabis; 18). Recent studies have also shown that aerobic exercise during abstinence can offset deficits in inhibitory control (19–20) that have been linked to relapse (60).…”

Section: Overview Of Clinical Findingsmentioning

confidence: 99%

Exercise as a Sex-Specific Treatment for Substance Use Disorder

et al. 2017

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Purpose of Review Exercise is a promising treatment for substance use disorder that may reduce withdrawal symptoms and prevent relapse. In this review, we discuss recent evidence from clinical and preclinical studies for its efficacy, from a behavioral to a molecular level, in order to understand the exercise conditions that lead to beneficial effects. We also highlight the few recent findings of sex-specific differences. Recent Findings Clinical and preclinical findings show that exercise decreases withdrawal symptoms, including craving, in both males and females. Evidence from clinical studies support the efficacy of exercise to prevent relapse to smoking, although further research is needed to examine sex differences, establish long-term efficacy, and to determine if effects extend to other substance use disorders. Preclinical findings also support the potential utility of exercise to prevent relapse with evidence suggesting that its efficacy is enhanced in males, and mediated by blocking drug-induced adaptations that occur during early abstinence. Summary Sex differences and timing of exercise availability during abstinence should be considered in future studies examining exercise as an intervention for relapse. A better understanding of the neurobiological mechanisms underlying the efficacy of exercise to reduce withdrawal symptoms and prevent relapse is needed to guide its development as a sex-specific treatment.

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Acute exercise ameliorates craving and inhibitory deficits in methamphetamine: An ERP study

Cited by 86 publications

References 61 publications

Treadmill exercise improves fitness and reduces craving and use of cocaine in individuals with concurrent cocaine and tobacco-use disorder

Treadmill exercise improves fitness and reduces craving and use of cocaine in individuals with concurrent cocaine and tobacco-use disorder

The neurobiological mechanisms of physical exercise in methamphetamine addiction

Exercise as a Sex-Specific Treatment for Substance Use Disorder

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